Product image of Ivermectin Substipharm (Ivermectin) supplied by GNH India

Ivermectin Substipharm

Active Ingredient:
Ivermectin
Origin:
EU

Ivermectin Substipharm (Ivermectin)

Ivermectin, the active ingredient in Ivermectin Substipharm, is an anthelmintic presented as an oral formulation for oral use. It is employed to treat a range of parasitic worm infections and ectoparasitic conditions in humans. The drug targets specific parasites, helping to eliminate infection and reduce disease transmission.

GNH India supplies Ivermectin Substipharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures reliable access to quality‑assured medicines across multiple regions.

Manufacturer / TM Owner

Substipharm

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Indications & Clinical Uses

  • Ivermectin is an anthelmintic used to treat infections caused by various helminths and ectoparasites.
  • Onchocerciasis: reduces microfilarial load and prevents disease progression.
  • Strongyloidiasis: eradicates intestinal larvae and prevents hyperinfection.
  • Scabies: eliminates the Sarcoptes mite, relieving itching and skin lesions.
  • Lymphatic filariasis: lowers circulating filarial worms, aiding control programs.
  • Other helminth infections: provides broad‑spectrum activity against multiple nematodes.

How It Works

  • Ivermectin binds selectively to glutamate‑gated chloride channels in the membranes of susceptible parasites. This binding increases chloride ion influx, hyperpolarising the neuronal and muscular cells, which leads to paralysis, loss of attachment, and eventual death of the parasite.

Side Effects

Ivermectin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Dizziness
  • Diarrhea

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome or severe skin rash
  • Hepatic injury
  • Anaphylactic reaction

Precautions & Warnings

Use of Ivermectin requires careful consideration of patient‑specific factors.

  • Pregnancy: safety not established; avoid unless benefit outweighs risk.
  • Breastfeeding: unknown; consider potential exposure to infant.
  • Renal impairment: use with caution and monitor renal function.
  • Hepatic impairment: dose adjustment may be required; monitor liver enzymes.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Ivermectin can interact with several drug classes, necessitating monitoring.

Major Interactions (Avoid)

  • Co‑administration with strong CYP3A4 inducers (e.g., rifampicin) may reduce efficacy.
  • Concurrent use with P‑glycoprotein inhibitors (e.g., verapamil) can increase plasma levels.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect; monitor INR.
  • Macrolide antibiotics: potential increase in ivermectin exposure; observe for toxicity.
  • Anticonvulsants: may alter seizure threshold; assess clinical response.

Frequently Asked Questions

Ivermectin Substipharm is used to treat parasitic infections such as onchocerciasis, strongyloidiasis, scabies, lymphatic filariasis and other helminth infections. It works by targeting the parasites responsible for these diseases, helping to eliminate the infection and reduce associated symptoms.

Ivermectin binds to glutamate‑gated chloride channels in the nervous and muscular systems of parasites. This binding increases chloride ion flow, causing hyperpolarisation, paralysis, and ultimately death of the parasite, thereby interrupting its life cycle.

The dosage of Ivermectin Substipharm is determined by the prescribing clinician based on the specific indication, patient weight, age, and clinical condition. Only a qualified healthcare professional should set the appropriate dose and schedule.

Safety data for Ivermectin Substipharm in pregnancy and lactation are limited. It is generally advised to avoid use during pregnancy unless the potential benefit justifies the risk, and to consider possible exposure to a nursing infant before prescribing.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ivermectin offers a broad‑spectrum oral option for several helminth and ectoparasite infections, often with a convenient single‑dose regimen. Compared with alternatives such as albendazole or praziquantel, ivermectin may be preferred for onchocerciasis and scabies, while other agents may be chosen based on parasite susceptibility and regional resistance patterns.

Ivermectin Substipharm should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and excessive heat to maintain its stability and potency.

The medication is administered orally, typically as a tablet or capsule taken with water. The exact method of administration, including whether it should be taken with food, is determined by the prescribing clinician based on the indication and patient factors.

Serious adverse reactions, although rare, can include severe skin reactions such as Stevens‑Johnson syndrome, hepatic injury, and anaphylaxis. Patients should be monitored for any signs of these conditions and seek immediate medical attention if they occur.

Ivermectin Substipharm should be avoided in individuals with known hypersensitivity to ivermectin or any excipients in the formulation. Caution is also advised for patients with severe hepatic or renal impairment, and it is generally contraindicated during pregnancy unless clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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