Product image of Ivermectine Biogaran (Ivermectin) supplied by GNH India

Ivermectine Biogaran

Active Ingredient:
Ivermectin
Origin:
EU

Ivermectine Biogaran (Ivermectin)

Ivermectin, the active ingredient in Ivermectine Biogaran, is an anthelmintic presented as an oral formulation for oral use. It treats a range of parasitic infections in humans, including strongyloidiasis, onchocerciasis, scabies, lymphatic filariasis and cutaneous larva migrans, and is administered under medical supervision.

GNH India supplies Ivermectine Biogaran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory‑compliant shipments to global markets.

Manufacturer / TM Owner

Biogaran

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Indications & Clinical Uses

Ivermectine Biogaran (ivermectin) is used to treat parasitic diseases that affect the skin, lymphatic system and intestinal tract.

  • Strongyloidiasis: eradicates intestinal Strongyloides stercoralis infection, reducing gastrointestinal symptoms.
  • Onchocerciasis: eliminates Onchocerca volvulus microfilariae, helping control river blindness.
  • Scabies: kills Sarcoptes scabiei mites, relieving itching and skin lesions.
  • Lymphatic filariasis: reduces Wuchereria bancrofti adult worms, aiding in disease control.
  • Cutaneous larva migrans: destroys migrating hookworm larvae in the skin, accelerating lesion resolution.

How It Works

  • Ivermectin binds selectively to glutamate‑gated chloride channels that are present in many invertebrates but absent in mammals. This binding increases the permeability of the channel to chloride ions, causing hyperpolarization of neuronal and muscle cells in the parasite. The resulting paralysis prevents the parasite from feeding or migrating, leading to its death and clearance from the host.

Side Effects

Ivermectine Biogaran may cause adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Nausea: mild stomach upset.
  • Diarrhea: loose stools.
  • Dizziness: transient light‑headedness.
  • Pruritus: itching at the site of infection.
  • Headache: mild to moderate.
  • Fatigue: general tiredness.

Serious or Rare Side Effects

  • Encephalopathy: altered mental status or seizures.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • Hypotension: sudden drop in blood pressure.
  • Anaphylaxis: acute allergic reaction with respiratory distress.

Precautions & Warnings

Before prescribing Ivermectine Biogaran, clinicians should consider several safety measures.

  • Assess liver function: evaluate hepatic status as ivermectin is metabolized hepatically.
  • Review allergy history: avoid in patients with known hypersensitivity to ivermectin or excipients.
  • Monitor neurologic signs: watch for dizziness, ataxia or visual disturbances.
  • Use caution in high parasite load: large infestations may increase risk of severe reactions.
  • Consider pregnancy status: weigh benefits against potential risks when prescribing to pregnant women.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ivermectine Biogaran can interact with other medicines, affecting its safety or efficacy.

Major Interactions (Avoid)

  • P‑glycoprotein inhibitors (e.g., cyclosporine, verapamil): may raise ivermectin plasma concentrations.
  • CNS depressants (e.g., benzodiazepines, alcohol): increase risk of neurotoxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: may potentiate anticoagulant effect, requiring INR monitoring.
  • Antiretrovirals (e.g., ritonavir): can alter ivermectin metabolism.
  • Macrolide antibiotics (e.g., erythromycin): may affect drug levels.
  • Antifungals (e.g., ketoconazole): potential for increased exposure.

Frequently Asked Questions

Ivermectine Biogaran contains ivermectin, an antiparasitic agent indicated for the treatment of strongyloidiasis, onchocerciasis, scabies, lymphatic filariasis and cutaneous larva migrans. It is prescribed to eliminate the causative parasites and relieve associated clinical symptoms.

Ivermectin binds to glutamate‑gated chloride channels in invertebrate nerve and muscle cells, increasing chloride ion flow. This hyperpolarizes the cells, causing paralysis of the parasite, which then loses its ability to feed or migrate and is eventually cleared by the host’s immune system.

The dose of Ivermectine Biogaran is individualized by the prescribing clinician based on the specific indication, patient weight, severity of infection and local treatment guidelines. No fixed regimen is provided here; the prescriber sets the appropriate dosage.

Safety data for ivermectin in pregnancy are limited, and the drug should only be used when the potential benefit justifies any potential risk to the fetus. Breastfeeding mothers should consult their healthcare provider, as ivermectin may be excreted in breast milk.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative for many of the same indications is albendazole, which belongs to the benzimidazole class. Ivermectin generally offers a single‑dose regimen for several infections and has a distinct mechanism targeting chloride channels, whereas albendazole interferes with microtubule formation and often requires multiple doses.

Ivermectine Biogaran should be stored at ambient temperature, preferably below 25 °C, in its original packaging. The container should be kept away from moisture, direct sunlight and sources of heat to maintain product stability.

The medication is taken orally, usually with a glass of water. Depending on the indication, it may be given as a single dose or a short course as directed by the prescriber. Patients should follow the specific instructions provided by their healthcare professional.

Serious adverse events include encephalopathy or seizures, severe skin reactions such as Stevens‑Johnson syndrome, hepatotoxicity, sudden hypotension and anaphylactic reactions. Any signs of neurological disturbance, severe rash, jaundice or difficulty breathing should prompt immediate medical evaluation.

Patients with known hypersensitivity to ivermectin or any excipients in the formulation should avoid the product. Caution is advised in individuals with severe hepatic impairment, high parasite burdens, or those taking interacting medications listed under major interactions. Pregnant women should only use it when clearly indicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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