Product image of Ivermectine Cristers (Ivermectin) supplied by GNH India

Ivermectine Cristers

Active Ingredient:
Ivermectin
Origin:
EU

Ivermectine Cristers (Ivermectin)

Ivermectin, the active ingredient in Ivermectine Cristers, is an antiparasitic presented as an oral formulation for systemic use. It is prescribed to treat several helminthic and ectoparasitic infections in both adults and children, such as onchocerciasis, strongyloidiasis, scabies and lice infestations, under medical supervision.

GNH India supplies Ivermectine Cristers as a licensed, EU‑origin, GDP‑compliant product to hospitals, pharmacies and clinics worldwide, supporting international procurement and distribution.

Manufacturer / TM Owner

Cristers

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Indications & Clinical Uses

Ivermectine Cristers (ivermectin) acts on parasitic organisms, providing therapeutic benefit across a range of infections.

  • Onchocerciasis: reduces microfilarial load and helps prevent ocular and skin disease.
  • Strongyloidiasis: eradicates intestinal larvae and lowers risk of hyperinfection syndrome.
  • Scabies: eliminates Sarcoptes scabiei mites, relieving itching and skin lesions.
  • Lice infestations: kills head and body lice, clearing infestations and preventing re‑colonisation.

How It Works

  • Ivermectin binds selectively to glutamate‑gated chloride channels in the nerve and muscle cells of invertebrates. This binding increases chloride ion influx, causing hyperpolarization of the cell membrane, which leads to paralysis and death of the parasite while having minimal effect on mammalian cells.

Side Effects

Ivermectine Cristers may be associated with a range of adverse reactions. Patients should be monitored for any new symptoms during therapy.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness: transient light‑headedness.
  • Pruritus: skin itching without rash.
  • Headache: mild tension‑type headache.

Serious or Rare Side Effects

  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • Neurologic toxicity: seizures or altered mental status.
  • Anaphylaxis: acute allergic reaction with respiratory compromise.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Pregnancy: safety not established; use only if potential benefit justifies the risk.
  • Breastfeeding: unknown excretion in milk; weigh maternal benefit against infant risk.
  • Hepatic impairment: dose adjustment may be required; monitor liver function.
  • Concomitant CNS depressants: may enhance sedation; observe for increased drowsiness.
  • Store below 25°C: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Ivermectine Cristers can interact with other medicines; awareness of interaction severity helps guide monitoring.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise ivermectin plasma concentrations.
  • Co‑administration with other antiparasitics: increased risk of neurotoxicity.
  • Warfarin: potential enhancement of anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Mild CYP3A4 inducers (e.g., rifampicin): may reduce therapeutic levels.
  • P‑gp inhibitors (e.g., verapamil): modest increase in ivermectin exposure.
  • Other CNS depressants: may augment dizziness or somnolence.
  • Antihistamines: possible additive pruritus relief, monitor for excessive sedation.

Frequently Asked Questions

Ivermectine Cristers contains ivermectin, which is indicated for several parasitic infections, including onchocerciasis (river blindness), strongyloidiasis (intestinal threadworm infection), scabies caused by Sarcoptes scabiei, and infestations of head and body lice. The medication is prescribed by a qualified health professional based on the specific diagnosis.

Ivermectin binds to glutamate‑gated chloride channels that are present in the nerve and muscle cells of many invertebrates. This binding opens the channels, allowing an influx of chloride ions, which hyperpolarizes the cells, leading to paralysis and eventual death of the parasite while sparing human cells.

The exact dose of Ivermectine Cristers is determined by the prescribing clinician, taking into account the patient’s age, weight, the specific infection being treated, and any relevant medical conditions. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for ivermectin in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Health professionals will evaluate each case individually before prescribing.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Ivermectin is a broad‑spectrum antiparasitic that is often preferred for its single‑dose efficacy against several helminths and ectoparasites. Compared with older agents such as albendazole or permethrin, ivermectin may offer a more convenient dosing regimen and a distinct safety profile, though the choice of therapy depends on the specific infection and patient factors.

Ivermectine Cristers should be stored at temperatures below 25 °C, in the original packaging to protect it from moisture and direct sunlight. Keeping the product in a dry, cool place helps maintain its potency throughout the shelf life.

The medication is taken orally, usually as a tablet or capsule, with water. The prescriber will indicate whether it should be taken with food or on an empty stomach, and the exact timing relative to meals if relevant.

Serious adverse events, although rare, can include severe skin reactions such as Stevens‑Johnson syndrome, hepatotoxicity, neurologic toxicity (e.g., seizures or altered mental status), and anaphylactic reactions. Patients should seek immediate medical attention if they experience symptoms like rash, jaundice, severe dizziness, or difficulty breathing.

Ivermectine Cristers is contraindicated in individuals with known hypersensitivity to ivermectin or any of the product’s excipients. Caution is also advised for patients with severe liver disease, those taking strong CYP3A4 inhibitors, and pregnant or breastfeeding women unless the benefits clearly outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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