Product image of Ivermectine Zentiva (Ivermectin) supplied by GNH India

Ivermectine Zentiva

Active Ingredient:
Ivermectin
Origin:
EU

Ivermectine Zentiva (Ivermectin)

Ivermectin, the active ingredient in Ivermectine Zentiva, is an anthelmintic presented as a / for oral use. It treats parasitic infections such as onchocerciasis, strongyloidiasis, scabies, lice infestations and other helminth infections in appropriate patients.

GNH India supplies Ivermectine Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva France

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Indications & Clinical Uses

Ivermectine Zentiva is used to treat parasitic diseases that affect the skin, intestines and other tissues.

  • Onchocerciasis: reduces microfilarial load and helps prevent blindness.
  • Strongyloidiasis: eliminates intestinal strongyloides infection.
  • Scabies: eradicates Sarcoptes scabiei infestation and relieves itching.
  • Lice infestations: clears Pediculus humanus capitis or corporis.
  • Other helminth infections: treats various nematode infections as indicated.

How It Works

  • Ivermectin binds selectively to glutamate‑gated chloride channels in the nerve and muscle cells of invertebrates. This binding increases chloride ion permeability, causing hyperpolarization of the cell membrane, leading to paralysis and death of the parasite. The drug shows minimal affinity for mammalian receptors, providing a therapeutic window for human use.

Side Effects

Ivermectine Zentiva may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea or abdominal discomfort.
  • Diarrhea or loose stools.
  • Dizziness or light‑headedness.
  • Itching or mild skin rash.
  • Headache.

Serious or Rare Side Effects

  • Severe allergic reactions such as anaphylaxis.
  • Neurological events including seizures or altered consciousness.
  • Hepatotoxicity manifested by jaundice or elevated liver enzymes.

Precautions & Warnings

When prescribing Ivermectine Zentiva, consider the following safety measures.

  • Dose adjustment in hepatic impairment: consider reduced dose.
  • Avoid in patients with known hypersensitivity: discontinue if rash or swelling occurs.
  • Monitor for neurologic symptoms: report dizziness, seizures, or confusion.
  • Use caution in co‑infection with Loa loa: risk of severe adverse events.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Ivermectine Zentiva can interact with other medicines; awareness of major and moderate interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole): may increase ivermectin plasma levels.
  • Co‑administration with P‑glycoprotein inhibitors (e.g., verapamil): risk of toxicity.

Moderate Interactions (Monitor Closely)

  • Concurrent use with warfarin: monitor INR closely.
  • Combination with other antiparasitic agents: assess additive toxicity.
  • Use with CNS depressants: observe for enhanced sedation or respiratory depression.

Frequently Asked Questions

Ivermectine Zentiva contains ivermectin, an anthelmintic indicated for the treatment of onchocerciasis (river blindness), strongyloidiasis, scabies, lice infestations and other helminth infections. It is prescribed by a qualified health professional for patients who require parasite eradication.

Ivermectin works by binding to glutamate‑gated chloride channels in the nerve and muscle cells of parasites. This increases chloride ion flow, hyperpolarising the cells, which leads to paralysis and death of the parasite while having limited effect on human cells.

The exact dose of Ivermectine Zentiva is determined by the prescribing clinician based on the specific indication, patient weight, age and clinical condition. Standard dosing regimens vary, and the prescriber will provide individualized instructions.

Safety data for ivermectin in pregnancy and lactation are limited. The drug should only be used during pregnancy or while breastfeeding if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and after careful medical evaluation.

To order Ivermectine Zentiva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ivermectine Zentiva offers a broad spectrum of activity against several parasitic diseases with a single oral formulation, whereas many alternatives target only one condition or require multiple agents. Its mechanism of selective chloride channel binding provides efficacy with a generally favorable safety profile compared with some older antiparasitics.

Ivermectine Zentiva should be stored at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid storing in areas with high humidity or temperature fluctuations.

The medication is taken orally, usually with a glass of water. Depending on the indication, it may be administered as a single dose or a short course as directed by the prescriber. Patients should follow the exact instructions provided on the prescription label.

Serious adverse events, although rare, include severe allergic reactions such as anaphylaxis, neurological complications like seizures or altered consciousness, and significant liver injury. Any sudden or severe symptoms should prompt immediate medical attention.

Individuals with known hypersensitivity to ivermectin or any component of the formulation should avoid the product. Patients with high microfilarial loads of Loa loa infection are at increased risk of severe reactions and should not receive ivermectin without specialist assessment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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