Product image of Iverscab (Ivermectin) supplied by GNH India

Iverscab

Active Ingredient:
Ivermectin
Origin:
EU

Iverscab (Ivermectin)

Ivermectin, the active ingredient in Iverscab, is an antiparasitic (anthelmintic) presented as a tablet for oral use. It treats a range of helminthic and ectoparasitic infections in both adults and children.

GNH India supplies Iverscab as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Substipharm

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Indications & Clinical Uses

Ivermectin is used to treat parasitic diseases by targeting the organisms responsible for infection.

  • Strongyloidiasis: eliminates intestinal Strongyloides stercoralis, reducing chronic infection and preventing hyperinfection.
  • Onchocerciasis: kills Onchocerca volvulus microfilariae, helping control river blindness.
  • Scabies: eradicates Sarcoptes scabiei mites, relieving skin infestation.
  • Lymphatic filariasis: reduces Wuchereria bancrofti adult worms, aiding in disease control.
  • Other parasitic infections: provides broad‑spectrum activity against various nematodes and ectoparasites.

How It Works

  • Ivermectin binds selectively to glutamate‑gated chloride channels in invertebrate nerve and muscle cells. This binding increases chloride ion influx, hyperpolarising the cell membrane, leading to paralysis and death of the parasite. Mammalian cells lack these channels, which accounts for the drug’s selective toxicity. The drug is poorly absorbed systemically, concentrating in the gut where many parasites reside, and it is metabolised primarily by hepatic enzymes.

Side Effects

Ivermectin may cause adverse reactions ranging from mild to severe.

Common Side Effects

  • Nausea: mild stomach upset often transient.
  • Dizziness: occasional light‑headedness.
  • Diarrhea: loose stools during treatment.
  • Headache: mild to moderate pain.

Serious or Rare Side Effects

  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatotoxicity: elevated liver enzymes or hepatitis.
  • Neurologic effects: seizures, ataxia or altered consciousness.

Precautions & Warnings

When prescribing Iverscab, clinicians should consider the following precautions.

  • Liver function: assess hepatic status before initiating therapy.
  • Hypersensitivity: avoid in patients with known allergy to ivermectin or excipients.
  • Concomitant CNS depressants: use with caution as additive neuro‑depressive effects may occur.
  • Pregnancy and lactation: evaluate risk‑benefit; limited data available.
  • Drug interactions: review concurrent medications for potential interactions.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ivermectin can interact with other medicines; notable interactions include:

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase ivermectin plasma levels.
  • P‑glycoprotein inhibitors (e.g., verapamil, quinidine): can raise systemic exposure.
  • Co‑administration with other neurotoxic anthelmintics: risk of additive neurotoxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible increase in INR, monitor coagulation.
  • Statins (e.g., simvastatin): may raise risk of myopathy.
  • Macrolide antibiotics (e.g., erythromycin): moderate CYP3A4 inhibition, observe for enhanced effects.

Frequently Asked Questions

Iverscab, containing ivermectin, is indicated for the treatment of several parasitic infections including strongyloidiasis, onchocerciasis (river blindness), scabies, lymphatic filariasis, and a range of other nematode or ectoparasite infections. It is used in both adult and pediatric patients as directed by a qualified health professional.

Ivermectin works by binding to glutamate‑gated chloride channels that are present in the nerve and muscle cells of parasites. This binding opens the channels, allowing an influx of chloride ions, which hyperpolarises the cells, leading to paralysis and death of the parasite while sparing human cells that lack these channels.

The dose of Iverscab is determined by the prescribing clinician based on the specific infection being treated, the patient’s age, weight, renal and hepatic function, and any relevant clinical guidelines. No standard dose is provided here; the prescriber will calculate the appropriate regimen for each individual case.

Safety data for ivermectin in pregnancy and lactation are limited. The prescriber should weigh the potential benefits against possible risks before prescribing Iverscab to pregnant or nursing women. If treatment is essential, it may be used under close medical supervision, but alternative therapies are considered when possible.

To order Iverscab, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details and any necessary import documentation.

Iverscab (ivermectin) offers a broad‑spectrum oral option that is effective against many nematodes and ectoparasites, often with a convenient single‑dose regimen. Compared with other classes such as benzimidazoles or praziquantel, ivermectin has a distinct mechanism of action and may be preferred for infections like onchocerciasis and scabies, while other agents may be chosen for different parasite species or resistance patterns.

Iverscab should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging to protect them from moisture, light and excessive heat. Do not store in a refrigerator or freezer unless specifically instructed by the manufacturer.

Iverscab is taken orally, usually as a whole tablet with water. The exact timing (e.g., with or without food) and frequency depend on the indication and the prescriber’s instructions. Patients should follow the dosing schedule provided by their healthcare professional and complete the full course of therapy.

Serious adverse events, although rare, include severe skin reactions such as Stevens‑Johnson syndrome, hepatotoxicity manifested by elevated liver enzymes or hepatitis, and neurologic effects like seizures, ataxia or altered consciousness. Patients should seek immediate medical attention if they experience rash, jaundice, severe abdominal pain, visual changes, or neurological symptoms.

Iverscab should be avoided in individuals with a known hypersensitivity to ivermectin or any of the tablet’s excipients. Caution is also advised for patients with severe hepatic impairment, those taking strong CYP3A4 or P‑glycoprotein inhibitors, and individuals with a history of neurologic disorders that could be exacerbated by the drug.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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