Product image of Ivesk (Ivermectin) supplied by GNH India

Ivesk

Active Ingredient:
Ivermectin
Origin:
EU

Ivesk (Ivermectin)

Ivermectin, the active ingredient in Ivesk, is an antiparasitic (macrocyclic lactone) presented as an oral tablet for oral use. It treats a range of parasitic infections, including strongyloidiasis, onchocerciasis, scabies, pediculosis and other intestinal nematode diseases, and is prescribed for patients requiring systemic therapy.

GNH India supplies Ivesk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to European Union quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Giuliani Spa

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Indications & Clinical Uses

Ivermectin is an antiparasitic agent used to treat infections caused by nematodes and ectoparasites.

  • Strongyloidiasis: eradicates Strongyloides stercoralis from the intestine, clearing chronic infection.
  • Onchocerciasis (river blindness): kills microfilariae, reducing ocular and skin manifestations.
  • Scabies: eliminates Sarcoptes scabiei mites, relieving itching and skin lesions.
  • Pediculosis (lice infestation): destroys head and body lice, preventing re‑infestation.
  • Other intestinal nematode infections: removes various soil‑transmitted helminths, improving gastrointestinal health.

How It Works

  • Ivermectin binds selectively to glutamate‑gated chloride channels found in invertebrate nerve and muscle cells. This binding increases the permeability of the cell membrane to chloride ions, leading to hyperpolarization, paralysis, and eventual death of the parasite. Mammalian cells lack these channels, which accounts for the drug’s selective toxicity toward parasites.

Side Effects

Ivermectin may cause a range of adverse reactions, which are classified as common or serious.

Common Side Effects

  • Nausea
  • Diarrhea
  • Abdominal pain
  • Dizziness
  • Headache
  • Pruritus

Serious or Rare Side Effects

  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Hepatotoxicity manifested by elevated liver enzymes
  • Neurologic events including seizures, confusion or ataxia
  • Hypotension and visual disturbances

Precautions & Warnings

When prescribing Ivesk, clinicians should observe the following precautions.

  • Pregnancy: safety not established; avoid unless benefits outweigh potential risks.
  • Breastfeeding: use with caution; monitor infant for possible adverse effects.
  • Renal or hepatic impairment: consider dose adjustment and monitor function.
  • Concomitant medications: review for potential interactions before initiating therapy.
  • Pediatric use: limit to children weighing ≥15 kg; safety in younger children is not confirmed.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Ivermectin can interact with several medicines; awareness of major and moderate interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Warfarin: may potentiate anticoagulant effect, increasing bleeding risk.
  • Benzodiazepines: enhanced central nervous system depression.
  • Macrolide antibiotics (e.g., erythromycin): can raise ivermectin plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Protease inhibitors (e.g., ritonavir): may alter ivermectin metabolism.
  • St. John’s Wort: may reduce ivermectin efficacy by inducing metabolism.
  • P‑glycoprotein inhibitors (e.g., verapamil): may increase systemic exposure.

Frequently Asked Questions

Ivesk contains ivermectin and is prescribed for several parasitic diseases, including strongyloidiasis, onchocerciasis (river blindness), scabies, pediculosis (lice infestation), and a variety of other intestinal nematode infections that affect the gastrointestinal tract.

Ivermectin binds to glutamate‑gated chloride channels that are present on the nerve and muscle cells of invertebrates. This binding opens the channels, allowing an influx of chloride ions, which hyperpolarises the cells, causing paralysis and death of the parasite while sparing human cells.

The dose of Ivesk is determined by the prescribing clinician based on the specific indication, the patient’s body weight, age, renal and hepatic function, and any relevant comorbidities. The prescriber follows approved dosing guidelines for each condition.

Safety of ivermectin in pregnancy has not been established, and it is generally avoided unless the potential benefit justifies the risk. During breastfeeding, caution is advised; the drug may be excreted in milk, so the infant should be monitored for adverse effects.

To order Ivesk, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ivermectin and albendazole belong to different antiparasitic classes; ivermectin is a macrocyclic lactone effective against many nematodes and ectoparasites, while albendazole is a benzimidazole primarily used for tapeworms and some roundworms. Choice of therapy depends on the parasite species, resistance patterns and clinical guidelines.

Ivesk should be stored at ambient temperature below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat and direct light, and ensure the container is tightly closed to maintain product stability.

Ivesk is taken orally as a tablet with water. The exact timing (with or without food) and the number of doses depend on the indication and the prescriber’s instructions. Patients should follow the dosing schedule provided by their healthcare professional.

Serious risks, although rare, include severe skin reactions such as Stevens‑Johnson syndrome, hepatotoxicity with elevated liver enzymes, neurologic events like seizures or confusion, and significant hypotension or visual disturbances. Patients should seek immediate medical attention if any of these symptoms occur.

Ivesk should be avoided in patients with known hypersensitivity to ivermectin or any excipients, in children weighing less than 15 kg, and in individuals where the risk of adverse effects outweighs the therapeutic benefit, such as certain pregnant women or patients with severe hepatic impairment without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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