Product image of Ivhebex (Human Hepatitis B Immunoglobulin) supplied by GNH India

Ivhebex

Active Ingredient:
Human Hepatitis B Immunoglobulin
Origin:
EU

Ivhebex (Human Hepatitis B Immunoglobulin)

Human Hepatitis B Immunoglobulin, the active ingredient in Ivhebex, is an immunoglobulin presented as a solution for injection for intravenous use. It provides passive immunity for hepatitis B exposure and is used in post‑exposure prophylaxis, prevention of mother‑to‑child transmission, and high‑risk prophylaxis.

GNH India supplies Ivhebex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lfb Biomedicaments

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Indications & Clinical Uses

Ivhebex, a human hepatitis B immunoglobulin, acts within the antiviral immune pathway to prevent hepatitis B virus infection.

  • Post‑exposure prophylaxis: provides immediate passive immunity to individuals exposed to hepatitis B virus.
  • Mother‑to‑child transmission prevention: reduces risk of vertical transmission when administered to pregnant women or newborns.
  • High‑risk prophylaxis: protects healthcare workers or others with significant exposure risk from acquiring hepatitis B infection.

How It Works

  • Human Hepatitis B Immunoglobulin supplies anti‑HBs antibodies that bind to hepatitis B surface antigens, neutralizing the virus and blocking its entry into hepatocytes. This passive immunization supplies immediate protection while the host’s own adaptive immune response develops, thereby preventing infection and disease progression.

Side Effects

Adverse reactions may occur following intravenous administration of Ivhebex.

Common Side Effects

  • Fever
  • Chills
  • Headache
  • Nausea
  • Injection‑site erythema or discomfort
  • Fatigue

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction
  • Hemolysis
  • Acute renal dysfunction
  • Thrombosis or embolic events
  • Aseptic meningitis
  • Severe hypotension

Precautions & Warnings

Ivhebex should be used with careful clinical assessment and monitoring.

  • Assess hepatitis B status: confirm need for passive immunization before administration.
  • Monitor for allergic reactions: observe patients for signs of anaphylaxis during and after infusion.
  • Evaluate renal function: consider dose adjustment or close monitoring in patients with renal impairment.
  • Avoid in individuals with known IgA deficiency: risk of severe hypersensitivity.
  • Use with caution in pregnancy: safety category unknown, weigh benefits against potential risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ivhebex may interact with other biologic products and therapies.

Major Interactions (Avoid)

  • Concurrent IgA‑containing blood products: increased risk of severe allergic reactions.
  • Live vaccines: potential interference with vaccine efficacy.
  • Immunosuppressive agents: may diminish passive immunity effect.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: possible alteration of clotting parameters.
  • Corticosteroids: may affect immune response to the immunoglobulin.
  • Non‑live vaccines: monitor serologic response after administration.

Frequently Asked Questions

Ivhebex is a human hepatitis B immunoglobulin indicated for post‑exposure prophylaxis of hepatitis B infection, prevention of mother‑to‑child transmission, and prophylaxis in individuals at high risk of acquiring hepatitis B.

The immunoglobulin provides passive immunity by delivering anti‑HBs antibodies that bind to hepatitis B surface antigens, neutralizing the virus and preventing it from infecting liver cells while the patient’s own immune system develops a response.

The prescribed dose of Ivhebex is determined by the treating physician based on the patient’s weight, exposure risk, and clinical situation. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety of Ivhebex in pregnancy and lactation has not been fully established. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and decisions should be made by the healthcare provider.

To order Ivhebex, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Ivhebex provides immediate passive immunity through anti‑HBs antibodies, whereas hepatitis B vaccines stimulate active immunity over weeks. Compared with other immunoglobulin products, Ivhebex offers a standardized EU‑sourced preparation with consistent antibody titres.

Ivhebex must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Before use, allow the solution to reach room temperature if required, and inspect for particulate matter.

Ivhebex is administered intravenously as a solution for injection. The infusion rate and volume are determined by the prescriber, and patients should be monitored for adverse reactions during and after the infusion.

The most serious risks include severe allergic reactions such as anaphylaxis, hemolysis, acute renal dysfunction, and thrombotic events. Immediate medical attention is required if any of these symptoms occur.

Ivhebex should not be given to individuals with a known severe IgA deficiency or a documented hypersensitivity to human immunoglobulins. It is also contraindicated in patients who have experienced prior anaphylactic reactions to similar products.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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