Product image of Ivlan (Ivabradine Hydrochloride) supplied by GNH India

Ivlan

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivlan (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Ivlan, is a If channel inhibitor presented as an oral tablet for oral use. It lowers heart rate and is used in the management of chronic stable angina pectoris and heart failure with reduced ejection fraction in adult patients.

GNH India supplies Ivlan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pygen, Lda

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Indications & Clinical Uses

Ivlan (ivabradine) is indicated for conditions where reduction of heart rate improves clinical outcomes.

  • Chronic stable angina pectoris: reduces the frequency of angina attacks by lowering heart rate without affecting contractility.
  • Heart failure with reduced ejection fraction: decreases hospitalization risk by improving ventricular filling time through heart‑rate reduction.
  • Symptomatic angina despite optimal therapy: provides additional heart‑rate control to improve exercise tolerance.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sino‑atrial node, which slows spontaneous depolarisation. By reducing the slope of phase 4 depolarisation, it lowers the heart rate while preserving myocardial contractility and blood pressure, thereby improving cardiac efficiency in angina and heart‑failure patients.

Side Effects

Ivabradine may be associated with several adverse reactions, which are categorised by frequency.

Common Side Effects

  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Bradycardia: symptomatic slow heart rate.
  • Headache.
  • Dizziness.

Serious or Rare Side Effects

  • Atrial fibrillation.
  • Severe bradycardia requiring intervention.
  • Allergic reactions (rash, angioedema).

Precautions & Warnings

When prescribing Ivlan, clinicians should consider the following precautions.

  • Initiate therapy only after confirming the indicated cardiovascular condition.
  • Monitor heart rate regularly; adjust dose if resting heart rate falls below 50 bpm.
  • Avoid use in patients with severe hepatic impairment.
  • Exercise caution in patients with pre‑existing atrial fibrillation.
  • Review concomitant medications that affect cardiac conduction.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture.

Avoid Interactions

Ivlan can interact with several medicines; interactions are grouped by clinical significance.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase ivabradine exposure.
  • Co‑administration with other bradycardic agents (beta‑blockers, digoxin): risk of excessive heart‑rate reduction.
  • QT‑prolonging drugs combined with ivabradine may raise arrhythmia risk.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., diltiazem, verapamil): may require dose adjustment.
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce ivabradine effectiveness.
  • Antidepressants affecting cardiac conduction (e.g., amitriptyline): monitor heart rate.

Frequently Asked Questions

Ivlan contains ivabradine and is used to lower heart rate in adults with chronic stable angina pectoris and in patients with heart failure with reduced ejection fraction. By reducing heart rate, it helps relieve angina symptoms and can improve outcomes in heart‑failure patients.

Ivabradine selectively blocks the funny (If) current in the sino‑atrial node, which slows the spontaneous depolarisation that sets the heart’s rhythm. This results in a lower resting heart rate while preserving contractile strength and blood pressure, supporting better cardiac efficiency.

The dose of Ivlan is individualized by the prescribing clinician based on the patient’s condition, heart‑rate response, and tolerability. Healthcare providers follow regional guidelines and may start with a low dose, titrating as needed while monitoring heart rate and symptoms.

Safety data for ivabradine during pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Ivlan, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ivabradine differs from beta‑blockers, the traditional heart‑rate‑lowering class, because it reduces heart rate without affecting myocardial contractility or blood pressure. It is often considered when beta‑blockers are contraindicated, not tolerated, or when additional heart‑rate control is needed.

Ivlan tablets should be stored at ambient temperature below 25 °C, in the original packaging, and protected from moisture and direct sunlight. Keep the product out of reach of children and do not use after the expiry date.

Ivlan is taken orally as a tablet. The tablet should be swallowed whole with a glass of water and can be taken with or without food. Patients should follow the dosing schedule prescribed by their healthcare provider.

Serious risks include new‑onset atrial fibrillation, severe bradycardia that may cause dizziness or syncope, and allergic reactions such as rash or angioedema. Patients should seek immediate medical attention if they experience palpitations, fainting, or severe visual changes.

Ivlan is contraindicated in patients with severe hepatic impairment, sick sinus syndrome, second‑ or third‑degree atrioventricular block, or those with uncontrolled atrial fibrillation. It should also be avoided in individuals taking strong CYP3A4 inhibitors without appropriate dose adjustment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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