Product image of Iwabradyna Synthon (Ivabradine Hydrochloride) supplied by GNH India

Iwabradyna Synthon

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Iwabradyna Synthon (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Iwabradyna Synthon, is an If channel inhibitor presented as an oral tablet for oral use. By selectively inhibiting the funny (If) current in the sinoatrial node, it lowers heart rate and is indicated for chronic stable angina and heart failure with reduced ejection fraction in adult patients.

GNH India supplies Iwabradyna Synthon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance through rigorous testing.

Manufacturer / TM Owner

Synthon Bv

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Indications & Clinical Uses

Ivabradine acts on cardiac pacemaker activity and is used in conditions where heart rate reduction improves outcomes.

  • Chronic stable angina: reduces the frequency of angina attacks and improves exercise tolerance.
  • Heart failure with reduced ejection fraction: lowers heart rate, decreasing myocardial oxygen demand and reducing hospitalization risk.
  • Ischemic heart disease: helps control heart rate, alleviating symptoms related to myocardial ischemia.

How It Works

  • Ivabradine selectively blocks the funny (If) sodium‑potassium current in the sinoatrial node. By inhibiting this pacemaker current, the drug slows spontaneous depolarization, leading to a reduction in heart rate without affecting myocardial contractility or blood pressure. The heart‑rate lowering effect decreases myocardial oxygen consumption, which underlies its therapeutic benefit in angina and heart‑failure patients.

Side Effects

Ivabradine may be associated with a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Bradycardia: abnormally low heart rate.
  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Headache.
  • Dizziness.
  • Fatigue.
  • Nausea.

Serious or Rare Side Effects

  • Severe bradycardia requiring medical intervention.
  • Symptomatic hypotension.
  • Atrial fibrillation.
  • Visual loss or persistent visual disturbances.
  • Cardiac arrest.
  • Severe allergic reactions (anaphylaxis).

Precautions & Warnings

When prescribing Ivabradine, several safety considerations should be observed.

  • Heart rate monitoring: check resting heart rate before initiation and periodically thereafter.
  • Contraindication in severe hepatic impairment: avoid use or adjust dose.
  • Caution in patients with sick sinus syndrome or atrioventricular block: assess conduction status.
  • Use with caution when combined with other bradycardic agents such as beta‑blockers or digoxin.
  • Dose adjustment in renal impairment: evaluate renal function and modify dose if needed.
  • Store at room temperature: keep in the original package, protect from moisture and light.

Avoid Interactions

Ivabradine can interact with other medicines, influencing its plasma levels or additive cardiac effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may markedly increase ivabradine exposure.
  • Other bradycardic agents (beta‑blockers, digoxin, diltiazem, verapamil): risk of excessive heart‑rate reduction.
  • Drugs that prolong AV conduction (e.g., amiodarone): can precipitate severe bradyarrhythmias.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce ivabradine effectiveness.
  • Antihypertensive agents (e.g., ACE inhibitors, diuretics): monitor blood pressure and heart rate.
  • Concomitant use with QT‑prolonging drugs: observe for arrhythmias.

Frequently Asked Questions

Iwabradyna Synthon contains ivabradine, which is prescribed to lower heart rate in patients with chronic stable angina and in those with heart failure with reduced ejection fraction, helping to reduce symptoms and improve functional capacity.

Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, slowing the spontaneous depolarisation of pacemaker cells. This reduces heart rate without affecting contractility or blood pressure, decreasing myocardial oxygen demand.

The appropriate dose of ivabradine is determined by the prescribing clinician based on the individual patient's condition, heart‑rate response, and tolerability. Specific dosing regimens are not provided here.

Safety data for ivabradine during pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine acts selectively on the If channel without affecting blood pressure or myocardial contractility, making it useful when beta‑blockers are contraindicated or insufficient. Beta‑blockers also provide additional anti‑adrenergic effects.

Store the product at room temperature, below 25 °C, in the original packaging. Protect it from moisture, light and excessive heat to maintain stability and potency.

The medication is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

Serious adverse events include severe bradycardia, symptomatic hypotension, atrial fibrillation, visual disturbances that may progress to visual loss, and rare cases of cardiac arrest. Patients should be monitored for these signs, especially during treatment initiation.

Ivabradine is contraindicated in patients with severe hepatic impairment, sick sinus syndrome, second‑ or third‑degree atrioventricular block, uncontrolled hypotension, or those taking strong CYP3A4 inhibitors. It should also be avoided in individuals with known hypersensitivity to the drug.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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