Product image of Izba (Travoprost) supplied by GNH India

Izba

Active Ingredient:
Travoprost
Origin:
EU

Izba (Travoprost)

Travoprost, the active ingredient in Izba, is a prostaglandin analog presented as an ophthalmic solution for ocular use. It works by increasing uveoscleral outflow of aqueous humor, thereby reducing intra‑ocular pressure. The medication is indicated for adults diagnosed with primary open‑angle glaucoma or ocular hypertension.

GNH India supplies Izba as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide, and supporting global procurement needs with regulatory expertise and reliable logistics.

Manufacturer / TM Owner

Novartis Europharm Limited

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Indications & Clinical Uses

Travoprost is a prostaglandin analog used to manage conditions characterized by elevated intra‑ocular pressure.

  • Primary open-angle glaucoma: reduces intra‑ocular pressure to slow disease progression.
  • Ocular hypertension: lowers intra‑ocular pressure to prevent development of glaucoma.
  • Normal‑tension glaucoma: helps maintain target pressure to protect optic nerve health.

How It Works

  • Travoprost binds to prostaglandin F (FP) receptors on the ciliary muscle, activating a cascade that remodels extracellular matrix and enhances uveoscleral outflow of aqueous humor. This increased outflow lowers intra‑ocular pressure, addressing the primary pathogenic factor in glaucoma and ocular hypertension.

Side Effects

Travoprost may cause ocular and systemic reactions.

Common Side Effects

  • Eye redness: mild conjunctival hyperemia.
  • Eye irritation: burning or stinging sensation after instillation.
  • Blurred vision: transient visual disturbance.
  • Increased eyelash growth: longer, thicker lashes.
  • Darkening of iris: gradual pigmentation change.
  • Eye pain: mild discomfort.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, rash, or difficulty breathing.
  • Uveitis: inflammation of the uveal tract.
  • Macular edema: swelling of the central retina.
  • Vision loss: sudden decrease in visual acuity.
  • Ocular infection: signs of bacterial or fungal infection.

Precautions & Warnings

When prescribing Travoprost, consider the following safety measures.

  • Pregnancy: safety not established; avoid unless benefits outweigh risks.
  • Breastfeeding: unknown excretion; consider potential infant exposure.
  • Contraindications: active ocular infection or inflammation.
  • Monitoring: check intra‑ocular pressure regularly after starting therapy.
  • Contact lens wearers: remove lenses before instillation and wait before reinserting.
  • Store at room temperature: keep bottle in original container, protect from light and moisture.

Avoid Interactions

Travoprost may interact with other ocular or systemic agents.

Major Interactions (Avoid)

  • Concomitant prostaglandin analog eye drops: increased risk of ocular adverse effects.
  • Non‑steroidal anti‑inflammatory eye drops: may reduce Travoprost efficacy.
  • Systemic carbonic anhydrase inhibitors: additive intra‑ocular pressure lowering, requiring close monitoring.

Moderate Interactions (Monitor Closely)

  • Beta‑blocker eye drops: additive pressure reduction, monitor IOP.
  • Corticosteroid eye drops: may diminish Travoprost's IOP‑lowering effect.
  • Alpha‑agonist eye drops: possible additive effect on pressure reduction.

Frequently Asked Questions

Izba contains travoprost, a prostaglandin analog indicated for the reduction of intra‑ocular pressure in adults with primary open‑angle glaucoma or ocular hypertension. Lowering pressure helps slow disease progression and reduces the risk of optic nerve damage.

Travoprost activates prostaglandin F (FP) receptors in the eye, triggering remodeling of the extracellular matrix in the ciliary muscle. This enhances uveoscleral outflow of aqueous humor, thereby decreasing intra‑ocular pressure, which is the primary therapeutic goal in glaucoma management.

The prescribed dose of Izba is determined by the treating ophthalmologist. Typically, one drop is instilled into the affected eye(s) once daily in the evening, but the exact regimen should follow the prescriber’s instructions and the patient’s clinical response.

Safety of travoprost in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To order Izba, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The most common alternative is latanoprost, another prostaglandin analog. Both agents lower intra‑ocular pressure by increasing uveoscleral outflow, but individual response and side‑effect profiles can differ. Some patients may experience less iris darkening with travoprost, while others may prefer latanoprost’s dosing convenience.

Izba should be stored at room temperature, below 25 °C, in its original bottle. Keep the container tightly closed, protect it from light and moisture, and avoid freezing. Do not refrigerate unless specifically instructed by the supplier.

Izba is applied as an ophthalmic solution. The patient should wash hands, tilt the head back, pull down the lower eyelid, and place one drop into the conjunctival sac of the prescribed eye(s). Close the eye gently for a few seconds and avoid touching the tip of the bottle to any surface.

Serious risks, though rare, include severe allergic reactions, uveitis, macular edema, and sudden vision loss. Patients should seek immediate medical attention if they experience intense eye pain, swelling, vision changes, or systemic allergic symptoms such as rash or difficulty breathing.

Izba is contraindicated in patients with active ocular infections, inflammation, or known hypersensitivity to travoprost or any component of the formulation. Caution is also advised for individuals with a history of severe ocular inflammation or those who cannot safely administer eye drops.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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