Product image of Jacoprazole (Lansoprazole) supplied by GNH India

Jacoprazole

Active Ingredient:
Lansoprazole
Origin:
EU

Jacoprazole (Lansoprazole)

Lansoprazole, the active ingredient in Jacoprazole, is a proton pump inhibitor presented as an oral dosage form for oral use. It reduces gastric acid secretion and is used to treat gastro‑oesophageal reflux disease, erosive oesophagitis, peptic ulcer disease and Helicobacter pylori infection in adult patients.

GNH India supplies Jacoprazole as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Jacoprazole (lansoprazole) is a proton pump inhibitor used to manage acid‑related gastrointestinal disorders.

  • Gastro‑oesophageal reflux disease (GERD): provides symptomatic relief by reducing gastric acid exposure to the esophagus.
  • Erosive oesophagitis: promotes healing of damaged esophageal mucosa through acid suppression.
  • Peptic ulcer disease: facilitates ulcer healing and prevents recurrence by maintaining a low‑acid environment.
  • Helicobacter pylori eradication regimen: acts as a component of combination therapy to increase eradication rates by decreasing gastric acidity.

How It Works

  • Lansoprazole selectively and irreversibly inhibits the H+/K+ ATPase enzyme (proton pump) located on the secretory surface of gastric parietal cells. By blocking this final step of acid production, it markedly reduces both basal and stimulated gastric acid secretion, leading to an increased gastric pH and allowing healing of acid‑related mucosal damage.

Side Effects

Adverse reactions may occur with any dosage form of lansoprazole.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhea: watery stools, usually transient.
  • Abdominal pain: discomfort or cramping in the stomach area.
  • Nausea: feeling of queasiness, sometimes with vomiting.

Serious or Rare Side Effects

  • Severe allergic reactions (anaphylaxis): rash, swelling, difficulty breathing.
  • Clostridioides difficile infection: persistent diarrhea, abdominal pain.
  • Low magnesium levels (hypomagnesemia): muscle cramps, irregular heartbeat.
  • Liver enzyme elevation: signs of hepatitis, jaundice.
  • Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.
  • Interstitial nephritis: kidney inflammation, reduced urine output.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Renal function assessment: adjust use in patients with severe renal impairment.
  • Magnesium monitoring: check serum magnesium during prolonged treatment.
  • Elderly patients: use caution due to higher risk of fractures.
  • Rebound acid hypersecretion: avoid abrupt discontinuation after long‑term use.
  • Concomitant medication review: assess for potential drug interactions.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lansoprazole may affect the pharmacokinetics of several co‑administered drugs.

Major Interactions (Avoid)

  • Clarithromycin: increased risk of cardiac arrhythmias.
  • Ketoconazole: markedly reduced antifungal absorption.
  • Atazanavir: decreased antiviral efficacy.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible alteration of anticoagulant effect.
  • Digoxin: potential increase in serum levels.
  • Methotrexate: reduced clearance leading to toxicity.

Frequently Asked Questions

Jacoprazole contains lansoprazole, a proton pump inhibitor indicated for the treatment of gastro‑oesophageal reflux disease, erosive oesophagitis, peptic ulcer disease and as part of combination therapy for Helicobacter pylori eradication. It is prescribed to reduce gastric acidity and promote healing of acid‑related gastrointestinal lesions.

Lansoprazole works by irreversibly binding to the H+/K+ ATPase enzyme, also known as the gastric proton pump, on the secretory surface of parietal cells. This inhibition blocks the final step of gastric acid production, leading to a sustained increase in gastric pH and reduction of acid‑mediated damage.

The appropriate dose of Jacoprazole is determined by the prescribing healthcare professional based on the specific indication, severity of disease, patient age and renal or hepatic function. Patients should follow the dosage instructions provided by their prescriber and not adjust the dose on their own.

Safety data for lansoprazole in pregnancy and lactation are limited, and the product does not have a defined pregnancy category. Healthcare providers should weigh the potential benefits against possible risks before prescribing Jacoprazole to pregnant or nursing women.

To order Jacoprazole, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Both Jacoprazole (lansoprazole) and omeprazole belong to the proton pump inhibitor class and provide similar acid‑suppression effects. Lansoprazole may have a slightly faster onset of action and a marginally longer half‑life, but clinical efficacy and safety profiles are comparable. Choice often depends on physician preference, patient response and formulary considerations.

Jacoprazole should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid environments such as bathrooms.

Jacoprazole is taken orally, usually with a glass of water. It can be administered with or without food, but consistent timing each day helps maintain steady acid control. Swallow tablets or capsules whole; do not crush or chew unless specifically instructed by a healthcare professional.

Serious adverse events, although rare, include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated diarrhea, low magnesium levels, liver enzyme elevations, Stevens‑Johnson syndrome and interstitial nephritis. Patients should seek immediate medical attention if they experience rash, persistent diarrhea, muscle cramps, jaundice or signs of kidney dysfunction.

Jacoprazole is contraindicated in patients with known hypersensitivity to lansoprazole or any component of the formulation. Caution is advised for individuals with severe liver disease, those taking medications that require an acidic environment for absorption, and patients with a history of osteoporosis‑related fractures when used long‑term.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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