Product image of Jadelle (Levonorgestrel) supplied by GNH India

Jadelle

Active Ingredient:
Levonorgestrel
Origin:
EU

Jadelle (Levonorgestrel)

Levonorgestrel, the active ingredient in Jadelle, is a progestin presented as an implant for subcutaneous use. It prevents pregnancy in women of reproductive age by providing long‑acting hormonal contraception.
GNH India supplies Jadelle as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Oy

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Indications & Clinical Uses

  • Levonorgestrel is a progestin used in hormonal contraception to prevent pregnancy.
  • Contraception: provides a long‑acting reversible birth control method for up to five years.
  • Family planning: offers a reliable option for women seeking sustained pregnancy prevention.
  • Prevention of pregnancy: delivers continuous progestogenic activity to inhibit ovulation and fertilisation.

How It Works

  • Levonorgestrel binds to progesterone receptors in the hypothalamus and pituitary, suppressing the luteinising hormone surge and thereby inhibiting ovulation. It also induces cervical mucus thickening and alters the endometrial lining, creating an environment unsuitable for sperm penetration and implantation.

Side Effects

Levonorgestrel implants are generally well tolerated, but some users experience adverse reactions.

Common Side Effects

  • Irregular vaginal bleeding or spotting
  • Amenorrhea (absence of periods)
  • Headache
  • Weight gain
  • Acne or skin changes
  • Mood swings or irritability

Serious or Rare Side Effects

  • Ectopic pregnancy
  • Severe allergic reaction (anaphylaxis)
  • Infection at the insertion site
  • Pelvic inflammatory disease
  • Deep vein thrombosis or other thromboembolic events

Precautions & Warnings

  • Before implantation, clinicians should evaluate patient suitability and counsel on expected outcomes.
  • Screen for contraindications: ensure no history of thromboembolic disorders, liver disease, or hormone‑sensitive cancers.
  • Assess menstrual history: discuss potential changes in bleeding patterns.
  • Monitor insertion site: watch for signs of infection or improper placement.
  • Consider drug interactions: review concurrent medications that may affect hormonal efficacy.
  • Provide counseling on side effects: inform patients about common and serious adverse events.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel implants may have altered effectiveness when used with certain medicines.

Major Interactions (Avoid)

  • Enzyme‑inducing antiepileptics (e.g., carbamazepine, phenytoin): may markedly reduce contraceptive efficacy.
  • Rifampicin or rifabutin: can lower plasma levonorgestrel levels.
  • Griseofulvin: may diminish hormonal activity.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., tetracycline, ampicillin): may slightly decrease effectiveness.
  • Antiretroviral drugs (e.g., efavirenz): may reduce hormone concentrations.
  • St. John’s wort (hypericum perforatum): may modestly lower contraceptive reliability.

Frequently Asked Questions

Jadelle is a subcutaneous implant that delivers levonorgestrel, a progestin hormone, to provide long‑acting reversible contraception. It is indicated for the prevention of pregnancy in women of reproductive age and can remain effective for up to five years after insertion.

Levonorgestrel binds to progesterone receptors, suppressing the luteinising hormone surge and preventing ovulation. It also thickens cervical mucus and modifies the endometrial lining, creating conditions that hinder sperm movement and implantation, thereby reducing the chance of pregnancy.

The dosing regimen for Jadelle is determined by a qualified prescriber. Typically, two rods are inserted subcutaneously, each containing a fixed amount of levonorgestrel that releases hormone continuously for several years. The exact number and placement are set by the healthcare professional.

Jadelle is intended for use in women who are not pregnant. If pregnancy occurs, the implant should be removed promptly. Limited data exist on its safety during breastfeeding, but most guidelines advise that women can continue breastfeeding while using the implant, as systemic exposure is low.

To order Jadelle, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Compared with oral contraceptive pills, Jadelle offers a longer duration of action (up to five years) and eliminates the need for daily adherence. Unlike injectable progestins, it provides a steady, low‑dose release without the peaks and troughs associated with periodic injections.

Jadelle should be stored at ambient temperature, below 25 °C, in its original sealed packaging. Protect the implants from moisture, direct sunlight and extreme temperature fluctuations to maintain product integrity until the time of insertion.

A trained healthcare professional inserts two Jadelle rods subcutaneously, usually in the inner side of the upper arm. The procedure is performed under aseptic conditions, and the insertion sites are covered with a small dressing after placement.

Serious risks, though rare, include ectopic pregnancy, severe allergic reactions, infection at the insertion site, pelvic inflammatory disease, and thromboembolic events such as deep‑vein thrombosis. Patients should seek immediate medical attention if they experience symptoms suggestive of these conditions.

Jadelle is contraindicated in women with a known or suspected pregnancy, active breast cancer, unexplained vaginal bleeding, severe liver disease, or a history of thromboembolic disorders. It should also be avoided in individuals with hypersensitivity to levonorgestrel or any component of the implant.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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