Product image of Jadelle (Levonorgestrel) supplied by GNH India

Jadelle

Active Ingredient:
Levonorgestrel
Origin:
EU

Jadelle (Levonorgestrel)

Levonorgestrel, the active ingredient in Jadelle, is a progestin presented as a 150 mg total (2 × 75 mg rods) subdermal implant for subcutaneous use. It provides long‑acting reversible contraception by preventing ovulation and implantation in women of reproductive age.

GNH India supplies Jadelle as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and offers reliable global logistics for this contraceptive device, providing consistent batch release, regulatory support, and dedicated technical assistance.

Manufacturer / TM Owner

Bayer Portugal Lda

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Indications & Clinical Uses

Levonorgestrel is a progestin used in hormonal contraception to provide long‑acting reversible birth control.

  • Contraception: Provides up to five years of pregnancy prevention for women seeking a reliable, reversible method.
  • Family planning: Enables effective birth control without daily dosing, supporting long‑term reproductive planning.
  • Prevention of unintended pregnancy: Reduces the risk of unintended pregnancy in sexually active women.

How It Works

  • Levonorgestrel binds to progesterone receptors in the hypothalamus and pituitary, suppressing the luteinizing hormone (LH) and follicle‑stimulating hormone (FSH) surge, thereby inhibiting ovulation. It also thickens cervical mucus to impede sperm penetration and induces endometrial changes that reduce the likelihood of implantation.

Side Effects

Levonorgestrel implants may cause a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Insertion site pain: Discomfort or soreness at the implant insertion site.
  • Irregular bleeding: Spotting, prolonged bleeding, or amenorrhea.
  • Headache: Mild to moderate headache episodes.
  • Acne: New or worsening acne lesions.

Serious or Rare Side Effects

  • Ectopic pregnancy: Pregnancy occurring outside the uterus despite implant use.
  • Pelvic inflammatory disease: Infection of the reproductive organs.
  • Implant migration: Movement of the rod from the original insertion site.
  • Allergic reaction: Rash, swelling, or anaphylaxis in response to the device.

Precautions & Warnings

Before using Jadelle, certain precautions should be observed to ensure safety and effectiveness.

  • Pregnancy testing: Verify non‑pregnant status prior to insertion.
  • Breastfeeding: Discuss potential risks with a healthcare professional before placement.
  • Hormone‑sensitive conditions: Avoid use in women with a history of breast cancer or estrogen‑dependent tumors.
  • Medication interactions: Review concomitant drugs that may reduce contraceptive efficacy.
  • Follow‑up: Schedule regular visits to assess implant position and bleeding patterns.
  • Store at ambient temperature: Keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel implants can interact with other medicines, affecting their effectiveness or safety.

Major Interactions (Avoid)

  • Enzyme inducers (e.g., rifampicin, carbamazepine): May significantly lower levonorgestrel levels, reducing contraceptive protection.
  • Antiretroviral drugs (e.g., efavirenz): Can decrease hormone concentrations and increase risk of unintended pregnancy.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles (e.g., ketoconazole): May increase levonorgestrel exposure, potentially enhancing side effects.
  • Certain antibiotics (e.g., ampicillin): Generally minimal effect but should be monitored for any changes in bleeding.
  • Herbal supplements (e.g., St. John’s wort): May induce metabolism and lower implant efficacy.

Frequently Asked Questions

Jadelle is a subdermal contraceptive system that provides long‑acting reversible birth control. It is indicated for prevention of pregnancy in women of reproductive age and can remain effective for up to five years after insertion.

Levonorgestrel released from the implant binds to progesterone receptors, suppressing the hormonal signals that trigger ovulation. It also thickens cervical mucus and alters the endometrial lining, creating multiple barriers that prevent sperm entry and implantation.

Jadelle contains a total of 150 mg of levonorgestrel delivered via two 75 mg rods. The exact dosing schedule, including insertion and any future removal, is determined by the prescribing healthcare professional based on individual patient needs.

Jadelle is contraindicated in pregnancy (Category X) and should not be inserted in a pregnant woman. For breastfeeding women, the benefits and risks should be discussed with a clinician, as levonorgestrel does pass into breast milk in low amounts.

To order Jadelle, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with daily oral pills, Jadelle offers continuous protection without the need for daily adherence. Relative to other implants such as Nexplanon (etonogestrel), Jadelle provides a similar duration of action but uses levonorgestrel, which may have a different side‑effect profile and hormone exposure.

Jadelle should be stored at ambient temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight and physical damage until the time of insertion by a qualified professional.

Jadelle is inserted subdermally by a trained healthcare provider. Two flexible rods are placed under the skin of the upper arm through a minor surgical procedure, after which the insertion site is closed and a brief observation period follows.

Serious risks include ectopic pregnancy if conception occurs, pelvic inflammatory disease, migration of the implant from its original position, and rare allergic reactions that may present as rash, swelling or anaphylaxis. Prompt medical attention is required if any of these occur.

Jadelle should not be used by women who are currently pregnant, have a known hypersensitivity to levonorgestrel, have active liver disease, or have a history of hormone‑sensitive cancers such as breast or endometrial carcinoma. Contraindications should be confirmed by a healthcare professional before insertion.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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