Product image of Jadelle Sine Inserter (Levonorgestrel) supplied by GNH India

Jadelle Sine Inserter

Active Ingredient:
Levonorgestrel
Origin:
EU

Jadelle Sine Inserter (Levonorgestrel)

Levonorgestrel, the active ingredient in Jadelle Sine Inserter, is a progestogen presented as a subcutaneous implant for subcutaneous use. It provides long‑acting reversible contraception for women of reproductive age.

GNH India supplies Jadelle Sine Inserter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Oy

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Indications & Clinical Uses

Levonorgestrel is used as a hormonal contraceptive to prevent unintended pregnancy.

  • Contraception: Provides continuous prevention of pregnancy for up to five years after insertion.
  • Family planning: Enables women to plan pregnancies with a reliable, low‑maintenance method.
  • Post‑abortion contraception: Allows immediate initiation of long‑term birth control following an abortion procedure.

How It Works

  • Levonorgestrel binds to progesterone receptors in the hypothalamus and pituitary, suppressing the luteinizing hormone surge and thereby preventing ovulation. It also thickens cervical mucus, creating a barrier to sperm penetration, and induces endometrial changes that reduce the likelihood of implantation, resulting in effective, long‑acting contraception.

Side Effects

Levonorgestrel implants may cause a range of adverse reactions.

Common Side Effects

  • Irregular vaginal bleeding or spotting
  • Amenorrhea (absence of periods)
  • Headache
  • Acne or skin changes
  • Weight gain or mild fluid retention
  • Mood swings or depressive symptoms

Serious or Rare Side Effects

  • Ectopic pregnancy if implantation occurs outside the uterus
  • Pelvic inflammatory disease
  • Insertion site infection or abscess
  • Device migration or expulsion
  • Severe allergic reaction (anaphylaxis)
  • Thromboembolic events (rare)

Precautions & Warnings

Before using Jadelle Sine Inserter, certain precautions should be observed.

  • Pregnancy testing: Confirm the patient is not pregnant prior to insertion.
  • Breastfeeding: Discuss potential risks and benefits with a healthcare professional.
  • Medication review: Evaluate concurrent drugs that may affect hormonal activity.
  • Medical history: Assess for clotting disorders, liver disease, or hormone‑sensitive cancers.
  • Follow‑up care: Schedule regular visits to check implant position and monitor side effects.
  • Store at ambient temperature: Keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel implants can interact with other medicines, requiring attention to avoid reduced efficacy or increased risk.

Major Interactions (Avoid)

  • Combined hormonal contraceptives: Concurrent use may increase hormonal load.
  • Enzyme‑inducing antiepileptics (e.g., carbamazepine, phenytoin): May lower contraceptive effectiveness.
  • Rifampin or other strong inducers: Can significantly reduce levonorgestrel levels.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles (e.g., ketoconazole): May increase hormone concentrations.
  • Protease inhibitor antiretrovirals: May alter metabolism of levonorgestrel.
  • St. John’s wort (herbal supplement): Potentially decreases contraceptive efficacy.

Frequently Asked Questions

Jadelle Sine Inserter is a subcutaneous implant that delivers levonorgestrel for long‑acting reversible contraception. It is intended to prevent pregnancy in women of reproductive age for up to five years after a single insertion by a qualified healthcare professional.

Levonorgestrel released from the implant binds to progesterone receptors, suppressing ovulation, thickening cervical mucus to block sperm entry, and altering the uterine lining to make implantation unlikely. These combined actions provide continuous contraceptive protection without daily dosing.

The dosage and number of implants are determined by the prescribing clinician based on the approved product specifications and the patient’s individual health profile. The prescriber decides the appropriate regimen at the time of insertion.

Jadelle Sine Inserter is contraindicated in pregnancy (Category X) and should not be inserted in a pregnant woman. Women who are breastfeeding should discuss potential risks with their healthcare provider, as hormonal exposure may affect milk production and infant exposure.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Compared with daily oral pills, Jadelle offers a once‑in‑a‑lifetime insertion that provides up to five years of protection, eliminating the need for daily adherence. Unlike intrauterine devices, it does not require uterine placement and can be removed easily if fertility is desired sooner.

The implant should be stored at ambient temperature, below 25 °C, in its original sealed packaging. Protect it from moisture, direct sunlight, and extreme temperatures to maintain product integrity until the time of insertion.

A qualified healthcare professional inserts the implant subcutaneously in the inner side of the upper arm using a pre‑filled inserter device. The procedure is minimally invasive, takes only a few minutes, and does not require anesthesia in most cases.

Serious risks include ectopic pregnancy, pelvic inflammatory disease, insertion‑site infection, device migration or expulsion, severe allergic reactions, and rare thromboembolic events. Patients should seek immediate medical attention if they experience severe abdominal pain, unusual bleeding, or signs of infection.

Women who are currently pregnant, have a known hypersensitivity to levonorgestrel, have active liver disease, a history of thromboembolic disorders, hormone‑sensitive cancers, or untreated abnormal uterine bleeding should avoid using this implant. A thorough medical evaluation is required before insertion.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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