Product image of Janumet (Metformin Hydrochloride, Sitagliptin) supplied by GNH India

Janumet

Active Ingredient:
Metformin Hydrochloride, Sitagliptin
Origin:
EU

Janumet (Metformin Hydrochloride, Sitagliptin)

Metformin Hydrochloride and Sitagliptin, the active ingredients in Janumet, are a biguanide and a DPP‑4 inhibitor presented as a tablet for oral use. It treats type 2 diabetes mellitus in adults by improving glycaemic control.
GNH India supplies Janumet as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Merck Sharp & Dohme B.V.

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Indications & Clinical Uses

Janumet is indicated for the management of type 2 diabetes mellitus, often in combination with diet and exercise.

  • Type 2 diabetes mellitus: improves overall blood glucose control.
  • Inadequate response to metformin alone: provides additional glycaemic lowering when metformin monotherapy is insufficient.
  • Target HbA1c reduction: helps patients achieve recommended HbA1c goals as part of a comprehensive diabetes management plan.

How It Works

  • Metformin reduces hepatic glucose production and enhances peripheral insulin sensitivity, while sitagliptin inhibits the dipeptidyl peptidase‑4 enzyme, increasing endogenous incretin levels and promoting glucose‑dependent insulin secretion. Together they address both insulin resistance and impaired insulin release, resulting in improved glycaemic control in type 2 diabetes.

Side Effects

Janumet may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Diarrhoea: loose stools, often transient.
  • Abdominal discomfort: cramping or pain.
  • Headache: mild persistent headache.
  • Decreased appetite: reduced desire to eat.
  • Mild hypoglycaemia: especially when combined with other glucose‑lowering agents.

Serious or Rare Side Effects

  • Lactic acidosis: rare but life‑threatening metabolic complication.
  • Pancreatitis: severe inflammation of the pancreas.
  • Severe allergic reactions: rash, angioedema, or anaphylaxis.
  • Hepatic failure: marked liver dysfunction.
  • Persistent severe hypoglycaemia: prolonged low blood glucose levels.
  • Renal impairment worsening: decline in kidney function.

Precautions & Warnings

Before initiating Janumet, several safety considerations should be reviewed.

  • Renal function: assess creatinine clearance and avoid use in severe renal impairment.
  • Hepatic disease: use with caution in patients with liver dysfunction.
  • Risk of lactic acidosis: monitor for symptoms in patients with conditions predisposing to hypoxia.
  • Pregnancy and lactation: discuss potential risks with a healthcare professional.
  • Concomitant medications: review all drugs for possible interactions.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, and protect from moisture.

Avoid Interactions

Janumet can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Severe renal impairment: contraindicated due to increased metformin accumulation.
  • Iodinated contrast agents: may precipitate renal dysfunction; discontinue before imaging.
  • Strong CYP2C8 inhibitors (e.g., gemfibrozil): raise sitagliptin levels, increasing risk of adverse effects.
  • Sulfonylureas or insulin: may cause profound hypoglycaemia.
  • Excessive alcohol: heightens risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect renal function, requiring monitoring.
  • Beta‑blockers: can mask hypoglycaemia symptoms.
  • ACE inhibitors or ARBs: monitor renal parameters when combined.

Frequently Asked Questions

Janumet is prescribed for adults with type 2 diabetes mellitus to improve blood glucose control. It combines metformin, which reduces liver glucose output and enhances insulin sensitivity, with sitagliptin, which boosts insulin secretion in response to meals. The combination helps achieve target HbA1c levels when diet, exercise, and monotherapy are insufficient.

Metformin Hydrochloride lowers blood sugar primarily by inhibiting hepatic gluconeogenesis, reducing the amount of glucose produced by the liver. It also increases peripheral tissue sensitivity to insulin, facilitating glucose uptake into muscles and fat cells, thereby contributing to overall glycaemic control.

The specific dose of Janumet is determined by the prescribing healthcare professional based on individual patient factors such as renal function, current glycaemic control, and concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

The safety of Janumet in pregnancy and lactation has not been definitively established. Healthcare providers will weigh potential benefits against risks and may recommend alternative therapies. Women who are pregnant, planning pregnancy, or breastfeeding should discuss treatment options with their physician.

To place an order, submit an enquiry on the Janumet product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details, and any necessary import documentation.

Janumet offers a dual mechanism by combining a biguanide (metformin) with a DPP‑4 inhibitor (sitagliptin), providing both insulin‑sensitising and insulin‑secretagogue effects. Compared with metformin alone, it can achieve greater HbA1c reduction, and unlike sulfonylureas, it carries a lower risk of hypoglycaemia while avoiding weight gain associated with some other agents.

Janumet tablets should be stored at ambient temperature, preferably below 25 °C. Keep the medication in its original packaging to protect it from moisture and light. Do not store in bathrooms or near heat sources, and keep out of reach of children.

Janumet is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablet should be swallowed whole with a glass of water. Patients must follow the dosing schedule prescribed by their healthcare provider and should not crush or chew the tablet.

The most serious risks include lactic acidosis, a rare but potentially fatal condition linked to metformin accumulation, and pancreatitis, which can be associated with sitagliptin. Patients should seek immediate medical attention if they experience unexplained muscle pain, rapid breathing, abdominal pain, or persistent vomiting.

Janumet is contraindicated in patients with severe renal impairment, known hypersensitivity to metformin or sitagliptin, and those with a history of lactic acidosis. It should also be avoided in individuals with acute or chronic metabolic acidosis, including diabetic ketoacidosis, until the underlying condition is resolved.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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