Product image of Jardiance (Empagliflozin) supplied by GNH India

Jardiance

Active Ingredient:
Empagliflozin
Origin:
EU

Jardiance (Empagliflozin)

Empagliflozin, the active ingredient in Jardiance, is a Sodium‑glucose co‑transporter 2 (SGLT2) inhibitor presented as a tablet for oral use. It is prescribed to improve glycaemic control in adults with type 2 diabetes mellitus, to lower cardiovascular death in those with established cardiovascular disease, and to treat heart failure with reduced ejection fraction.

GNH India supplies Jardiance as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and providing regulated distribution to qualified healthcare institutions.

Manufacturer / TM Owner

Boehringer Ingelheim International Gmbh

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Indications & Clinical Uses

Jardiance, an SGLT2 inhibitor, is used in several metabolic and cardiovascular conditions.

  • Type 2 diabetes mellitus: improves glycaemic control and reduces HbA1c levels.
  • Cardiovascular disease in adults with type 2 diabetes: lowers risk of cardiovascular death.
  • Heart failure with reduced ejection fraction: decreases cardiovascular death and heart‑failure hospitalisation.

How It Works

  • Empagliflozin selectively inhibits the sodium‑glucose co‑transporter 2 (SGLT2) located in the proximal renal tubules, reducing renal glucose reabsorption. The resulting increase in urinary glucose excretion lowers plasma glucose concentrations, while accompanying osmotic diuresis and natriuresis contribute to modest reductions in blood pressure and body weight.

Side Effects

Empagliflozin may cause a range of adverse reactions, which are grouped by frequency and severity.

Common Side Effects

  • Genital mycotic infection: increased risk of yeast infections.
  • Urinary tract infection: symptoms of dysuria or frequency.
  • Increased urination: polyuria leading to nocturia.
  • Thirst: heightened fluid intake.
  • Hypotension: especially in patients on diuretics.
  • Nausea: mild gastrointestinal upset.

Serious or Rare Side Effects

  • Diabetic ketoacidosis: metabolic acidosis with normal or low glucose.
  • Acute kidney injury: sudden decline in renal function.
  • Severe dehydration: due to excessive fluid loss.
  • Fournier's gangrene: necrotizing fasciitis of the perineum.
  • Severe allergic reactions: rash, angioedema, anaphylaxis.
  • Hypoglycaemia: when combined with insulin or insulin secretagogues.

Precautions & Warnings

When prescribing empagliflozin, clinicians should consider several safety aspects.

  • Renal function monitoring: avoid in patients with severe renal impairment.
  • Volume depletion risk: assess hydration status, especially in the elderly.
  • Ketoacidosis vigilance: educate patients on signs of euglycaemic ketoacidosis.
  • Pregnancy and lactation: safety not established; use only if benefits outweigh risks.
  • Concomitant diuretics: monitor for additive hypotensive effects.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Empagliflozin can interact with other medicines, requiring attention to the level of risk.

Major Interactions (Avoid)

  • Insulin or insulin secretagogues: increased risk of hypoglycaemia.
  • Loop diuretics: may exacerbate volume depletion.
  • Other SGLT2 inhibitors: duplicate pharmacologic effect.

Moderate Interactions (Monitor Closely):\n- ACE inhibitors or ARBs: additive blood‑pressure lowering.

  • NSAIDs: potential impact on renal function.
  • Rifampin: may reduce empagliflozin exposure.
  • Thiazide diuretics: further diuretic effect.

Frequently Asked Questions

Jardiance (empagliflozin) is indicated for adults with type 2 diabetes mellitus to improve glycaemic control, for patients with established cardiovascular disease to reduce the risk of cardiovascular death, and for those with heart failure with reduced ejection fraction to lower the risk of cardiovascular death and hospitalisation.

Empagliflozin blocks the sodium‑glucose co‑transporter 2 (SGLT2) in the kidney’s proximal tubules, preventing glucose reabsorption. The excess glucose is expelled in the urine, which lowers blood glucose levels and also produces modest diuretic and natriuretic effects that can aid blood‑pressure control.

The dose of Jardiance is individualized by the prescribing healthcare professional based on the patient’s clinical condition, renal function, and concomitant therapies. The prescriber determines the appropriate starting dose and any subsequent titration according to current clinical guidelines.

Safety of empagliflozin in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To request Jardiance, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Jardiance belongs to the same drug class as canagliflozin, dapagliflozin and ertugliflozin. All share the core mechanism of SGLT2 inhibition, but clinical trials have shown Jardiance to have a robust cardiovascular‑mortality benefit in patients with established cardiovascular disease, a distinction highlighted in its label.

Store Jardiance tablets at ambient temperature, below 25 °C (77 °F). Keep the product in its original blister pack or container, protect it from moisture and direct sunlight, and discard any tablets that are visibly damaged or past the expiry date.

Jardiance is taken orally as a tablet, swallowed whole with a glass of water. It may be taken with or without food, and the dosing schedule (once daily) is set by the prescriber based on the patient’s therapeutic needs.

The most serious risks include diabetic ketoacidosis (which can occur with normal or low blood glucose), acute kidney injury, severe dehydration, and rare but life‑threatening infections such as Fournier’s gangrene. Patients should seek immediate medical attention if they experience symptoms such as nausea, vomiting, abdominal pain, rapid breathing, or unusual genital pain.

Jardiance is contraindicated in patients with a known hypersensitivity to empagliflozin or any component of the formulation, in those with severe renal impairment (eGFR < 30 mL/min/1.73 m²), and in individuals on dialysis. Caution is also advised for patients with a history of recurrent genital or urinary tract infections.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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