Product image of Jatrosom (Tranylcypromine) supplied by GNH India

Jatrosom

Active Ingredient:
Tranylcypromine
Origin:
EU

Jatrosom (Tranylcypromine)

Tranylcypromine, the active ingredient in Jatrosom, is a monoamine oxidase inhibitor presented as an oral tablet for oral use. It is prescribed for the treatment of major depressive disorder in adult patients, helping to alleviate persistent depressive symptoms by increasing the availability of key neurotransmitters in the brain.

GNH India supplies Jatrosom as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and research institutions worldwide, ensuring consistent quality, regulatory compliance and reliable supply chain support for all therapeutic needs.

Manufacturer / TM Owner

Aristo Pharma Gmbh (Art 57)

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Indications & Clinical Uses

Tranylcypromine is an MAOI antidepressant used in the management of depressive disorders.

  • Major depressive disorder: reduces depressive symptoms and improves mood in adult patients.
  • Treatment‑resistant depression: may be considered when other antidepressants have failed.
  • Atypical depression: can alleviate symptoms such as low energy and mood lability.

How It Works

  • Tranylcypromine irreversibly inhibits both monoamine oxidase A and B enzymes, preventing the breakdown of serotonin, norepinephrine and dopamine. This increases the synaptic concentrations of these neurotransmitters, enhancing neurotransmission and producing antidepressant effects.

Side Effects

Tranylcypromine may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: frequent dull or throbbing pain.
  • Insomnia: difficulty falling or staying asleep.
  • Dizziness: sensation of light‑headedness, especially on standing.
  • Dry mouth: reduced salivation.
  • Orthostatic hypotension: drop in blood pressure upon standing.

Serious or Rare Side Effects

  • Hypertensive crisis: severe high blood pressure after ingesting tyramine‑rich foods.
  • Serotonin syndrome: potentially life‑threatening condition when combined with other serotonergic agents.
  • Severe liver injury: rare hepatic toxicity.
  • Persistent severe hypotension: marked drop in blood pressure requiring medical attention.

Precautions & Warnings

Use of Tranylcypromine requires careful monitoring and patient education.

  • Avoid tyramine‑rich foods: prevent hypertensive reactions.
  • Monitor blood pressure regularly: detect orthostatic changes.
  • Assess liver function: watch for signs of hepatic toxicity.
  • Use caution in elderly patients: increased risk of falls and hypotension.
  • Discontinue before surgery: reduce risk of intra‑operative hypertensive episodes.
  • Store at ambient temperature: keep below 25 °C in the original container, protected from moisture and light.

Avoid Interactions

Tranylcypromine interacts with several drug classes and substances.

Major Interactions (Avoid)

  • Tyramine‑containing foods and beverages: can trigger hypertensive crisis.
  • Selective serotonin reuptake inhibitors (SSRIs) and SNRIs: risk of serotonin syndrome.
  • Meperidine and other opioid analgesics: may cause severe hypertension.
  • Linezolid and other MAO‑inhibiting antibiotics: increase serotonin toxicity.
  • Certain sympathomimetic agents (e.g., pseudoephedrine): elevate blood pressure.

Moderate Interactions (Monitor Closely)

  • Antihypertensive medications: may enhance hypotensive effects.
  • Over‑the‑counter cold remedies containing decongestants: monitor blood pressure and serotonin levels.

Frequently Asked Questions

Jatrosom contains the active ingredient tranylcypromine, an oral monoamine oxidase inhibitor prescribed for the treatment of major depressive disorder in adult patients, particularly when other antidepressants have not provided adequate relief.

Tranylcypromine irreversibly blocks both MAO‑A and MAO‑B enzymes, preventing the breakdown of serotonin, norepinephrine and dopamine. The resulting increase in these neurotransmitters enhances mood and alleviates depressive symptoms.

The appropriate dose of Jatrosom is determined by the prescribing clinician based on the individual patient's condition, response to therapy and safety considerations. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of tranylcypromine in pregnancy and lactation has not been established. It is generally advised to avoid use unless the potential benefit outweighs the potential risk, and this decision should be made by a qualified healthcare professional.

To request Jatrosom, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Jatrosom belongs to the MAOI class, which differs from SSRIs, SNRIs and atypical antidepressants by its mechanism of non‑selective, irreversible inhibition of monoamine oxidase. This can be effective for certain depressive subtypes but requires dietary restrictions and careful monitoring of drug interactions.

Store Jatrosom tablets at ambient temperature, preferably below 25 °C, in the original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain its stability and potency.

Jatrosom is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact timing and frequency should follow the healthcare professional’s guidance.

The most serious risks include hypertensive crisis triggered by tyramine‑rich foods, serotonin syndrome when combined with other serotonergic agents, severe hypotension, and rare cases of liver toxicity. Patients should be educated about these risks and seek immediate medical attention if they occur.

Jatrosom is contraindicated in patients with known hypersensitivity to tranylcypromine, those taking other MAO inhibitors, individuals with pheochromocytoma, severe cardiovascular disease, or uncontrolled hypertension. It should also be avoided in patients using certain serotonergic or sympathomimetic drugs.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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