Product image of Jaxteran (Dimethyl Fumarate) supplied by GNH India

Jaxteran

Active Ingredient:
Dimethyl Fumarate
Origin:
EU

Jaxteran (Dimethyl Fumarate)

Dimethyl fumarate, the active ingredient in Jaxteran, is an immunomodulator presented as an oral tablet for oral use. It treats relapsing forms of multiple sclerosis and moderate to severe plaque psoriasis in adult patients.
GNH India supplies Jaxteran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Jaxteran, an immunomodulator used in disease‑modifying therapy, is indicated for:

  • Relapsing‑remitting multiple sclerosis: reduces the frequency of clinical relapses and slows disability progression.
  • Plaque psoriasis (moderate to severe): improves skin lesions and decreases overall disease severity.

How It Works

  • Dimethyl fumarate activates the nuclear factor erythroid 2‑related factor 2 (Nrf2) pathway, leading to increased expression of antioxidant proteins, reduction of oxidative stress, and modulation of immune cell activity. These actions produce anti‑inflammatory and neuroprotective effects that help control disease activity in multiple sclerosis and psoriasis.

Side Effects

Common Side Effects

  • Flushing: transient warmth and redness, often mitigated by taking with food.
  • Gastrointestinal discomfort: nausea, abdominal pain, or diarrhea.
  • Lymphopenia: mild reduction in lymphocyte count.
  • Headache: mild to moderate intensity.
  • Upper respiratory tract infection: mild cold‑like symptoms.

Serious or Rare Side Effects

  • Progressive multifocal leukoencephalopathy (PML): rare but potentially fatal brain infection.
  • Severe lymphopenia: markedly low lymphocyte counts increasing infection risk.
  • Hepatic injury: elevated liver enzymes or hepatitis.
  • Severe allergic reactions: rash, angioedema, or anaphylaxis.
  • Stevens‑Johnson syndrome: severe skin and mucosal reactions.
  • Acute pancreatitis: rare inflammation of the pancreas.

Precautions & Warnings

Before initiating therapy, clinicians should consider the following precautions:

  • Monitor lymphocyte counts: perform regular blood tests to detect lymphopenia.
  • Assess liver function: periodic hepatic enzyme monitoring is recommended.
  • Evaluate infection risk: avoid starting treatment in patients with active infections.
  • Counsel on flushing management: advise taking the tablet with food and avoiding alcohol.
  • Pregnancy and breastfeeding: use only if potential benefits outweigh risks.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Dimethyl fumarate may interact with several drug classes:

Major Interactions (Avoid)

  • Live vaccines: contraindicated due to immunosuppressive effects.
  • Concurrent immunosuppressants (e.g., azathioprine): may increase infection risk.
  • Strong enzyme inducers (e.g., carbamazepine): may reduce dimethyl fumarate exposure.

Moderate Interactions (Monitor Closely)

  • Antacids: may affect absorption; separate dosing by at least 2 hours.
  • NSAIDs: additive gastrointestinal irritation.
  • Non‑live vaccines: possible reduced efficacy; monitor immune response.

Frequently Asked Questions

Jaxteran is prescribed for adults with relapsing forms of multiple sclerosis to reduce relapse frequency and slow disability progression, and for moderate to severe plaque psoriasis to improve skin lesions and overall disease severity.

Dimethyl fumarate activates the Nrf2 cellular pathway, enhancing antioxidant defenses and reducing oxidative stress. This modulation dampens inflammatory responses and alters immune cell activity, providing neuroprotective and anti‑inflammatory benefits in multiple sclerosis and psoriasis.

The prescribed dose of Jaxteran is determined by the treating physician based on the patient’s condition, tolerance, and clinical response. Dosage titration and maintenance schedules are individualized and should follow the prescriber’s instructions.

Safety data for dimethyl fumarate in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To request Jaxteran, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Compared with other oral disease‑modifying agents such as fingolimod, dimethyl fumarate offers a distinct mechanism via Nrf2 activation and generally has a lower risk of cardiac conduction abnormalities, but it may cause more frequent flushing and gastrointestinal symptoms. Choice of therapy depends on individual patient factors and physician assessment.

Store Jaxteran tablets at ambient temperature, preferably below 25 °C, in the original container to protect from moisture and light. Keep the medication out of reach of children and do not use if the packaging is damaged.

Jaxteran is taken orally, usually once daily, with food to lessen gastrointestinal irritation and flushing. Swallow the tablet whole with a full glass of water; do not crush or chew it.

Serious risks include progressive multifocal leukoencephalopathy (PML), severe lymphopenia leading to heightened infection susceptibility, significant liver injury, and rare severe skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored regularly for these complications.

Jaxteran is contraindicated in patients with known hypersensitivity to dimethyl fumarate, active severe infections, severe hepatic impairment, or those who are pregnant unless the benefit justifies the risk. Caution is also advised for individuals with a history of PML or severe lymphopenia.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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