Product image of Jaydess (Levonorgestrel) supplied by GNH India

Jaydess

Active Ingredient:
Levonorgestrel
Origin:
EU

Jaydess (Levonorgestrel)

Levonorgestrel, the active ingredient in Jaydess, is a progestin presented as a 13.5 mg intrauterine system for intrauterine use. It prevents pregnancy by providing hormonal contraception for women of reproductive age.

GNH India supplies Jaydess as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Ag

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Indications & Clinical Uses

Levonorgestrel delivered via the Jaydess intrauterine system is used within the hormonal contraceptive pathway to prevent unintended pregnancy.

  • Contraception: provides highly effective reversible birth control for women of child‑bearing age.
  • Extended‑duration contraception (up to 3 years): reduces the need for frequent device replacement.
  • Fertility planning: allows rapid return to fertility after device removal.

How It Works

  • Levonorgestrel released locally from the intrauterine system acts on the endometrium to suppress proliferation, thickens cervical mucus to impede sperm passage, and interferes with the hypothalamic‑pituitary‑ovarian axis to inhibit ovulation, thereby preventing pregnancy.

Side Effects

Common side effects are generally mild and related to the local hormonal release.

Common Side Effects

  • Irregular bleeding or spotting.
  • Amenorrhea (absence of periods).
  • Cramping or pelvic discomfort during or after insertion.
  • Breast tenderness.
  • Mood changes.

Serious or Rare Side Effects

  • Uterine perforation during insertion.
  • Device expulsion.
  • Pelvic inflammatory disease or infection.
  • Ectopic pregnancy if contraception fails.
  • Severe allergic reaction to device components.

Precautions & Warnings

Before insertion, clinicians should assess patient suitability and counsel on risks.

  • Contraindications: avoid in women with active pelvic infection, unexplained vaginal bleeding, or known hypersensitivity to levonorgestrel.
  • Screening: confirm non‑pregnant status and evaluate uterine anatomy.
  • Follow‑up: schedule post‑insertion check to verify placement.
  • Pregnancy monitoring: advise immediate medical review if pregnancy is suspected.
  • Medication review: consider interactions with enzyme‑inducing drugs.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel IUS may have pharmacokinetic interactions with drugs that affect steroid metabolism.

Major Interactions (Avoid)

  • Rifampin and other strong enzyme inducers.
  • Anticonvulsants such as phenytoin, carbamazepine, or phenobarbital.
  • Antiretroviral efavirenz.
  • St. John’s wort (hypericum perforatum).

Moderate Interactions (Monitor Closely)

  • Combined hormonal contraceptives used concurrently.
  • Hormone replacement therapy.
  • Certain antibiotics that may reduce contraceptive efficacy (e.g., griseofulvin).

Frequently Asked Questions

Jaydess is a levonorgestrel‑releasing intrauterine system indicated for hormonal contraception. It provides a highly effective, reversible method of birth control for women of reproductive age, preventing pregnancy for up to three years after insertion.

Levonorgestrel released from the device acts locally on the endometrium to suppress its growth, thickens cervical mucus to block sperm entry, and interferes with the hormonal signals that trigger ovulation, thereby preventing fertilisation and implantation.

Jaydess contains a fixed 13.5 mg amount of levonorgestrel within the intrauterine system. The prescribing clinician determines the appropriate use and duration; no patient‑adjusted dosing is required.

Jaydess is classified as Pregnancy Category X, meaning it must not be used by women who are pregnant. It is not recommended for breastfeeding mothers until the device is removed, as levonorgestrel may be excreted in breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Jaydess contains a lower levonorgestrel dose (13.5 mg) compared with devices such as Mirena (52 mg), offering a similar contraceptive effect with a potentially reduced hormonal side‑effect profile. Both provide long‑acting reversible contraception, but Jaydess is approved for up to three years of use.

Jaydess should be stored at ambient temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight and extreme temperature fluctuations to maintain its integrity until insertion.

Jaydess is inserted by a trained healthcare professional into the uterine cavity through the cervical canal. The procedure is performed in a clinical setting using a sterile inserter, and the device remains in place to release levonorgestrel continuously for up to three years.

Serious risks include uterine perforation during insertion, device expulsion, pelvic inflammatory disease, and the rare possibility of ectopic pregnancy if contraceptive failure occurs. Prompt medical evaluation is essential if severe abdominal pain, abnormal bleeding, or signs of infection develop.

Women with active pelvic infection, unexplained vaginal bleeding, known hypersensitivity to levonorgestrel, or a history of uterine perforation should avoid Jaydess. It is also contraindicated in pregnant women and those who are currently breastfeeding.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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