Product image of Jaydess (Levonorgestrel) supplied by GNH India

Jaydess

Active Ingredient:
Levonorgestrel
Origin:
EU

Jaydess (Levonorgestrel)

Levonorgestrel, the active ingredient in Jaydess, is a progestin presented as a 13.5 mg intrauterine system (IUS) for intrauterine use. It prevents pregnancy by providing continuous local hormone release.

GNH India supplies Jaydess as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Ab

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Indications & Clinical Uses

Levonorgestrel delivered via the intrauterine system is used in the contraceptive pathway to prevent unintended pregnancy.

  • Contraception (prevention of pregnancy): provides highly effective long‑term birth control.

How It Works

  • Levonorgestrel released from the intrauterine system binds to progesterone receptors in the cervical mucus, endometrium, and hypothalamic‑pituitary axis. This thickens cervical mucus, inhibits ovulation, and induces endometrial atrophy, thereby preventing fertilisation and implantation of a fertilised egg.

Side Effects

Levonorgestrel IUS may cause a range of adverse reactions.

Common Side Effects

  • Irregular bleeding or spotting
  • Amenorrhea (absence of periods)
  • Pelvic or lower abdominal pain
  • Cramping during or after insertion
  • Vaginal discharge
  • Headache

Serious or Rare Side Effects

  • Uterine perforation during insertion
  • Device expulsion or displacement
  • Pelvic infection (e.g., PID)
  • Ectopic pregnancy if contraception fails
  • Severe allergic reaction (rash, swelling)
  • Hormonal effects such as severe migraine or depression

Precautions & Warnings

Before insertion and during use, certain precautions should be observed.

  • Confirm non‑pregnancy: ensure patient is not pregnant prior to placement.
  • Evaluate uterine anatomy: rule out fibroids, septum, or other abnormalities.
  • Screen for infection: postpone insertion if active pelvic infection is present.
  • Assess hypersensitivity: avoid in patients with known allergy to levonorgestrel.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel IUS has limited systemic exposure, but some drug interactions may affect efficacy.

Major Interactions (Avoid)

  • Rifampicin, carbamazepine, phenytoin: enzyme inducers that may lower levonorgestrel levels.
  • Ketoconazole, itraconazole: strong antifungal agents that may increase levonorgestrel exposure.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., tetracycline): may slightly reduce contraceptive effectiveness.
  • Antiretrovirals such as efavirenz: possible reduction in hormone levels.
  • Herbal supplements like St. John's wort: may lower efficacy.
  • Hormonal therapies (combined oral contraceptives): monitor for additive hormonal effects.

Frequently Asked Questions

Jaydess is a levonorgestrel‑releasing intrauterine system indicated for the prevention of unintended pregnancy. It provides a highly effective, long‑acting contraceptive method when inserted into the uterus by a qualified healthcare professional.

Levonorgestrel released from the IUS binds to progesterone receptors, thickening cervical mucus, suppressing ovulation, and causing endometrial changes that inhibit fertilisation and implantation. The local hormone release ensures effective contraception with minimal systemic exposure.

The prescribed dose is determined by the prescriber. Jaydess contains a total of 13.5 mg of levonorgestrel, released at a low, steady rate over up to three years, providing continuous contraceptive protection without the need for daily dosing.

Jaydess is not intended for use during an existing pregnancy and should be removed if pregnancy occurs. Limited data exist for breastfeeding; clinicians usually weigh benefits against potential risks. Women should discuss individual circumstances with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Jaydess and other levonorgestrel IUS devices such as Mirena have similar mechanisms and efficacy. Jaydess contains 13.5 mg of levonorgestrel and is approved for up to three years of use, whereas some alternatives may have different hormone loads or approved durations, influencing choice based on patient preference and clinical guidelines.

Jaydess should be stored at room temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight and extreme temperatures to maintain its integrity until insertion by a qualified clinician.

Jaydess is inserted into the uterine cavity by a trained healthcare professional using a sterile applicator. The procedure is performed in a clinical setting, often after a brief pelvic examination and may involve local anaesthesia or analgesia for patient comfort.

Serious risks include uterine perforation during insertion, device expulsion, pelvic infection (such as pelvic inflammatory disease), and the rare possibility of ectopic pregnancy if contraceptive failure occurs. Patients should seek immediate medical attention for severe abdominal pain, abnormal bleeding or signs of infection.

Jaydess is contraindicated in women who are currently pregnant, have active pelvic infection, known or suspected uterine abnormalities (e.g., large fibroids, septate uterus), unexplained vaginal bleeding, or a known hypersensitivity to levonorgestrel or any component of the device.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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