Product image of Jaydess (Levonorgestrel) supplied by GNH India

Jaydess

Active Ingredient:
Levonorgestrel
Origin:
EU

Jaydess (Levonorgestrel)

Levonorgestrel, the active ingredient in Jaydess, is a progestin presented as a 13.5 mg intrauterine system (IUS) for intrauterine use. It provides long‑acting hormonal contraception by releasing levonorgestrel directly into the uterine cavity, preventing pregnancy in women of reproductive age.

GNH India supplies Jaydess as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution aligned to EU regulatory standards. The company ensures product quality, traceability and compliance with global pharmacovigilance requirements.

Manufacturer / TM Owner

Bayer Sa Nv

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Indications & Clinical Uses

Jaydess, a levonorgestrel‑based intrauterine system, is indicated for hormonal contraception.

  • Contraception (prevention of pregnancy): provides continuous birth control for up to three years.
  • Long‑acting reversible contraception (LARC): offers a hormone‑based method that does not require daily dosing.
  • Women desiring a low‑maintenance contraceptive: delivers levonorgestrel locally, reducing systemic exposure.

How It Works

  • Levonorgestrel released from the intrauterine system binds to progesterone receptors in the cervical mucus, endometrium and tubal epithelium. This thickens cervical mucus, impairs sperm motility and function, suppresses endometrial growth, and may inhibit ovulation, collectively preventing fertilisation and implantation.

Side Effects

Common Side Effects

  • Irregular vaginal bleeding: spotting or breakthrough bleeding, especially during the first months.
  • Amenorrhea: absence of menstrual periods after initial adjustment.
  • Pelvic or cramping pain: mild discomfort around the insertion site.
  • Breast tenderness: mild swelling or sensitivity.
  • Acne or oily skin: hormonal changes may affect skin condition.

Serious or Rare Side Effects

  • Uterine perforation: rare injury to the uterine wall during insertion.
  • Device expulsion: the IUS may be partially or fully expelled.
  • Pelvic inflammatory infection: signs include fever, foul discharge, or severe pain.
  • Ectopic pregnancy: occurs if pregnancy happens despite the device.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Hormonal side‑effects: mood changes or severe headache.

Precautions & Warnings

Before insertion, clinicians should consider several safety measures.

  • Screen for pregnancy: confirm the patient is not pregnant prior to placement.
  • Assess uterine abnormalities: evaluate for fibroids, congenital anomalies, or scarring.
  • Monitor for infection: watch for signs of pelvic infection after insertion.
  • Counsel on bleeding patterns: inform patients about possible irregular bleeding or amenorrhea.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel released from Jaydess can be affected by other medicines.

Major Interactions (Avoid)

  • Enzyme inducers (e.g., rifampin, carbamazepine): may lower levonorgestrel levels and reduce efficacy.
  • Antiretroviral drugs (e.g., efavirenz): can decrease hormonal activity.
  • St. John's wort: may reduce contraceptive effectiveness.
  • Certain anticonvulsants (e.g., phenytoin): can accelerate hormone metabolism.

Moderate Interactions (Monitor Closely)

  • Antibiotics (e.g., griseofulvin): may have a modest impact on hormone levels.
  • Herbal supplements (e.g., ginkgo biloba): monitor for any changes in bleeding.
  • Hormonal therapies (e.g., combined oral contraceptives): assess cumulative hormonal exposure.

Frequently Asked Questions

Jaydess is an intrauterine system that releases levonorgestrel to provide long‑acting reversible hormonal contraception. It is used to prevent pregnancy in women of reproductive age for up to three years after insertion.

Levonorgestrel binds to progesterone receptors, thickening cervical mucus, inhibiting sperm motility, suppressing endometrial growth, and sometimes preventing ovulation. These actions together block fertilisation and implantation, delivering effective contraception.

The dosing regimen for Jaydess is determined by the prescribing clinician. The device contains a fixed 13.5 mg of levonorgestrel and is inserted once, providing continuous contraception for up to three years.

Jaydess should not be used by women who are pregnant; it is intended for contraception before pregnancy occurs. Limited data exist for use during breastfeeding, and clinicians usually advise alternative methods until lactation is well established.

To order Jaydess, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and import documentation.

Jaydess contains 13.5 mg of levonorgestrel and is approved for up to three years of use, similar to other levonorgestrel IUDs but with a lower hormone load than some alternatives. Its efficacy, safety profile, and duration are comparable, while the smaller hormone dose may result in fewer systemic side effects for some users.

Jaydess should be stored at room temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight, and physical damage until the time of insertion.

Jaydess is inserted by a qualified healthcare professional into the uterine cavity using a sterile applicator. The procedure is performed in a clinical setting, and the device remains in place for up to three years, after which it can be removed or replaced.

Serious risks include uterine perforation during insertion, device expulsion, pelvic inflammatory infection, and the rare possibility of ectopic pregnancy if contraception fails. Patients should seek immediate medical attention for severe abdominal pain, fever, or abnormal bleeding.

Jaydess is contraindicated in women who are currently pregnant, have active pelvic infection, unexplained vaginal bleeding, known or suspected uterine anomalies, or a history of breast cancer. It should also be avoided in individuals with hypersensitivity to levonorgestrel or any component of the device.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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