Product image of Jaydess (Levonorgestrel) supplied by GNH India

Jaydess

Active Ingredient:
Levonorgestrel
Origin:
EU

Jaydess (Levonorgestrel)

Levonorgestrel, the active ingredient in Jaydess, is a progestogen presented as a 13.5 mg intrauterine system for intrauterine use. It provides continuous local release of levonorgestrel to prevent pregnancy, offering a convenient, reversible contraceptive option for women of reproductive age. The device remains effective for up to three years, reducing the need for frequent medical visits.

GNH India supplies Jaydess as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑controlled delivery of this EU‑approved contraceptive device and supporting regulatory compliance across regions.

Manufacturer / TM Owner

Bayer Ltd

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Indications & Clinical Uses

  • Jaydess, a levonorgestrel intrauterine system, is used within the contraceptive pathway to prevent unintended pregnancy.
  • Contraception (prevention of pregnancy): provides highly effective, long‑acting reversible contraception for up to three years in women of reproductive age.
  • Post‑partum contraception: offers a hormone‑based intrauterine option for women after childbirth who desire reliable birth control.
  • Breastfeeding contraception: suitable for lactating women seeking a non‑systemic method that does not affect milk production.

How It Works

  • Levonorgestrel released from the intrauterine system acts locally on the endometrium and cervical mucus. It thickens cervical mucus, creating a barrier to sperm entry, suppresses endometrial proliferation, and in many users inhibits ovulation. These combined actions prevent fertilization and implantation, maintaining contraceptive efficacy throughout the device’s lifespan.

Side Effects

Levonorgestrel intrauterine systems may be associated with a range of adverse events, which are categorized by frequency and severity.

Common Side Effects

  • Irregular vaginal bleeding or spotting
  • Amenorrhea (absence of periods)
  • Pelvic or cramping pain after insertion
  • Breast tenderness
  • Headache
  • Acne or oily skin

Serious or Rare Side Effects

  • Uterine perforation during or after insertion
  • Expulsion of the device
  • Pelvic inflammatory disease or infection
  • Ectopic pregnancy if contraception fails
  • Severe allergic reaction (anaphylaxis)
  • Deep vein thrombosis (rare)

Precautions & Warnings

  • Before prescribing Jaydess, clinicians should consider several precautionary measures to ensure patient safety.
  • Screen for contraindications: verify absence of active pelvic infection, pregnancy, or uterine anomalies.
  • Assess bleeding risk: counsel patients about possible changes in menstrual patterns.
  • Monitor for device displacement: schedule follow‑up examinations to detect expulsion or malposition.
  • Consider hormonal sensitivity: discuss potential mood changes or breast tenderness.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel released from an intrauterine system can interact with other medicines, affecting contraceptive efficacy or safety.

Major Interactions (Avoid)

  • Enzyme‑inducing anticonvulsants (e.g., carbamazepine, phenytoin): may lower levonorgestrel levels.
  • Rifampicin or other strong CYP3A4 inducers: can reduce contraceptive effectiveness.
  • Antiretroviral drugs (e.g., efavirenz): may decrease hormone exposure.
  • St John’s wort: herbal inducer that may compromise efficacy.

Moderate Interactions (Monitor Closely)

  • Antibiotics (e.g., ampicillin): unlikely to affect IUS but monitor for bleeding changes.
  • Antifungal agents (e.g., ketoconazole): may modestly increase hormone levels.
  • Hormonal therapies (e.g., estrogen patches): assess additive hormonal effects.

Frequently Asked Questions

Jaydess is an intrauterine system that delivers levonorgestrel locally to provide highly effective, long‑acting reversible contraception. It is indicated for the prevention of unintended pregnancy in women of reproductive age and can be used for up to three years after insertion.

Levonorgestrel released from the device thickens cervical mucus, creating a barrier that hinders sperm movement. It also suppresses the growth of the endometrial lining and often inhibits ovulation, together preventing fertilisation and implantation.

Jaydess contains a total of 13.5 mg of levonorgestrel, which is released at an average rate of about 20 µg per day. The exact duration and dosing schedule are determined by the prescribing clinician based on approved labeling.

Jaydess must not be used in women who are already pregnant; it is contraindicated for that condition. However, it is considered safe for breastfeeding mothers, as the hormone levels released locally are low and do not affect milk production.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Jaydess and other levonorgestrel‑based IUS devices, such as Mirena, share a similar mechanism but differ in hormone content and approved duration. Jaydess releases a lower daily dose and is approved for up to three years, whereas some alternatives may contain higher doses and be approved for longer use.

Jaydess should be stored at room temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight and extreme temperatures to maintain its integrity until the time of insertion.

Insertion of Jaydess is performed by a trained healthcare professional. The device is introduced through the cervical canal into the uterine cavity using a specialized applicator, after which the applicator is removed and the IUS remains in place to release levonorgestrel.

Serious risks, although rare, include uterine perforation during insertion, expulsion of the device, pelvic inflammatory disease, and ectopic pregnancy if contraceptive failure occurs. Prompt medical evaluation is required if severe abdominal pain, abnormal bleeding or signs of infection develop.

Jaydess is contraindicated in women who are pregnant, have active pelvic infections, unexplained vaginal bleeding, known or suspected uterine malignancy, or structural uterine abnormalities such as fibroids that distort the cavity. It should also be avoided in individuals with a history of severe allergic reaction to levonorgestrel.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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