Product image of Jazeta (Sitagliptin Hydrochloride) supplied by GNH India

Jazeta

Active Ingredient:
Sitagliptin Hydrochloride
Origin:
EU

Jazeta (Sitagliptin Hydrochloride)

Sitagliptin Hydrochloride, the active ingredient in Jazeta, is a DPP-4 inhibitor presented as an oral tablet for oral use. It is indicated for the management of type 2 diabetes mellitus in adult patients and is marketed in the European Union as a prescription-only antidiabetic agent.

GNH India supplies Jazeta as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing, regulatory support and timely delivery across multiple markets, and ensuring compliance with global quality standards.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

  • Jazeta (sitagliptin) belongs to the DPP-4 inhibitor class used to improve glycemic control in type 2 diabetes.
  • Type 2 diabetes mellitus: improves blood glucose control when used as part of a comprehensive diabetes management plan.

How It Works

  • Sitagliptin hydrochloride selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme, which degrades the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By preventing this degradation, sitagliptin increases circulating levels of GLP-1 and GIP, enhancing glucose-dependent insulin secretion from pancreatic β‑cells and suppressing glucagon release from α‑cells, thereby lowering post‑prandial and fasting plasma glucose concentrations.

Side Effects

Sitagliptin may be associated with a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Nasopharyngitis: inflammation of the nasal passages and throat.
  • Headache: mild to moderate head pain.
  • Nausea: feeling of stomach upset.

Serious or Rare Side Effects

  • Pancreatitis: severe abdominal pain possibly indicating inflammation of the pancreas.
  • Severe allergic reactions: including angioedema, rash or anaphylaxis.
  • Stevens-Johnson syndrome: life‑threatening skin reaction.

Precautions & Warnings

When prescribing Jazeta, clinicians should consider several safety factors.

  • Renal function: assess kidney function and adjust dose in moderate to severe impairment.
  • Hepatic function: use with caution in patients with severe liver disease.
  • History of pancreatitis: avoid or monitor closely for recurrence.
  • Concomitant insulin or sulfonylureas: increased risk of hypoglycemia; monitor blood glucose.
  • Pregnancy and lactation: safety not established; prescribe only if benefits outweigh risks.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Sitagliptin can interact with other medicines, requiring attention to potential changes in effect.

Major Interactions (Avoid)

  • Insulin secretagogues (e.g., sulfonylureas): may cause severe hypoglycemia.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): can increase sitagliptin plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect glycemic control; monitor blood glucose.
  • ACE inhibitors or ARBs: monitor renal function when combined.
  • Rifampin or other enzyme inducers: may reduce sitagliptin effectiveness.

Frequently Asked Questions

Jazeta contains sitagliptin hydrochloride and is prescribed to improve blood glucose control in adults with type 2 diabetes mellitus, usually as part of a broader treatment plan that includes diet, exercise and other antidiabetic agents.

Sitagliptin blocks the DPP-4 enzyme, which normally breaks down the incretin hormones GLP‑1 and GIP. Higher levels of these hormones stimulate insulin release after meals and reduce glucagon output, leading to lower blood glucose concentrations.

The dose of Jazeta is individualized by the prescribing healthcare professional based on the patient’s renal function, glycemic targets and any concomitant therapies. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of sitagliptin in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified clinician.

To request Jazeta, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Unlike sulfonylureas, which stimulate insulin regardless of glucose level, sitagliptin enhances glucose‑dependent insulin secretion, reducing the risk of hypoglycemia. Compared with metformin, it has a different mechanism and may be added when metformin alone does not achieve target glycemia.

Jazeta tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or bottle. Protect them from moisture, excessive heat and direct sunlight to maintain stability throughout the shelf‑life.

Jazeta is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless otherwise directed by a healthcare professional.

The most serious adverse events reported with sitagliptin include acute pancreatitis, severe allergic reactions such as anaphylaxis, and rare skin conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience persistent abdominal pain, rash or swelling.

Jazeta is contraindicated in patients with a known hypersensitivity to sitagliptin or any component of the formulation. It should also be avoided in individuals with a history of pancreatitis until the cause is fully evaluated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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