Product image of Jazeta (Sitagliptin Hydrochloride) supplied by GNH India

Jazeta

Active Ingredient:
Sitagliptin Hydrochloride
Origin:
EU

Jazeta (Sitagliptin Hydrochloride)

Sitagliptin Hydrochloride, the active ingredient in Jazeta, is a DPP-4 inhibitor presented as an oral tablet for oral use. It is indicated for the management of type 2 diabetes mellitus in adults when combined with diet and exercise.
GNH India supplies Jazeta as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Jazeta, a DPP‑4 inhibitor, is employed in the treatment of type 2 diabetes and related glycaemic control pathways.

  • Type 2 diabetes mellitus: lowers fasting and post‑prandial glucose levels as part of a comprehensive regimen.
  • Monotherapy in type 2 diabetes: reduces HbA1c when used alone in patients inadequately controlled by lifestyle alone.
  • Combination therapy with metformin: enhances overall glycaemic control when added to metformin‑based regimens.

How It Works

  • Sitagliptin Hydrochloride selectively inhibits the enzyme dipeptidyl peptidase‑4 (DPP‑4), preventing the breakdown of endogenous incretin hormones such as GLP‑1 and GIP. Elevated incretin levels increase glucose‑dependent insulin secretion from pancreatic β‑cells and suppress glucagon release from α‑cells, resulting in improved post‑prandial and overall blood glucose regulation.

Side Effects

Common Side Effects

  • Nasopharyngitis: mild upper respiratory tract infection symptoms.
  • Headache: transient mild to moderate head pain.
  • Upper respiratory tract infection: cough, sore throat, or congestion.
  • Gastrointestinal upset: nausea, abdominal discomfort, or diarrhoea.
  • Dizziness: occasional light‑headed sensation.

Serious or Rare Side Effects

  • Pancreatitis: severe abdominal pain requiring immediate medical attention.
  • Severe allergic reactions: rash, angioedema, or anaphylaxis.
  • Joint pain: unexplained arthralgia that may be persistent.
  • Bullous pemphigoid: rare skin blistering disorder.
  • Hepatic injury: abnormal liver function tests or jaundice.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Renal function: assess creatinine clearance and adjust dose in impaired patients.
  • Cardiovascular disease: monitor for signs of heart failure, especially in high‑risk individuals.
  • Hypersensitivity: discontinue immediately if allergic reactions occur.
  • Elderly patients: start at the lowest effective dose and titrate cautiously.
  • Pregnancy and lactation: use only if potential benefits outweigh risks.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Sitagliptin may interact with several medicines; review concomitant therapy.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase sitagliptin exposure.
  • Insulin: combined use can raise hypoglycaemia risk.
  • Sulfonylureas: heightened risk of low blood glucose.

Moderate Interactions (Monitor Closely)

  • Rifampin: may reduce sitagliptin effectiveness.
  • Diuretics: potential alteration of glucose control.
  • ACE inhibitors: monitor renal function when used together.

Frequently Asked Questions

Jazeta contains sitagliptin hydrochloride, a DPP‑4 inhibitor prescribed to improve blood glucose control in adults with type 2 diabetes mellitus, typically as part of a regimen that includes diet, exercise, and possibly other antidiabetic agents.

Sitagliptin blocks the enzyme dipeptidyl peptidase‑4, which normally degrades incretin hormones. By preserving GLP‑1 and GIP levels, it enhances insulin secretion in response to meals and reduces glucagon release, leading to lower blood glucose concentrations.

The specific dose of Jazeta is determined by the prescribing healthcare professional based on individual patient factors such as renal function, concomitant medications, and glycaemic targets. Patients should follow the prescriber’s instructions precisely.

The safety of sitagliptin during pregnancy or lactation has not been fully established. It should only be used if the potential benefit justifies the possible risk to the fetus or infant, and this decision must be made by a qualified clinician.

To place an order, submit an enquiry on the Jazeta product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with sulfonylureas, sitagliptin has a lower intrinsic risk of hypoglycaemia because its insulin‑enhancing effect is glucose‑dependent. Unlike insulin, it is an oral agent and does not require injection, offering a convenient option for patients inadequately controlled on metformin alone.

Jazeta tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and excessive heat. Keep the container tightly closed and out of direct sunlight.

Jazeta is taken orally, usually once daily, with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed.

Serious adverse events, though rare, include pancreatitis, severe allergic reactions such as anaphylaxis, and bullous pemphigoid. Patients should seek immediate medical attention if they experience persistent abdominal pain, rash, swelling, or any signs of an allergic response.

Jazeta is contraindicated in patients with a known hypersensitivity to sitagliptin or any of the tablet’s excipients. It should also be avoided in individuals with a history of pancreatitis until the cause is fully evaluated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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