Product image of Jeanine (Dienogest, Ethinylestradiol) supplied by GNH India

Jeanine

Active Ingredient:
Dienogest, Ethinylestradiol
Origin:
EU

Jeanine (Dienogest, Ethinylestradiol)

Dienogest/Ethinylestradiol, the active ingredients in Jeanine, are a combined oral contraceptive presented as a tablet for oral use. It is indicated for contraception and for regulation of menstrual cycles in women of reproductive age.

GNH India supplies Jeanine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Ag

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Indications & Clinical Uses

  • Jeanine, a combined hormonal contraceptive, acts on the reproductive endocrine system to prevent pregnancy and to normalize menstrual bleeding.
  • Contraception: prevents unintended pregnancy by inhibiting ovulation and altering cervical mucus.
  • Regulation of menstrual cycles: reduces irregular bleeding and dysmenorrhea by stabilising the endometrial lining.

How It Works

  • Dienogest and ethinylestradiol suppress the hypothalamic‑pituitary‑gonadal axis, inhibiting luteinising hormone (LH) and follicle‑stimulating hormone (FSH) release, which prevents follicular development and ovulation. The estrogen component stabilises the endometrium, while the progestogen thickens cervical mucus and further impairs implantation.

Side Effects

Jeanine may cause a range of adverse reactions. The most frequently reported events are generally mild and transient.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Breast tenderness: discomfort or swelling of the breasts.
  • Headache: occasional tension‑type headache.
  • Spotting or breakthrough bleeding: irregular light bleeding between periods.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Arterial thrombosis: clot formation in arteries leading to stroke or myocardial infarction.
  • Severe hypertension: sudden increase in blood pressure.
  • Allergic reactions: rash, swelling, or anaphylaxis.
  • Liver dysfunction: abnormal liver enzymes or jaundice.
  • Visual disturbances: sudden loss of vision or eye pain.

Precautions & Warnings

Before prescribing Jeanine, clinicians should evaluate individual risk factors and counsel patients on safe use.

  • Assess cardiovascular risk: review history of thrombosis, smoking, and hypertension.
  • Avoid smoking: especially in women over 35 years of age.
  • Review liver function: monitor hepatic enzymes in patients with liver disease.
  • Consider drug interactions: check concomitant medications that may affect hormone levels.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Jeanine can interact with several medicines that alter hormone metabolism or increase clotting risk.

Major Interactions (Avoid)

  • Enzyme‑inducing anticonvulsants (e.g., carbamazepine): may reduce contraceptive efficacy.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole): may increase hormone concentrations.
  • Hormonal breast‑cancer therapies (e.g., tamoxifen): may be contraindicated.

Moderate Interactions (Monitor Closely)

  • Rifampin and other strong antibiotics: may lower effectiveness.
  • St. John’s wort herbal supplement: may decrease plasma hormone levels.

Frequently Asked Questions

Jeanine is a prescription combined oral contraceptive that is used to prevent unintended pregnancy and to help regulate menstrual cycles. The formulation contains the progestogen dienogest and the estrogen ethinylestradiol, which together suppress ovulation and modify cervical mucus and endometrial development.

Dienogest and ethinylestradiol act on the hypothalamic‑pituitary‑gonadal axis. They inhibit the release of luteinising hormone and follicle‑stimulating hormone, preventing follicular maturation and ovulation. The estrogen component stabilises the endometrium, while the progestogen thickens cervical mucus and creates an environment that is unfavorable for sperm penetration and implantation.

The specific dosing regimen for Jeanine is determined by the prescribing clinician based on the product’s approved labeling and the patient’s individual health profile. Typically, combined oral contraceptives are taken once daily for a defined cycle, but the exact number of tablets and schedule should be confirmed by a qualified healthcare professional.

Jeanine is intended for use only when a woman is not pregnant. If pregnancy occurs, the product should be discontinued immediately. Safety data for use during breastfeeding are limited; therefore, healthcare providers usually advise against using combined oral contraceptives while nursing unless the benefits outweigh potential risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Jeanine. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Jeanine contains dienogest, a progestogen with a relatively low androgenic profile, combined with ethinylestradiol. Compared with older formulations that use levonorgestrel or norethisterone, Jeanine may offer improved cycle control and a lower risk of certain androgen‑related side effects, while maintaining comparable contraceptive efficacy.

Jeanine tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container. Protect the product from excess moisture, heat and direct sunlight to maintain potency throughout its shelf life.

Jeanine is taken orally, usually once daily at the same time each day, following the regimen indicated on the product label (e.g., 21 active tablets followed by a hormone‑free interval). Patients should swallow the tablet whole with water and should not skip doses without consulting their prescriber.

The most serious adverse events associated with combined oral contraceptives include venous thromboembolism, arterial thrombosis (stroke or myocardial infarction), severe hypertension, liver disorders and rare allergic reactions. Patients should seek immediate medical attention if they experience symptoms such as sudden chest pain, shortness of breath, severe headache, visual changes or unexplained swelling.

Jeanine is contraindicated in women with a history of thromboembolic disorders, uncontrolled hypertension, active liver disease, known or suspected breast cancer, or those who are pregnant. It should also be avoided by smokers aged 35 years or older and by individuals taking medications that markedly increase clotting risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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