Product image of Jekovit D3 (Colecalciferol) supplied by GNH India

Jekovit D3

Active Ingredient:
Colecalciferol
Origin:
EU

Jekovit D3 (Colecalciferol)

Colecalciferol, the active ingredient in Jekovit D3, is a vitamin D presented as an oral supplement for oral use. It helps correct vitamin D deficiency and supports normal calcium metabolism, contributing to bone health in individuals with limited sun exposure or dietary intake.

GNH India supplies Jekovit D3 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution through reliable logistics networks and timely delivery to meet client needs.

Manufacturer / TM Owner

Orion Corporation

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Indications & Clinical Uses

Jekovit D3 (colecalciferol) is used to address disorders of vitamin D metabolism and related bone conditions.

  • Vitamin D deficiency: restores adequate serum 25‑hydroxyvitamin D levels.
  • Osteomalacia: promotes bone mineralization to reduce softening of bones.
  • Osteoporosis prevention: assists in maintaining bone density in at‑risk populations.

How It Works

  • Colecalciferol is absorbed in the intestine and converted in the liver to 25‑hydroxyvitamin D, then in the kidney to the active hormone 1,25‑dihydroxyvitamin D. This active form binds the nuclear vitamin D receptor (VDR), up‑regulating transcription of calcium‑binding proteins and enhancing intestinal absorption of calcium and phosphate, which are essential for bone mineralization and remodeling.

Side Effects

Common Side Effects

  • Hypercalcemia: elevated blood calcium levels causing fatigue or nausea.
  • Nausea: mild gastrointestinal discomfort.
  • Headache: transient mild headache.
  • Constipation: occasional bowel movement difficulty.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Severe hypercalcemia: may lead to kidney stones or cardiac arrhythmia.
  • Allergic reaction: rash, itching, or swelling.
  • Hypercalciuria: excessive urinary calcium excretion.
  • Soft tissue calcification: deposition of calcium in organs.
  • Anaphylaxis: rare life‑threatening allergic response.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Monitor serum calcium: check levels prior to and during treatment.
  • Assess renal function: adjust use in patients with kidney impairment.
  • Avoid in hypercalcemia: contraindicated when calcium levels are already high.
  • Caution in granulomatous diseases: such as sarcoidosis, which may increase active vitamin D.
  • Pregnancy and lactation: safety not established; use only if clearly needed.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Colecalciferol may interact with several medicines.

Major Interactions (Avoid)

  • Thiazide diuretics: increase risk of hypercalcemia.
  • High‑dose vitamin A: may potentiate toxicity.
  • Calcium supplements: can cause excessive calcium levels.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (e.g., phenytoin): reduce vitamin D effectiveness.
  • Glucocorticoids: accelerate vitamin D catabolism.
  • Orlistat: decreases absorption of fat‑soluble vitamins.

Frequently Asked Questions

Jekovit D3 contains colecalciferol, a form of vitamin D, and is used to treat or prevent vitamin D deficiency, support normal bone health, and reduce the risk of osteomalacia and osteoporosis in individuals with inadequate sun exposure or dietary intake.

Colecalciferol is converted first in the liver to 25‑hydroxyvitamin D and then in the kidneys to the active hormone 1,25‑dihydroxyvitamin D. This active form binds to the vitamin D receptor, enhancing intestinal absorption of calcium and phosphate, which are essential for bone mineralization and maintenance.

The appropriate dose of Jekovit D3 is determined by a qualified healthcare professional based on the individual’s serum vitamin D level, age, weight, and clinical condition. Patients should follow the prescriber’s instructions and not self‑adjust the dosage.

Safety data for colecalciferol in pregnancy and lactation are limited. It should only be used during pregnancy or while breastfeeding if the prescriber judges that the potential benefit outweighs any possible risk to the mother or infant.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Jekovit D3 provides colecalciferol, the natural form of vitamin D3, which is generally preferred over vitamin D2 (ergocalciferol) because it has a longer half‑life and more efficiently raises serum 25‑hydroxyvitamin D levels. Its efficacy is comparable to other high‑quality vitamin D3 supplements when dosed appropriately.

Store Jekovit D3 at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Jekovit D3 is taken orally, usually with a glass of water. It can be taken with or without food, but consistent administration with meals may improve absorption of the fat‑soluble vitamin.

The most serious risk is hypercalcemia, which can cause kidney stones, cardiac arrhythmias, or calcification of soft tissues. Rarely, severe allergic reactions such as anaphylaxis may occur. Patients should report any symptoms of high calcium levels or allergic response to their healthcare provider promptly.

Individuals with known hypersensitivity to colecalciferol or any excipients, patients with existing hypercalcemia, and those with certain granulomatous diseases (e.g., sarcoidosis) should avoid using Jekovit D3 unless directed otherwise by a qualified clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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