Product image of Jenamazol (Clotrimazole) supplied by GNH India

Jenamazol

Active Ingredient:
Clotrimazole
Origin:
EU

Jenamazol (Clotrimazole)

Clotrimazole, the active ingredient in Jenamazol, is a azole antifungal presented as a tablet for vaginal use. It treats vulvovaginal candidiasis and other yeast infections in women, and is formulated for local application to relieve symptoms and eradicate the fungal organism.

GNH India supplies Jenamazol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU GMP guidelines and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Quintesence S.R.O.

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Indications & Clinical Uses

  • Jenamazol, an azole antifungal, is used to treat fungal infections of the vaginal mucosa.
  • Vulvovaginal candidiasis: reduces fungal load and alleviates itching, burning and discharge.
  • Yeast infection of the vagina: eliminates Candida species responsible for infection.
  • Recurrent vulvovaginal candidiasis: helps prevent repeated episodes when used as directed.

How It Works

  • Clotrimazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking this pathway, the drug disrupts the cell membrane integrity of Candida species, leading to impaired growth and eventual cell death. The effect is localized to the site of application, providing antifungal activity with minimal systemic absorption.

Side Effects

Clotrimazole may cause local or systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Vaginal irritation or burning
  • Itching or mild rash at the application site
  • Increased vaginal discharge

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis, facial swelling)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Liver enzyme elevation with extensive absorption

Precautions & Warnings

  • Before using Jenamazol, consider the following safety measures.
  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss safety with a physician.
  • Allergy: avoid if hypersensitivity to clotrimazole or other azoles.
  • Concurrent vaginal medication: do not use with other antifungal products without advice.
  • Duration of use: limit to the recommended period to prevent resistance.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Clotrimazole can interact with other medicines; review the following categories.

Major Interactions (Avoid)

  • Concurrent use of other azole antifungals in the vagina: may increase local irritation.
  • Systemic CYP3A4 inhibitors combined with extensive vaginal application: risk of increased systemic absorption.

Moderate Interactions (Monitor Closely)

  • Use with hormonal contraceptives: no known effect but monitor for irritation.
  • Co‑administration with spermicides or lubricants: may alter drug efficacy.
  • Topical steroids applied nearby: may reduce antifungal activity.

Frequently Asked Questions

Jenamazol is an over‑the‑counter vaginal tablet containing clotrimazole, used to treat vulvovaginal candidiasis and other yeast infections of the vagina. It works by eliminating the Candida fungi that cause itching, burning, and abnormal discharge, providing symptom relief and infection clearance.

Clotrimazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for producing ergosterol, a key component of fungal cell membranes. Without ergosterol, the cell membrane becomes defective, leading to inhibited growth and death of the Candida organisms at the site of application.

The exact dosing regimen for Jenamazol is determined by the prescribing healthcare professional. Typically, a single vaginal tablet is inserted and left in place for a period ranging from three to seven days, but the prescriber will set the precise schedule based on the individual’s condition.

Safety data for clotrimazole in pregnancy are limited, so it should be used only if clearly needed and after consulting a healthcare provider. During breastfeeding, the drug is minimally absorbed systemically, but a physician should be consulted to weigh any potential risks to the infant.

To order Jenamazol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Jenamazol (clotrimazole) belongs to the azole class of antifungals, offering a broad spectrum against Candida species. Compared with polyene agents such as nystatin, azoles generally have better tissue penetration and a more convenient dosing schedule, while maintaining a favorable safety profile for short‑term vaginal use.

Store Jenamazol at room temperature, ideally below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to extreme heat or humidity, which could affect tablet integrity.

Jenamazol is administered as a vaginal tablet. The tablet is inserted into the vagina using an applicator or clean fingers, allowing it to dissolve and release clotrimazole locally. Follow the prescriber’s instructions regarding timing, frequency and duration of treatment.

While most reactions are mild, serious risks include severe allergic responses such as anaphylaxis, skin reactions like Stevens‑Johnson syndrome, and rare liver enzyme elevations if significant systemic absorption occurs. Seek immediate medical attention if you experience swelling, difficulty breathing, rash spreading beyond the vagina, or persistent jaundice.

Individuals with a known hypersensitivity to clotrimazole, other azole antifungals, or any component of the tablet should avoid using Jenamazol. It is also not recommended for women who are pregnant or breastfeeding without medical advice, and for those currently using other vaginal antifungal products unless directed by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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