Product image of Jenamazol (Clotrimazole) supplied by GNH India

Jenamazol

Active Ingredient:
Clotrimazole
Origin:
EU

Jenamazol (Clotrimazole)

Clotrimazole, the active ingredient in Jenamazol, is an imidazole antifungal presented as a vaginal formulation for vaginal use. It treats vulvovaginal candidiasis, a common yeast infection affecting women.

GNH India supplies Jenamazol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Quintesence S.R.O.

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Indications & Clinical Uses

Jenamazol, an imidazole antifungal, is used to manage Candida infections affecting various mucosal and skin sites.

  • Vulvovaginal candidiasis: relieves symptoms and eradicates Candida overgrowth in the vagina.
  • Cutaneous candidiasis: treats superficial skin infections caused by Candida species.
  • Oropharyngeal candidiasis: helps clear yeast infection of the mouth and throat.

How It Works

  • Clotrimazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking this pathway, the drug disrupts cell membrane formation, leading to increased membrane permeability and ultimately fungal cell death.

Side Effects

Common Side Effects

  • Local irritation: burning or stinging at the site of application.
  • Itching: mild pruritus in the vaginal area.
  • Discharge: increased vaginal secretions.
  • Dryness: sensation of dryness or tightness.
  • Redness: mild erythema around the application site.
  • Odor change: temporary alteration of vaginal odor.

Serious or Rare Side Effects

  • Allergic reaction: hives, swelling, or difficulty breathing.
  • Severe skin rash: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Liver toxicity: rare signs of hepatitis such as jaundice.
  • Systemic hypersensitivity: fever, chills, or malaise.
  • Persistent vaginal ulceration.
  • Unexplained bleeding or severe irritation.

Precautions & Warnings

Before using Jenamazol, consider the following safety measures.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Allergy: avoid if known hypersensitivity to clotrimazole or other imidazoles.
  • Concurrent vaginal products: do not use with other intravaginal medications unless directed.
  • Immunocompromised patients: monitor closely for treatment failure.
  • Store at room temperature: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Clotrimazole may interact with other medicines; review the following categories.

Major Interactions (Avoid)

  • Systemic azole antifungals: increased risk of additive toxicity.
  • Warfarin: potential enhancement of anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: possible reduction in hormonal efficacy.
  • Topical steroids: may diminish antifungal activity.
  • Antacids: could affect absorption of concurrently administered oral agents.
  • Other intravaginal medications: may alter local drug concentration.

Frequently Asked Questions

Jenamazol contains clotrimazole and is used to treat vulvovaginal candidiasis, a yeast infection of the vagina. It may also be employed for other Candida infections such as skin or oral thrush, depending on the formulation and physician recommendation.

Clotrimazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for producing ergosterol, a key component of the fungal cell membrane. This inhibition disrupts membrane integrity, leading to fungal cell death and resolution of the infection.

The specific dosing regimen for Jenamazol is determined by the prescribing healthcare professional based on the infection severity, patient characteristics, and local guidelines. Patients should follow the exact instructions provided by their prescriber.

Safety data for clotrimazole in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Jenamazol.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Clotrimazole is an imidazole antifungal with a broad spectrum against Candida species. Compared with azole agents like fluconazole, clotrimazole is typically applied locally, offering high concentrations at the infection site with minimal systemic exposure, which can reduce systemic side‑effects.

Store Jenamazol at room temperature, below 25 °C, in its original packaging. Keep it away from moisture, direct sunlight, and excessive heat to maintain product stability and efficacy.

Jenamazol is intended for vaginal use. The prescribed tablet or suppository is inserted into the vagina according to the prescriber’s instructions, usually once daily for a specified number of days, and should not be used orally or intravenously.

Serious adverse reactions, although rare, include severe allergic responses such as anaphylaxis, Stevens‑Johnson syndrome, toxic epidermal necrolysis, and significant liver toxicity. Patients should seek immediate medical attention if they experience symptoms like difficulty breathing, widespread rash, or jaundice.

Individuals with a known hypersensitivity to clotrimazole, other imidazole antifungals, or any component of the formulation should avoid using Jenamazol. Additionally, patients with severe liver disease or those taking interacting medications listed under major interactions should consult their clinician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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