Product image of Jidinum (Sitagliptin) supplied by GNH India

Jidinum

Active Ingredient:
Sitagliptin
Origin:
EU

Jidinum (Sitagliptin)

Sitagliptin, the active ingredient in Jidinum, is a Dipeptidyl peptidase‑4 (DPP‑4) inhibitor presented as an oral dosage form for oral use. It is indicated for the management of type 2 diabetes mellitus in adult patients, helping to improve glycaemic control when combined with diet and exercise.

GNH India supplies Jidinum as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution through its experienced network of partners.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

Sitagliptin is used to improve glycaemic control in patients with type 2 diabetes mellitus.

  • Type 2 diabetes mellitus: lowers fasting and post‑prandial blood glucose when added to diet and exercise.
  • Inadequate control with metformin alone: provides additional glucose lowering as adjunct therapy.
  • Metformin intolerance: serves as an alternative oral antidiabetic option.
  • Combination with sulfonylureas: enhances overall glycaemic reduction while monitoring hypoglycaemia risk.
  • Use in elderly patients: offers glucose control with low risk of hypoglycaemia.

How It Works

  • Sitagliptin selectively inhibits the enzyme dipeptidyl peptidase‑4 (DPP‑4), which degrades the incretin hormones glucagon‑like peptide‑1 (GLP‑1) and glucose‑dependent insulinotropic polypeptide (GIP). By blocking DPP‑4, sitagliptin raises circulating GLP‑1 and GIP levels, enhancing glucose‑dependent insulin secretion from pancreatic β‑cells and suppressing glucagon release from α‑cells, thereby reducing blood glucose concentrations.

Side Effects

Sitagliptin may be associated with several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Nausea
  • Headache
  • Upper respiratory tract infection
  • Diarrhoea

Serious or Rare Side Effects

  • Pancreatitis
  • Severe allergic reactions (e.g., angioedema, anaphylaxis)
  • Bullous pemphigoid

Precautions & Warnings

When prescribing sitagliptin, clinicians should consider several safety precautions.

  • Renal function: assess baseline renal function and adjust use in patients with severe impairment.
  • Hepatic impairment: use with caution in patients with liver disease; monitor liver enzymes.
  • Hypersensitivity: discontinue immediately if signs of allergic reaction such as rash or swelling appear.
  • Cardiovascular disease: monitor patients with a history of heart failure for any worsening symptoms.
  • Pregnancy and lactation: safety not established; avoid unless potential benefits justify the risk.
  • Store at ambient temperature: keep tablets in the original container, protect from moisture and light.

Avoid Interactions

Sitagliptin can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Insulin: combined use may increase risk of hypoglycaemia.
  • Sulfonylureas: concurrent therapy can potentiate hypoglycaemic events.

Moderate Interactions (Monitor Closely)

  • Rifampin: enzyme induction may reduce sitagliptin plasma concentrations.
  • Diuretics: may alter glucose control; monitor blood sugar.
  • ACE inhibitors: observe renal function when used together.

Frequently Asked Questions

Jidinum contains sitagliptin, which is prescribed to improve blood glucose control in adults with type 2 diabetes mellitus. It is used as part of a comprehensive treatment plan that includes diet, exercise, and, when needed, other antidiabetic agents.

Sitagliptin works by selectively inhibiting the enzyme dipeptidyl peptidase‑4 (DPP‑4). This inhibition raises levels of the incretin hormones GLP‑1 and GIP, which increase insulin secretion and reduce glucagon release in a glucose‑dependent manner, helping to lower blood sugar.

The appropriate dose of Jidinum is determined by the prescribing healthcare professional based on the individual’s clinical condition, renal function, and response to therapy. Patients should follow the dosage instructions provided by their prescriber and pharmacist.

Safety of sitagliptin in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Jidinum, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Jidinum (sitagliptin) belongs to the DPP‑4 inhibitor class, offering glucose‑dependent insulin release with a low risk of hypoglycaemia compared with sulfonylureas. Unlike insulin, it is taken orally and does not require injection, making it a convenient option for many patients.

Store Jidinum tablets at ambient temperature, below 25 °C, in the original packaging. Protect them from moisture, direct sunlight and excessive heat. Keep the product out of reach of children and do not use after the expiry date.

Jidinum is taken orally, usually once daily, with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

The most serious adverse events reported with sitagliptin include pancreatitis, severe allergic reactions such as angioedema or anaphylaxis, and rare skin conditions like bullous pemphigoid. Patients should seek immediate medical attention if they experience severe abdominal pain, rash, or swelling.

Jidinum should be avoided in patients with a known hypersensitivity to sitagliptin or any component of the formulation. Caution is also advised for individuals with severe renal impairment, active pancreatitis, or those for whom the benefits of therapy do not outweigh potential risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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