Product image of Jidinum (Sitagliptin) supplied by GNH India

Jidinum

Active Ingredient:
Sitagliptin
Origin:
EU

Jidinum (Sitagliptin)

Sitagliptin, the active ingredient in Jidinum, is a dipeptidyl peptidase-4 (DPP‑4) inhibitor presented as a tablet for oral use. It treats type 2 diabetes mellitus in adult patients by improving blood glucose control.

GNH India supplies Jidinum as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

Sitagliptin is used in the management of type 2 diabetes mellitus, either alone or in combination with other antidiabetic agents.

  • Type 2 diabetes mellitus (monotherapy): improves glycemic control by enhancing insulin secretion and reducing glucagon release.
  • Type 2 diabetes mellitus (combined with metformin): provides additional glucose lowering when metformin alone is insufficient.
  • Type 2 diabetes mellitus (combined with insulin): helps achieve target HbA1c while allowing lower insulin doses.

How It Works

  • Sitagliptin selectively inhibits the dipeptidyl peptidase‑4 (DPP‑4) enzyme, which degrades the incretin hormones GLP‑1 and GIP. By preventing this degradation, endogenous GLP‑1 and GIP levels rise, leading to glucose‑dependent stimulation of insulin secretion, suppression of glucagon release, and ultimately lower post‑prandial and fasting blood glucose concentrations.

Side Effects

Sitagliptin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nasopharyngitis: mild upper respiratory tract infection symptoms.
  • Headache: transient mild to moderate pain.
  • Upper respiratory infection: cough, sore throat, or congestion.
  • Nausea: occasional mild gastrointestinal discomfort.
  • Diarrhea: loose stools that resolve spontaneously.
  • Arthralgia: joint pain without swelling.

Serious or Rare Side Effects

  • Pancreatitis: severe abdominal pain requiring immediate medical attention.
  • Severe allergic reactions: rash, angioedema, or anaphylaxis.
  • Bullous pemphigoid: blistering skin disorder.
  • Hepatic injury: elevated liver enzymes or hepatitis.
  • Joint inflammation: severe or persistent joint swelling.
  • Hypoglycemia: especially when combined with insulin or sulfonylureas.

Precautions & Warnings

When prescribing or dispensing sitagliptin, consider the following safety measures.

  • Renal impairment: assess kidney function and adjust dose if necessary.
  • Hepatic impairment: use with caution in patients with liver disease.
  • History of pancreatitis: avoid use due to risk of recurrence.
  • Elderly patients: monitor for hypoglycemia when used with insulin secretagogues.
  • Concomitant medications: review for potential drug interactions.
  • Store at ambient temperature below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Sitagliptin can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase sitagliptin exposure.
  • Insulin secretagogues (e.g., sulfonylureas): heightened risk of hypoglycemia.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect renal clearance of sitagliptin.
  • ACE inhibitors: monitor renal function and electrolytes.
  • Warfarin: observe INR for potential changes.
  • Rifampin: may reduce sitagliptin plasma levels.
  • Digoxin: monitor for altered digoxin concentrations.

Frequently Asked Questions

Jidinum contains sitagliptin, a DPP‑4 inhibitor indicated for the treatment of type 2 diabetes mellitus in adults. It helps lower blood glucose by increasing insulin release and decreasing glucagon when meals are consumed.

Sitagliptin blocks the DPP‑4 enzyme, which normally breaks down the incretin hormones GLP‑1 and GIP. Higher levels of these hormones enhance glucose‑dependent insulin secretion and suppress glucagon, resulting in improved glycemic control.

The dose of Jidinum is determined by the prescribing clinician based on the patient’s clinical condition, renal function, and any concomitant antidiabetic therapy. No fixed regimen is provided here.

The safety of sitagliptin in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To place an order, submit an enquiry on the Jidinum product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Compared with sulfonylureas, sitagliptin has a lower risk of hypoglycemia when used alone because its action is glucose‑dependent. Unlike metformin, it does not affect gastrointestinal absorption and can be combined with many other agents for additive glucose‑lowering effects.

Jidinum tablets should be stored at ambient temperature below 25 °C, in the original container, protected from moisture and direct sunlight. Do not store in a refrigerator or freezer.

Jidinum is taken orally, usually once daily, with or without food, as directed by the prescribing healthcare professional.

Serious adverse events include pancreatitis, severe allergic reactions such as anaphylaxis, bullous pemphigoid, and hepatic injury. Prompt medical evaluation is required if any of these symptoms occur.

Patients with a known hypersensitivity to sitagliptin or any component of the formulation, those with a history of pancreatitis, or individuals with severe renal impairment (eGFR < 30 mL/min/1.73 m²) should avoid using Jidinum.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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