Product image of Jinarc (Tolvaptan) supplied by GNH India

Jinarc

Active Ingredient:
Tolvaptan
Origin:
EU

Jinarc (Tolvaptan)

Tolvaptan, the active ingredient in Jinarc, is a vasopressin V2 receptor antagonist presented as an oral formulation for oral use. It is indicated for the treatment of hyponatremia associated with euvolemic or hypervolemic states and for slowing disease progression in autosomal dominant polycystic kidney disease.

GNH India supplies Jinarc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company follows stringent quality standards and provides reliable logistics for global distribution. This includes temperature‑controlled shipping where required to maintain product integrity.

Manufacturer / TM Owner

Otsuka Pharmaceutical Netherlands B.V.

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Indications & Clinical Uses

Jinarc (tolvaptan) acts on the vasopressin V2 receptor pathway to manage disorders of water balance and cystic kidney disease.

  • Hyponatremia (euvolemic or hypervolemic): helps raise serum sodium by promoting free water excretion.
  • Hyponatremia in heart failure: reduces fluid overload while correcting sodium levels.
  • Autosomal dominant polycystic kidney disease (ADPKD): slows cyst growth and preserves renal function.

How It Works

  • Tolvaptan selectively blocks the vasopressin V2 receptors located in the renal collecting ducts, inhibiting the action of antidiuretic hormone. This blockade prevents water reabsorption, leading to increased free water excretion (aquaresis) without significant loss of electrolytes, thereby correcting serum sodium abnormalities and reducing cystic fluid accumulation in the kidneys.

Side Effects

Common Side Effects

  • Thirst
  • Polyuria (increased urine output)
  • Dry mouth
  • Elevated serum sodium
  • Mild elevation of liver enzymes
  • Constipation

Serious or Rare Side Effects

  • Severe hypernatremia
  • Hepatic injury or hepatitis
  • Dehydration leading to hypotension
  • Allergic reactions such as rash or angioedema

Precautions & Warnings

Before initiating therapy, clinicians should assess patient suitability and monitor key parameters.

  • Monitor serum sodium: avoid rapid correction to prevent osmotic demyelination.
  • Assess liver function: regular ALT/AST testing is recommended.
  • Evaluate renal function: use cautiously in patients with impaired kidney function.
  • Avoid use in hypovolemic patients: ensure adequate fluid status before treatment.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Tolvaptan may interact with other medicines that affect its metabolism or fluid balance.

Major Interactions (Avoid)

  • Strong CYP3A inhibitors (e.g., ketoconazole, clarithromycin): increase tolvaptan exposure.
  • Strong CYP3A inducers (e.g., rifampin, carbamazepine): reduce therapeutic effect.
  • Concurrent V2 receptor antagonists (e.g., conivaptan): may cause additive aquaresis.

Moderate Interactions (Monitor Closely)

  • Diuretics: heightened risk of dehydration and electrolyte disturbances.
  • NSAIDs: may impair renal function when combined.
  • Lithium: increased risk of lithium toxicity.
  • ACE inhibitors or ARBs: monitor potassium and renal parameters.

Frequently Asked Questions

Jinarc is prescribed to treat hyponatremia that occurs in euvolemic or hypervolemic conditions, such as syndrome of inappropriate antidiuretic hormone secretion, and to slow disease progression in patients with autosomal dominant polycystic kidney disease.

Tolvaptan selectively blocks vasopressin V2 receptors in the kidney collecting ducts. By inhibiting the antidiuretic hormone’s action, it reduces water reabsorption, leading to increased free water excretion (aquaresis) while preserving electrolyte balance.

The dose of Jinarc is individualized by the prescribing clinician based on the patient’s condition, laboratory values, and response to therapy. Specific dosing regimens are not provided here and should follow the prescriber’s instructions.

Safety data for Tolvaptan in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any potential risk to the fetus or infant, and decisions should be made in consultation with a healthcare professional.

To request Jinarc, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike traditional diuretics, Tolvaptan specifically antagonizes the V2 receptor, promoting water loss without significant electrolyte loss. This mechanism can correct sodium levels more directly than fluid restriction or saline infusion, but it requires careful monitoring for rapid sodium shifts.

Store Jinarc at temperatures below 25 °C, in its original packaging, and protect it from moisture. Do not expose the product to excessive heat or humidity, and keep it out of reach of children.

Jinarc is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious risks include severe hypernatremia, significant liver injury, dehydration leading to hypotension, and rare allergic reactions. Patients should be monitored regularly for serum sodium, liver enzymes and signs of fluid imbalance.

Jinarc should be avoided in patients with uncontrolled hypovolemia, active severe liver disease, or known hypersensitivity to Tolvaptan. It is also contraindicated in individuals taking other V2 receptor antagonists without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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