Product image of Jivi (Damoctocog Alfa Pegol) supplied by GNH India

Jivi

Active Ingredient:
Damoctocog Alfa Pegol
Origin:
EU

Jivi (Damoctocog Alfa Pegol)

Damoctocog alfa pegol, the active ingredient in Jivi, is a recombinant factor VIII product presented as a solution for injection for intravenous use. It replaces the deficient clotting factor in patients with hemophilia A, helping to control and prevent bleeding episodes.

GNH India supplies Jivi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Ag

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Indications & Clinical Uses

  • Jivi is a recombinant factor VIII therapy used within the hemophilia A treatment pathway.
  • Prophylaxis: reduces the frequency of spontaneous bleeding episodes in patients with hemophilia A.
  • Acute Bleeding Treatment: controls and stops active bleeding episodes in hemophilia A patients.
  • Surgical Coverage: provides hemostatic support during surgical procedures for individuals with hemophilia A.

How It Works

  • Damoctocog alfa pegol supplies functional factor VIII, restoring the deficient clotting factor in hemophilia A. By reconstituting the intrinsic coagulation cascade, it enables the generation of thrombin and formation of a stable fibrin clot, thereby correcting the bleeding tendency associated with factor VIII deficiency.

Side Effects

Jivi may be associated with several adverse reactions.

Common Side Effects

  • Injection site pain or erythema
  • Headache
  • Fever or chills
  • Arthralgia
  • Nausea
  • Fatigue

Serious or Rare Side Effects

  • Development of inhibitory antibodies against factor VIII
  • Anaphylactic or severe hypersensitivity reactions
  • Thromboembolic events
  • Severe hemolysis
  • Disseminated intravascular coagulation (DIC)

Precautions & Warnings

When using Jivi, certain precautions should be observed.

  • Individualized Dosing: dosing must be determined by a qualified prescriber based on patient-specific factors.
  • Inhibitor Monitoring: regularly assess for development of factor VIII inhibitors.
  • Hypersensitivity: avoid in patients with known allergy to the product or its excipients.
  • Concomitant Anticoagulants: use caution if the patient is receiving other anticoagulant therapies.
  • Renal/Hepatic Function: evaluate organ function before initiating therapy.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the vial.

Avoid Interactions

Jivi can interact with other medicines, requiring attention to potential effects.

Major Interactions (Avoid)

  • Concurrent use with other factor VIII concentrates may increase inhibitor risk.
  • Simultaneous administration with high‑dose anticoagulants can compromise hemostasis.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., aminoglycosides) may interfere with clotting assays.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs) may elevate bleeding tendency.
  • Immunosuppressive agents could affect inhibitor development monitoring.

Frequently Asked Questions

Jivi is used as a replacement therapy for patients with hemophilia A. It provides the missing factor VIII to help prevent and control bleeding episodes, both in routine prophylaxis and during acute bleeding events.

Damoctocog alfa pegol supplies functional factor VIII, which restores the intrinsic pathway of the coagulation cascade. This enables proper thrombin generation and fibrin clot formation, correcting the clotting deficiency seen in hemophilia A.

The dose of Jivi is individualized and must be prescribed by a qualified healthcare professional. The prescriber determines the amount and frequency based on the patient’s weight, severity of hemophilia, and clinical situation.

The safety of Jivi in pregnancy and lactation has not been fully established. Use should be considered only if the potential benefit justifies any potential risk to the mother or infant, and decisions are made by the treating physician.

To order Jivi, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and import documentation.

Jivi is a PEGylated recombinant factor VIII, offering an extended half‑life compared with standard factor VIII concentrates. This allows less frequent dosing for prophylaxis while maintaining comparable efficacy and safety profiles.

Jivi must be stored refrigerated at 2‑8 °C, protected from light. Do not freeze or shake the vial. If the product must be transported, maintain the cold chain using validated insulated containers.

Jivi is given as an intravenous infusion. The solution for injection is administered by a healthcare professional using aseptic technique, typically through a peripheral or central venous line, according to the prescriber’s instructions.

The most serious risks include the development of inhibitory antibodies against factor VIII, which can reduce efficacy, and rare severe hypersensitivity reactions such as anaphylaxis. Monitoring for these events is essential during treatment.

Jivi should not be used in patients with known hypersensitivity to damoctocog alfa pegol or any of its excipients. It is also contraindicated in individuals who have previously developed severe allergic reactions to factor VIII products.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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