Product image of Johanniskraut Sidroga (Hypericum Perforatum) supplied by GNH India

Johanniskraut Sidroga

Active Ingredient:
Hypericum Perforatum
Origin:
EU

Johanniskraut Sidroga (Hypericum Perforatum)

Hypericum perforatum, the active ingredient in Johanniskraut Sidroga, is a herbal extract presented as an oral preparation for oral use. It is traditionally employed to support mild to moderate mood disturbances and seasonal affective symptoms in adult patients. It is available as a standardized extract containing hypericin and hyperforin, the constituents thought to contribute to its activity.

GNH India supplies Johanniskraut Sidroga as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support international distribution.

Manufacturer / TM Owner

Uriach Germany Gmbh

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Indications & Clinical Uses

Johanniskraut Sidroga is used primarily for mood‑related conditions and related affective disorders. Clinical observations suggest benefit in several affective and stress‑related conditions.

  • Mild to moderate depression: may help improve mood and alleviate depressive symptoms.
  • Seasonal affective disorder: supports mood stabilization during seasonal changes.
  • Minor anxiety: may reduce feelings of nervousness and improve emotional well‑being.
  • Sleep disturbances: may aid in improving sleep quality associated with mood disorders.
  • Stress‑related fatigue: may help alleviate fatigue linked to chronic stress.

How It Works

  • Hypericum perforatum contains the phytochemicals hypericin and hyperforin, which influence several neurotransmitter systems. The extract inhibits the re‑uptake of serotonin, norepinephrine and dopamine, thereby increasing their synaptic availability. It also modulates the hypothalamic‑pituitary‑adrenal axis and exhibits anti‑inflammatory and antioxidant activity, contributing to its mood‑stabilising effects. Additionally, it may affect ion channel function and reduce cortisol release, further supporting emotional balance.

Side Effects

Adverse reactions to Johanniskraut Sidroga are reported with varying frequency and severity.

Common Side Effects

  • Photosensitivity: increased sensitivity to sunlight, leading to sunburn‑like reactions.
  • Gastrointestinal upset: nausea, abdominal discomfort, or diarrhoea.
  • Dizziness: transient light‑headedness or balance disturbances.
  • Fatigue: feeling unusually tired or weak.

Serious or Rare Side Effects

  • Serotonin syndrome: potentially life‑threatening condition with agitation, hyperthermia, and muscle rigidity.
  • Severe allergic reaction: rash, swelling, or anaphylaxis requiring immediate medical attention.
  • Liver enzyme elevation: abnormal liver function tests indicating possible hepatic stress.

Precautions & Warnings

When considering Johanniskraut Sidroga, several safety measures and warnings should be observed.

  • Pregnancy: safety not established; avoid unless prescribed by a qualified healthcare professional.
  • Breastfeeding: insufficient data; discuss risks with a medical provider before use.
  • Photosensitivity: limit sun exposure and use protective clothing or sunscreen.
  • Drug interactions: review all concomitant medications, especially serotonergic agents, before initiating therapy.
  • Medical conditions: use with caution in patients with bipolar disorder or a history of mania.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Johanniskraut Sidroga can affect the pharmacokinetics or pharmacodynamics of several medicines; awareness of these interactions is essential.

Major Interactions (Avoid)

  • SSRIs (e.g., sertraline, fluoxetine): combined use may precipitate serotonin syndrome.
  • MAO inhibitors: concurrent administration can lead to hypertensive crises and serotonin excess.
  • Oral contraceptives: hypericum may lower plasma concentrations, reducing contraceptive effectiveness.

Moderate Interactions (Monitor Closely)

  • Warfarin: hypericum can enhance anticoagulant effect; monitor INR closely.
  • Cyclosporine: may decrease cyclosporine levels; therapeutic drug monitoring is recommended.

Frequently Asked Questions

Johanniskraut Sidroga is an oral herbal product containing Hypericum perforatum. It is commonly used to support mild to moderate depressive symptoms, seasonal affective disorder, minor anxiety, sleep disturbances related to mood, and fatigue associated with chronic stress. The preparation is intended for adult patients under medical supervision.

The active plant compounds, primarily hypericin and hyperforin, act on several neurotransmitter pathways. They inhibit the re‑uptake of serotonin, norepinephrine and dopamine, increasing the levels of these mood‑regulating chemicals in the brain. Additional anti‑inflammatory and antioxidant actions, as well as modulation of the hypothalamic‑pituitary‑adrenal axis, may contribute to its overall effect on emotional balance.

The appropriate dosage of Johanniskraut Sidroga is determined by the prescribing healthcare professional based on the individual’s condition, age, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose without medical advice.

Safety data for Hypericum perforatum during pregnancy and lactation are limited. It is generally advised to avoid use unless the potential benefit outweighs the risk and it is prescribed by a qualified clinician. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Unlike synthetic antidepressants such as selective serotonin re‑uptake inhibitors (SSRIs), Johanniskraut Sidroga is a botanical extract that influences multiple neurotransmitter systems simultaneously. It may have a milder side‑effect profile for some patients but carries a higher potential for drug‑drug interactions, especially with serotonergic agents. Clinical effectiveness varies, and choice of therapy should be individualized.

The product should be stored at ambient temperature, ideally below 25 °C. Keep the container tightly closed, protect it from moisture and direct sunlight, and retain it in the original packaging until use. Do not store in a refrigerator or freezer unless the label specifically indicates otherwise.

Johanniskraut Sidroga is taken orally, usually with water. The exact administration schedule—such as taking it with or without food—should follow the prescribing clinician’s guidance. Swallow tablets or capsules whole; do not crush or chew unless directed.

Serious adverse events include serotonin syndrome when combined with other serotonergic drugs, severe allergic reactions (including anaphylaxis), and potential liver enzyme elevations indicating hepatic stress. Patients should seek immediate medical attention if they experience symptoms such as rapid heart rate, high fever, agitation, rash, swelling, or jaundice.

Individuals taking monoamine oxidase inhibitors, SSRIs, other serotonergic medications, oral contraceptives, anticoagulants like warfarin, or those with a history of bipolar disorder or mania should avoid or use the product only under strict medical supervision. Pregnant or breastfeeding women should also consult their healthcare provider before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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