Johanniskraut-Trockenextrakt Madaus (St. John's Wort Dry Extract (3.5-6.0:1), Extraction Solvent: Ethanol 60% (M/M))

The extract contains compounds such as hypericin and hyperforin that are believed to inhibit the reuptake of serotonin, dopamine and norepinephrine, and to modestly block monoamine oxidase activity. These actions increase the availability of mood‑regulating neurotransmitters in the brain, contributing to its antidepressant effect.

The appropriate dose is determined by a qualified healthcare professional based on the individual’s condition, age, and concomitant medications. Prescribers follow local guidelines and may adjust the amount according to therapeutic response and tolerability.

Safety data for St. John's Wort during pregnancy and lactation are limited. Healthcare providers generally advise against routine use in pregnant or nursing women unless the potential benefits outweigh the risks and the product is prescribed with close monitoring.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with synthetic antidepressants, St. John's Wort is a botanical option with a different side‑effect profile. It may have fewer sexual dysfunction issues but carries a higher risk of drug‑drug interactions, especially with serotonergic agents, and can cause photosensitivity. Clinical efficacy is generally considered comparable for mild to moderate depression.

The product should be stored at ambient temperature, below 25 °C, in its original packaging. Protect it from moisture and direct sunlight to maintain stability. Keep out of reach of children.

It is taken orally, typically as a capsule or tablet, according to the dosage prescribed by a healthcare professional. The product should be swallowed with water and taken with or without food as directed.

The most serious concerns include the potential for serotonin syndrome when combined with other serotonergic drugs, severe photosensitivity reactions, and rare cases of liver enzyme elevation or allergic reactions. Patients should be monitored for these events, especially when using interacting medications.

Individuals taking monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, other serotonergic agents, oral contraceptives, anticoagulants, or those with a history of bipolar disorder, severe liver disease, or hypersensitivity to Hypericum species should avoid using this product unless closely supervised by a clinician.