Product image of Jokath (Timolol, Travoprost) supplied by GNH India

Jokath

Active Ingredient:
Timolol, Travoprost
Origin:
EU

Jokath (Timolol, Travoprost)

Timolol and Travoprost, the active ingredients in Jokath, are a beta‑blocker and a prostaglandin analog presented as ocular eye drops for ophthalmic use. They are prescribed to lower intra‑ocular pressure in patients with certain types of glaucoma and ocular hypertension.

GNH India supplies Jokath as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmathen S.A.

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Indications & Clinical Uses

  • Jokath is used in the management of ocular conditions that require reduction of intra‑ocular pressure.
  • Open‑angle glaucoma: lowers intra‑ocular pressure to slow disease progression.
  • Ocular hypertension: reduces pressure to prevent development of glaucoma.

How It Works

  • Timolol acts as a non‑selective β‑adrenergic antagonist, decreasing aqueous humor production by blocking β‑receptors in the ciliary body. Travoprost, a prostaglandin F2α analog, increases uveoscleral outflow of aqueous humor by remodeling extracellular matrix in the eye, together resulting in lowered intra‑ocular pressure.

Side Effects

Jokath may cause a range of ocular and systemic reactions.

Common Side Effects

  • Eye irritation or burning sensation
  • Blurred vision
  • Dry eye or foreign body sensation
  • Redness of the conjunctiva
  • Increased eyelash growth or pigmentation changes
  • Mild headache

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angio‑edema, anaphylaxis)
  • Significant eye pain or sudden loss of vision
  • Systemic beta‑blocker effects such as bradycardia, hypotension, or bronchospasm
  • Uveitis or intra‑ocular inflammation

Precautions & Warnings

  • Before initiating Jokath, clinicians should consider several safety aspects.
  • Cardiovascular assessment: patients with bradycardia, heart block, or severe asthma may be at increased risk.
  • Respiratory status: avoid in patients prone to bronchospasm due to systemic β‑blockade.
  • Allergy screening: do not use in individuals with known hypersensitivity to beta‑blockers or prostaglandin analogs.
  • Concurrent ocular hypotensives: monitor intra‑ocular pressure when used with other pressure‑lowering agents.
  • Pregnancy and lactation: prescribe only if the potential benefit justifies the potential risk.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Jokath can interact with other medications, requiring careful management.

Major Interactions (Avoid)

  • Systemic non‑selective beta‑blockers (e.g., propranolol): may cause additive bradycardia or hypotension.
  • Inhaled β2‑agonists or corticosteroids for asthma: increased risk of bronchospasm.
  • Other prostaglandin analog eye drops: may amplify ocular side effects.

Moderate Interactions (Monitor Closely)

  • Topical ocular anesthetics: may enhance corneal irritation.
  • Combination therapy with carbonic anhydrase inhibitors: monitor intra‑ocular pressure for excessive reduction.
  • CYP2C9 inhibitors (e.g., fluconazole): may increase travoprost exposure, watch for heightened side effects.

Frequently Asked Questions

Jokath is a prescription ophthalmic eye drop that combines timolol and travoprost to lower intra‑ocular pressure. It is indicated for the treatment of open‑angle glaucoma and ocular hypertension, helping to prevent optic nerve damage and preserve visual function.

Timolol reduces the production of aqueous humor by blocking β‑adrenergic receptors in the ciliary body, while travoprost increases uveoscleral outflow of aqueous humor as a prostaglandin F2α analog. Together they achieve a complementary reduction in intra‑ocular pressure.

The dosing regimen for Jokath is determined by the prescribing clinician based on the patient’s condition, response, and tolerance. Typically, one drop is instilled in the affected eye(s) once daily, but the exact schedule should follow the prescriber’s instructions.

Safety data for Jokath in pregnancy and lactation are limited. It should be used only if the potential benefit outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To order Jokath, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Jokath combines a beta‑blocker (timolol) and a prostaglandin analog (travoprost) in a single formulation, offering dual mechanisms of action. This can simplify treatment compared with using separate agents, potentially improving adherence while delivering comparable intra‑ocular pressure reduction to other combination therapies.

Jokath should be stored at room temperature, away from direct sunlight and moisture. Keep the bottle tightly closed in its original packaging until use, and discard any solution that appears discolored or contaminated.

Jokath is applied as an eye drop. The patient should wash hands, tilt the head back, pull down the lower eyelid to create a pocket, and place one drop into the conjunctival sac of the affected eye(s). Close the eye gently and avoid blinking excessively for a few seconds.

Serious risks include severe allergic reactions, significant eye pain or sudden loss of vision, and systemic beta‑blocker effects such as bradycardia, hypotension, or bronchospasm. Patients should seek immediate medical attention if any of these symptoms occur.

Jokath is contraindicated in patients with known hypersensitivity to timolol, travoprost, or any component of the formulation. It should also be avoided in individuals with severe asthma, untreated cardiac conduction disorders, or those using non‑selective systemic beta‑blockers without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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