Product image of Jomezal (Ketoprofen Lysine) supplied by GNH India

Jomezal

Active Ingredient:
Ketoprofen Lysine
Origin:
EU

Jomezal (Ketoprofen Lysine)

Ketoprofen lysine, the active ingredient in Jomezal, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is employed to relieve mild to moderate pain and to reduce inflammation in conditions such as rheumatoid arthritis and musculoskeletal disorders.

GNH India supplies Jomezal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for export markets. Clients benefit from reliable logistics and responsive technical support throughout the supply chain.

Manufacturer / TM Owner

Cross Pharmaceuticals P.C.

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Indications & Clinical Uses

Jomezal (ketoprofen lysine) is used to manage pain and inflammation associated with several musculoskeletal and rheumatic conditions.

  • Mild to moderate pain: provides analgesic relief for acute or chronic pain such as dental or postoperative discomfort.
  • Rheumatoid arthritis: reduces joint inflammation and swelling, improving mobility.
  • Musculoskeletal pain: alleviates pain from strains, sprains, and osteoarthritis.

How It Works

  • Ketoprofen lysine exerts its effect by non‑selectively inhibiting cyclooxygenase enzymes COX‑1 and COX‑2. This inhibition blocks the conversion of arachidonic acid to prostaglandins, which are mediators of inflammation, pain and fever. By decreasing prostaglandin levels in inflamed tissues, the drug also limits vasodilation and edema, contributing to its therapeutic benefit.

Side Effects

Ketoprofen lysine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or pruritus.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Renal impairment or acute kidney injury.
  • Severe hypersensitivity reactions such as Stevens‑Johnson syndrome.
  • Hepatic dysfunction or elevated liver enzymes.

Precautions & Warnings

When prescribing Jomezal, clinicians should consider several precautionary measures to minimise risk.

  • Assess gastrointestinal risk: evaluate history of ulcers, bleeding or concurrent NSAID use.
  • Evaluate renal function: monitor serum creatinine and avoid in severe renal impairment.
  • Monitor cardiovascular status: use caution in patients with hypertension or heart disease.
  • Use the lowest effective dose for the shortest duration necessary.
  • Avoid in patients with known hypersensitivity to ketoprofen or other NSAIDs.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Ketoprofen lysine can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: heightened risk of ulceration and bleeding.
  • ACE inhibitors or ARBs: may reduce renal perfusion and function.

Moderate Interactions (Monitor Closely)

  • Diuretics: possible reduction in renal clearance.
  • Methotrexate: decreased excretion leading to toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): modestly increased bleeding risk.
  • Oral hypoglycemic agents: may enhance hypoglycaemic effect.

Frequently Asked Questions

Jomezal contains ketoprofen lysine, an NSAID indicated for the relief of mild to moderate pain and for reducing inflammation in conditions such as rheumatoid arthritis, osteoarthritis and other musculoskeletal disorders.

Ketoprofen lysine works by non‑selectively blocking the cyclooxygenase enzymes COX‑1 and COX‑2, which reduces the synthesis of prostaglandins—key mediators of pain, fever and inflammation—thereby providing analgesic and anti‑inflammatory effects.

The appropriate dose of Jomezal is determined by the prescribing healthcare professional based on the patient’s condition, age, weight and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for ketoprofen lysine in pregnancy and lactation are limited. It is generally advised to avoid use unless clearly needed and prescribed by a qualified clinician, as potential risks to the fetus or infant cannot be ruled out.

To order Jomezal, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoprofen lysine generally offers a longer duration of analgesic effect compared with ibuprofen, allowing potentially fewer daily doses. Both belong to the same NSAID class and share similar mechanisms, but individual tolerability, drug‑interaction profiles and specific clinical guidelines may influence the choice of therapy.

Jomezal should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and heat sources to maintain stability and potency throughout its shelf life.

Jomezal is taken orally, usually with a full glass of water. It may be taken with or without food, but taking it with meals can help reduce the likelihood of gastrointestinal discomfort.

Serious risks include gastrointestinal ulceration or bleeding, renal impairment, severe allergic reactions such as Stevens‑Johnson syndrome, and hepatic dysfunction. Patients should seek immediate medical attention if they experience symptoms like black stools, sudden kidney problems, rash with blistering, or jaundice.

Jomezal should be avoided in individuals with known hypersensitivity to ketoprofen, other NSAIDs, or any of its excipients, as well as in patients with active peptic ulcer disease, severe renal or hepatic impairment, and those on anticoagulant therapy without close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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