Product image of Jomil (Tamsulosin Hydrochloride, Solifenacin Succinate) supplied by GNH India

Jomil

Active Ingredient:
Tamsulosin Hydrochloride, Solifenacin Succinate
Origin:
EU

Jomil (Tamsulosin Hydrochloride, Solifenacin Succinate)

Tamsulosin Hydrochloride and Solifenacin Succinate, the active ingredients in Jomil, are an Alpha‑1 adrenergic antagonist and a muscarinic antagonist presented as an oral tablet for systemic use. They treat lower urinary tract symptoms associated with benign prostatic hyperplasia and overactive bladder in adult males and females, by selectively blocking receptors in the prostate, bladder neck, and detrusor muscle, thereby improving urine flow and reducing urgency.

GNH India supplies Jomil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Heaton K.S.

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Indications & Clinical Uses

Jomil combines tamsulosin and solifenacin to address urinary tract conditions that involve prostate enlargement and bladder overactivity.

  • Benign prostatic hyperplasia (BPH): alleviates urinary obstruction and improves urine flow.
  • Overactive bladder (OAB): decreases urgency episodes, frequency, and urge incontinence.
  • Urinary frequency: reduces daytime voiding episodes, improving quality of life.
  • Nocturia: decreases nighttime awakenings due to bladder contractions.

How It Works

  • Tamsulosin selectively blocks alpha‑1 adrenergic receptors in the prostate and bladder neck, relaxing smooth muscle and facilitating urine flow. Solifenacin antagonizes M3 muscarinic receptors on the detrusor muscle, reducing involuntary contractions and bladder urgency. The combined action addresses both obstructive and storage symptoms of lower urinary tract disorders.

Side Effects

Jomil may cause a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Dizziness or light‑headedness.
  • Dry mouth.
  • Constipation.
  • Abnormal ejaculation.
  • Blurred vision.

Serious or Rare Side Effects

  • Severe hypotension or syncope.
  • Acute urinary retention.
  • Allergic reactions such as rash, angioedema, or anaphylaxis.

Precautions & Warnings

Before initiating therapy with Jomil, consider the following precautions.

  • Assess renal function: adjust use in severe impairment.
  • Monitor cardiovascular status: watch for orthostatic hypotension.
  • Avoid in patients with existing urinary retention.
  • Review concomitant medications: especially CYP3A4 inhibitors or other anticholinergics.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Jomil can interact with several drug classes; awareness of these interactions helps maintain safety and efficacy.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase plasma concentrations of both components.
  • Strong CYP3A4 inducers (e.g., rifampin): may reduce therapeutic effect.
  • Other alpha‑blockers (e.g., prazosin): additive hypotensive effect.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents (e.g., diphenhydramine): may enhance anticholinergic burden.
  • Diuretics: can exacerbate orthostatic hypotension, especially at treatment initiation.

Frequently Asked Questions

Jomil is prescribed for adults with benign prostatic hyperplasia (BPH) who experience lower urinary tract symptoms, as well as for individuals with overactive bladder (OAB) who have urgency, frequency, or urge incontinence. The combination addresses both obstructive and storage symptoms to improve urinary flow and bladder control.

Tamsulosin blocks alpha‑1 receptors in the prostate and bladder neck, relaxing smooth muscle and easing urine passage. Solifenacin blocks M3 muscarinic receptors in the bladder detrusor muscle, reducing involuntary contractions and urgency. Together they target the two main mechanisms that cause urinary obstruction and overactivity.

The appropriate dose of Jomil is determined by the prescribing healthcare professional based on the patient’s clinical condition, response, and any comorbidities. Dosage adjustments may be required for renal or hepatic impairment, and the prescriber will provide specific instructions.

Safety data for Jomil in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To request Jomil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

For BPH, tamsulosin alone is a common alpha‑blocker, while Jomil adds solifenacin to also address bladder overactivity. Compared with antimuscarinic monotherapy for OAB, Jomil provides the added benefit of relieving prostate‑related obstruction. The combination may reduce the need for multiple separate prescriptions but requires monitoring for combined side‑effects.

Jomil should be stored at ambient temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the tablet container tightly closed and out of reach of children.

Jomil is taken orally, usually once daily, with or without food as directed by the prescriber. Swallow the tablet whole with a full glass of water and follow any specific timing instructions provided by the healthcare professional.

Serious risks include severe hypotension or syncope, acute urinary retention, and rare allergic reactions such as rash, angioedema, or anaphylaxis. Patients should seek immediate medical attention if they experience fainting, inability to urinate, or signs of a severe allergic response.

Jomil is contraindicated in patients with known hypersensitivity to tamsulosin, solifenacin, or any excipients, as well as in individuals with severe urinary retention, uncontrolled narrow‑angle glaucoma, or those taking strong CYP3A4 inhibitors that could raise drug levels. Pregnant women should avoid use unless clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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