Product image of Jonosteril D5 (Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calcium Chloride Dihydrate, Glu) supplied by GNH India

Jonosteril D5

Active Ingredient:
Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calcium Chloride Dihydrate, Glu
Origin:
EU

Jonosteril D5 (Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calcium Chloride Dihydrate, Glu)

Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calcium Chloride Dihydrate and Glucose, the active ingredients in Jonosteril D5, are an electrolyte solution presented as an intravenous solution for injection use. It provides fluid and electrolyte replacement for patients with hypovolemia, electrolyte imbalance, or those requiring peri‑operative fluid management.
GNH India supplies Jonosteril D5 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Deutschland Gmbh

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Indications & Clinical Uses

Jonosteril D5 is an intravenous electrolyte solution used to restore fluid balance and correct electrolyte disturbances.

  • Fluid replacement: rehydrates patients with acute volume loss.
  • Electrolyte imbalance correction: normalises sodium, potassium, calcium and magnesium levels.
  • Hypovolemia treatment: supports circulatory volume in trauma or surgical settings.
  • Peri‑operative fluid management: maintains electrolyte homeostasis during surgery.

How It Works

  • Jonosteril D5 delivers sodium, potassium, calcium, magnesium and glucose directly into the bloodstream, expanding extracellular fluid volume and restoring osmotic balance. The supplied ions participate in cellular electrical activity, muscle contraction and enzymatic processes, while glucose provides an immediate energy source, together correcting deficits caused by loss or inadequate intake.

Side Effects

Jonosteril D5 may cause a range of infusion‑related reactions.

Common Side Effects

  • Infusion site irritation or pain.
  • Mild hypernatremia or hyponatremia.
  • Transient hyperkalemia.
  • Slight elevation of serum calcium.
  • Hyperglycemia in susceptible patients.
  • Mild headache or nausea.

Serious or Rare Side Effects

  • Severe electrolyte disturbances leading to cardiac arrhythmia.
  • Anaphylactic or severe hypersensitivity reaction.
  • Pulmonary edema from fluid overload.
  • Metabolic acidosis.
  • Acute kidney injury due to rapid shifts in electrolytes.
  • Thrombophlebitis at the infusion site.

Precautions & Warnings

Jonosteril D5 should be administered with careful clinical monitoring.

  • Assess electrolyte status: obtain baseline serum electrolytes before infusion.
  • Monitor fluid balance: track input and output to avoid overload.
  • Adjust dose in renal impairment: reduce volume or concentration as needed.
  • Use caution in patients with heart failure or hypertension.
  • Avoid concurrent administration with other high‑electrolyte IV fluids without adjustment.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Jonosteril D5 can interact with other medications that affect electrolyte or fluid balance.

Major Interactions (Avoid)

  • Concomitant potassium‑sparing diuretics or high‑potassium supplements: risk of severe hyperkalemia.
  • Calcium channel blockers combined with high calcium loads: may precipitate hypercalcemia.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: monitor renal function and potassium levels.
  • NSAIDs: may impair renal clearance of electrolytes.
  • Insulin therapy: glucose content may require insulin dose adjustment.
  • Other IV fluids: coordinate electrolyte concentrations to prevent overload.

Frequently Asked Questions

Jonosteril D5 is an intravenous electrolyte solution used to replace lost fluids and correct imbalances of sodium, potassium, calcium, magnesium and glucose. It is indicated for patients with hypovolemia, electrolyte disturbances, or those needing fluid support during surgery or trauma care.

The solution provides essential ions and glucose directly into the bloodstream, expanding extracellular fluid volume and restoring osmotic equilibrium. The supplied electrolytes participate in nerve conduction, muscle contraction and enzymatic reactions, while glucose supplies immediate metabolic energy, together normalising the patient’s fluid‑electrolyte status.

The dose of Jonosteril D5 is determined by the prescribing clinician based on the patient’s weight, clinical condition, electrolyte levels and fluid losses. Healthcare professionals calculate the appropriate volume and rate of infusion to safely achieve the desired fluid and electrolyte replacement.

Safety data for Jonosteril D5 in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Jonosteril D5, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Jonosteril D5 offers a balanced combination of sodium, potassium, calcium, magnesium and glucose in a single formulation, which can reduce the need for multiple separate infusions. Compared with simpler saline solutions, it addresses a broader range of electrolyte deficits and provides an energy source, making it suitable for complex fluid‑replacement scenarios.

Jonosteril D5 must be stored at 2‑8 °C, protected from light, and should never be frozen or shaken. Keep the product in its original packaging until use and discard any solution that appears discoloured or contains particles.

Jonosteril D5 is administered intravenously. The solution is typically infused through a peripheral or central venous line, with the rate and total volume determined by the clinician based on the patient’s fluid status, electrolyte measurements and overall clinical picture.

Serious risks include severe electrolyte disturbances that can lead to cardiac arrhythmias, anaphylactic reactions, pulmonary edema from fluid overload, and metabolic acidosis. Continuous monitoring of vital signs, electrolyte levels and fluid balance is essential to mitigate these risks.

Jonosteril D5 should be avoided in patients with known hypersensitivity to any of its components, in those with uncontrolled hyperkalemia or hypercalcemia, and in individuals where fluid overload could exacerbate heart failure or severe renal impairment unless closely monitored by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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