Product image of Juliette (Cyproterone Acetate, Ethinylestradiol) supplied by GNH India

Juliette

Active Ingredient:
Cyproterone Acetate, Ethinylestradiol
Origin:
EU

Juliette (Cyproterone Acetate, Ethinylestradiol)

Cyproterone acetate / ethinylestradiol, the active ingredients in Juliette, are a combined oral contraceptive presented as a tablet for oral use. They work by suppressing ovulation and stabilising the endometrium, thereby preventing pregnancy in women of reproductive age.

GNH India supplies Juliette as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable access to this EU‑approved contraceptive.

Manufacturer / TM Owner

Exeltis Germany Gmbh

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Indications & Clinical Uses

  • Juliette, a combined oral contraceptive, is used to prevent pregnancy by acting on the hormonal regulation of the menstrual cycle.
  • Contraception: prevention of pregnancy in women of reproductive age.
  • Acne: reduction of androgen‑dependent acne lesions.
  • Hirsutism: decrease in excessive facial or body hair growth.

How It Works

  • Cyproterone acetate acts as a progestogenic antagonist of androgen receptors and suppresses gonadotropin release, while ethinylestradiol provides estrogenic activity that stabilises the endometrium and enhances cervical mucus viscosity. Together they inhibit the mid‑cycle LH surge, preventing ovulation and creating an environment hostile to fertilisation.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like pain.
  • Breast tenderness: swelling or discomfort.
  • Spotting: irregular breakthrough bleeding.
  • Weight gain: modest increase in body weight.
  • Mood changes: irritability or emotional lability.

Serious or Rare Side Effects

  • Venous thromboembolism: deep‑vein clot formation.
  • Pulmonary embolism: blockage of lung arteries.
  • Stroke or myocardial infarction: cerebrovascular or cardiac events.
  • Severe liver dysfunction: jaundice or hepatic failure.
  • Allergic reactions: rash, swelling, or anaphylaxis.
  • Visual disturbances: sudden loss of vision or blurred sight.

Precautions & Warnings

Juliette should be used with caution and under medical supervision.

  • Pregnancy contraindication: do not use during pregnancy.
  • Smoking restriction: avoid if over 35 years and a smoker.
  • Thromboembolic history: contraindicated in patients with prior clotting disorders.
  • Liver disease: avoid in severe hepatic impairment.
  • Hypertension: monitor blood pressure regularly.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Juliette may interact with several medicines that alter its efficacy or safety.

Major Interactions (Avoid)

  • Enzyme inducers (e.g., rifampin, carbamazepine): reduce contraceptive effect.
  • Anticoagulants (e.g., warfarin): may increase clotting risk.
  • HIV protease inhibitors: can diminish hormonal activity.

Moderate Interactions (Monitor Closely)

  • Antifungals (e.g., ketoconazole): may increase hormone levels.
  • Antidepressants (SSRIs): possible alteration of menstrual bleeding.
  • Anticonvulsants (e.g., phenytoin): may lower contraceptive reliability.

Frequently Asked Questions

Juliette is a combined oral contraceptive that contains cyproterone acetate and ethinylestradiol. It is prescribed to prevent pregnancy in women of reproductive age by inhibiting ovulation and creating a cervical mucus environment that reduces the chance of fertilisation.

Cyproterone acetate acts as a progestogen and an anti‑androgen. It suppresses the release of gonadotropins from the pituitary, which blocks the mid‑cycle surge of luteinising hormone required for ovulation, while also counteracting androgen effects that can cause acne or hirsutism.

The dosing regimen for Juliette is determined by the prescribing clinician. Typically, it is taken as a daily oral tablet following the specific cycle schedule indicated on the prescription, but the exact dose and duration should always be confirmed with a qualified healthcare professional.

Juliette is classified as pregnancy category X, meaning it must not be used during pregnancy because it can cause fetal harm. It is also not recommended while breastfeeding, as hormones may pass into breast milk and affect the infant. Women should consult their doctor for alternative options.

To order Juliette, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Juliette contains cyproterone acetate, which provides additional anti‑androgenic activity compared with many other combined pills that use levonorgestrel or desogestrel. This can be advantageous for patients with acne or hirsutism, while its contraceptive efficacy remains comparable to other estrogen‑progestogen combinations.

Juliette tablets should be stored at room temperature, below 25 °C, in the original blister pack. Keep them away from moisture, heat and direct sunlight to maintain product stability throughout the shelf life.

Juliette is taken orally, usually once daily at the same time each day. The tablets are swallowed whole with water and should be started according to the prescribing schedule, often on the first day of the menstrual period or as directed by a healthcare provider.

The most serious risks include venous thromboembolism, pulmonary embolism, stroke, myocardial infarction, severe liver dysfunction and allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience symptoms like sudden chest pain, shortness of breath, severe abdominal pain, or skin rash.

Juliette is contraindicated in women who are pregnant, have a history of thromboembolic disorders, uncontrolled hypertension, severe liver disease, known hypersensitivity to any component, or who smoke heavily and are over 35 years old. A thorough medical assessment is required before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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