Product image of Juliette (Tibolone) supplied by GNH India

Juliette

Active Ingredient:
Tibolone
Origin:
EU

Juliette (Tibolone)

Tibolone, the active ingredient in Juliette, is a synthetic steroid presented as an oral tablet for oral use. It relieves menopausal symptoms and helps prevent osteoporosis in postmenopausal women.\n\nGNH India supplies Juliette as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ioulia And Irene Tseti Pharmaceutical Laboratories S.A.

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Indications & Clinical Uses

  • Juliette is a synthetic steroid that acts on estrogen, progestogen and androgen pathways to manage menopause‑related conditions.\n\n- Menopausal vasomotor symptoms: reduces hot flashes and night sweats.\n- Menopausal mood disturbances: improves mood and sleep quality.\n- Postmenopausal osteoporosis: helps maintain bone mineral density.

How It Works

  • Tibolone is rapidly metabolized to three active compounds that bind estrogen, progesterone and androgen receptors. The estrogenic metabolites alleviate vasomotor and urogenital symptoms, the progestogenic activity opposes estrogen‑induced endometrial proliferation, and the androgenic component contributes to bone‑protective effects and libido improvement.

Side Effects

  • Common side effects are generally mild and transient.\n\nCommon Side Effects:\n- Nausea\n- Headache\n- Breast tenderness\n- Weight gain\n- Mood changes\n\nSerious or Rare Side Effects:\n- Deep vein thrombosis\n- Pulmonary embolism\n- Liver dysfunction

Precautions & Warnings

  • Before initiating therapy, clinicians should evaluate individual risk factors and monitor patients regularly.\n\n- Assess cardiovascular risk: review history of thromboembolic disease.\n- Monitor bone health: obtain baseline densitometry.\n- Screen for hormone‑sensitive cancers: consider prior history.\n- Avoid in active liver disease: contraindicated.\n- Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

  • Tibolone may interact with several drug classes; some combinations should be avoided while others require close monitoring.\n\nMajor Interactions (Avoid):\n- Combined estrogen therapy: increased risk of thromboembolism.\n- Anticoagulants: may reduce anticoagulant efficacy.\n- CYP450 inducers (e.g., rifampicin): may lower tibolone plasma levels.\n\nModerate Interactions (Monitor Closely):\n- Selective serotonin reuptake inhibitors: possible additive mood effects.\n- Tamoxifen: antagonistic effect on estrogen receptors.\n- Carbamazepine: may decrease tibolone concentrations.

Frequently Asked Questions

Juliette contains tibolone and is prescribed to alleviate menopausal symptoms such as hot flashes, night sweats, and mood changes, as well as to help prevent bone loss and osteoporosis in postmenopausal women.

Tibolone is converted in the body to three metabolites that act on estrogen, progesterone and androgen receptors, providing estrogen‑like relief of vasomotor symptoms, progestogenic protection of the endometrium, and androgenic support for bone density and libido.

The dosage of Juliette is determined by the prescribing clinician based on the individual’s health status, severity of symptoms, and treatment goals. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Tibolone is not indicated for use in pregnant or breastfeeding women. It may affect fetal development and hormone levels in nursing infants, so it should be avoided in these populations unless the benefits clearly outweigh the risks.

To place an order, submit an enquiry on the Juliette product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike traditional estrogen‑progestogen combinations, tibolone provides a balanced estrogenic, progestogenic and androgenic profile in a single molecule, which can result in fewer endometrial concerns and added benefits for bone health, though individual response and risk profiles vary.

Juliette should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiration date.

Juliette is taken orally, usually once daily, with or without food as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed.

The most serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, and rare cases of liver dysfunction. Patients should be monitored for signs of blood clots, abdominal pain, jaundice or unexplained fatigue.

Juliette is contraindicated in women with a history of breast or endometrial cancer, active liver disease, unexplained vaginal bleeding, or known thromboembolic disorders. It should also be avoided in pregnant or breastfeeding women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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