Product image of Juteo (Tamsulosin Hydrochloride, Dutasteride) supplied by GNH India

Juteo

Active Ingredient:
Tamsulosin Hydrochloride, Dutasteride
Origin:
EU

Juteo (Tamsulosin Hydrochloride, Dutasteride)

Tamsulosin hydrochloride and dutasteride, the active ingredients in Juteo, are an alpha‑1 adrenergic antagonist and a 5‑alpha‑reductase inhibitor presented as an oral tablet for oral use. It treats benign prostatic hyperplasia in adult men by improving urine flow and reducing prostate size.
GNH India supplies Juteo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline - Produtos Farmaceuticos, Lda

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Indications & Clinical Uses

Juteo combines two agents that act on the prostate and lower urinary tract to manage benign prostatic hyperplasia and its symptoms.

  • Benign prostatic hyperplasia: relieves urinary obstruction and improves flow rate.
  • Lower urinary tract symptoms due to BPH: reduces urgency, frequency and nocturia.
  • Prostate enlargement: decreases prostate volume over time, helping to prevent disease progression.

How It Works

  • Tamsulosin selectively blocks alpha‑1 adrenergic receptors in prostatic smooth muscle, causing relaxation and improved urinary outflow. Dutasteride inhibits both type 1 and type 2 5‑alpha‑reductase enzymes, lowering dihydrotestosterone production, which leads to a gradual reduction in prostate gland size. The combined action addresses both dynamic and static components of BPH.

Side Effects

Juteo may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Dizziness or light‑headedness, especially on standing.
  • Abnormal ejaculation or reduced libido.
  • Headache.
  • Nasal congestion or runny nose.
  • Orthostatic hypotension.

Serious or Rare Side Effects

  • Intraoperative floppy iris syndrome during cataract surgery.
  • Severe hypotension requiring medical attention.
  • Allergic reactions such as rash, swelling or anaphylaxis.
  • Priapism (prolonged erection).

Precautions & Warnings

Before prescribing Juteo, clinicians should consider several safety measures.

  • Blood pressure monitoring: watch for orthostatic drops, especially after the first dose.
  • Hepatic function: adjust use in patients with moderate liver impairment.
  • Cataract surgery: inform surgeons of possible intraoperative floppy iris syndrome.
  • Concomitant alpha‑blockers: avoid additive hypotensive effects.
  • Prostate-specific antigen (PSA) testing: interpret results with caution as dutasteride lowers PSA levels.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Juteo can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Other alpha‑1 adrenergic antagonists (e.g., prazosin) – risk of profound hypotension.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) – increase dutasteride exposure.
  • Potent CYP2D6 inhibitors – may affect tamsulosin metabolism.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents (e.g., ACE inhibitors, diuretics) – monitor blood pressure.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil) – may enhance hypotensive effect.
  • Non‑steroidal anti‑inflammatory drugs – increase risk of renal impairment with hypotension.

Frequently Asked Questions

Juteo is indicated for the treatment of benign prostatic hyperplasia (BPH) in adult men. It helps relieve urinary obstruction, improves flow, and reduces prostate size by combining an alpha‑1 blocker with a 5‑alpha‑reductase inhibitor.

Tamsulosin hydrochloride selectively blocks alpha‑1 adrenergic receptors in the smooth muscle of the prostate and bladder neck. This relaxation reduces resistance to urine flow, easing symptoms such as difficulty starting urination and weak stream.

The specific dose of Juteo is determined by the prescribing clinician based on the patient’s condition, age, renal and hepatic function, and other medications. Healthcare professionals tailor the regimen to achieve optimal therapeutic effect while minimizing risk.

Juteo is not recommended for use in pregnancy or while breastfeeding because the active ingredients may affect fetal development and are excreted in breast milk. Women who are pregnant, planning pregnancy, or nursing should discuss alternative treatments with their physician.

To order Juteo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Juteo combines two mechanisms—alpha‑1 blockade and 5‑alpha‑reductase inhibition—in a single tablet, offering both rapid symptom relief and long‑term prostate size reduction. Single‑agent alpha‑blockers act quickly but do not shrink the gland, while 5‑alpha‑reductase inhibitors work slower but reduce volume; Juteo provides the benefits of both.

Juteo should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, direct sunlight and heat sources to maintain stability and potency throughout its shelf life.

Juteo is taken orally, usually once daily, with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush, chew, or split unless specifically instructed by a healthcare professional.

Serious risks include intraoperative floppy iris syndrome during cataract surgery, severe hypotension that can lead to fainting, and rare allergic reactions such as rash, swelling or anaphylaxis. Patients should report any sudden vision changes, dizziness, or signs of an allergic response promptly.

Juteo is contraindicated in patients with known hypersensitivity to tamsulosin, dutasteride, or any excipients. It should also be avoided in individuals undergoing cataract surgery without informing the surgeon, and in patients taking other potent alpha‑blockers or strong CYP3A4 inhibitors without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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