Product image of K-Drops (Ketotifen Hydrogen Fumarate) supplied by GNH India

K-Drops

Active Ingredient:
Ketotifen Hydrogen Fumarate
Origin:
EU

K-Drops (Ketotifen Hydrogen Fumarate)

Ketotifen hydrogen fumarate, the active ingredient in K-Drops, is an antihistamine (H1 receptor antagonist) and mast cell stabilizer presented as eye drops for ocular use. It alleviates allergic conjunctivitis, seasonal allergic eye disease, and ocular itching and redness caused by allergy.

GNH India supplies K-Drops as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution. These products meet EU pharmacopeial specifications and are available in bulk or retail packaging.

Manufacturer / TM Owner

Εξελιξη Α.Ε.

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Indications & Clinical Uses

  • K-Drops (ketotifen hydrogen fumarate) is used to manage allergic eye conditions by inhibiting histamine‑mediated responses.
  • Allergic conjunctivitis: Reduces inflammation, itching and redness in the conjunctiva.
  • Seasonal allergic eye disease: Controls seasonal flare‑ups of ocular allergy symptoms.
  • Ocular itching and redness due to allergy: Provides rapid relief of itching, burning and hyperemia.

How It Works

  • Ketotifen hydrogen fumarate blocks H1 histamine receptors on conjunctival cells and stabilises mast cells, preventing degranulation and the release of inflammatory mediators such as histamine, leukotrienes and prostaglandins. This dual action reduces vascular permeability, edema and sensory nerve activation, leading to decreased ocular itching, redness and swelling.

Side Effects

K-Drops is generally well tolerated, but ocular preparations can cause local reactions.

Common Side Effects

  • Transient burning or stinging sensation after instillation.
  • Mild eye irritation or foreign‑body feeling.
  • Temporary blurred vision.
  • Increased tear production.
  • Conjunctival hyperemia (redness).
  • Mild eyelid swelling.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angio‑edema of the eyelid).
  • Corneal ulcer or epithelial defect.
  • Persistent eye pain or photophobia.
  • Significant visual acuity changes.
  • Secondary ocular infection.
  • Anaphylaxis (extremely rare).

Precautions & Warnings

  • Before using K-Drops, consider the following safety measures.
  • Pregnancy: Safety not established; use only if clearly needed.
  • Breastfeeding: Unknown excretion; weigh benefits against potential risks.
  • Contact lens wearers: Remove lenses before instillation and wait several minutes before reinserting.
  • Concurrent ocular infection: Do not use until infection is resolved.
  • Hypersensitivity: Avoid if known allergy to ketotifen or any excipient.
  • Store at room temperature: Keep in the original container, protect from light and moisture.

Avoid Interactions

K-Drops may interact with other ophthalmic or systemic agents.

Major Interactions (Avoid)

  • Use with other mast cell stabilisers may increase ocular irritation.
  • Concurrent topical vasoconstrictors can exacerbate local dryness.

Moderate Interactions (Monitor Closely)

  • Systemic antihistamines may potentiate local antihistaminic effect, leading to increased dryness.
  • Co‑administration with topical corticosteroids may mask signs of infection.
  • Use with preservative‑containing eye drops may increase risk of corneal toxicity.
  • Combination with ocular anesthetics may prolong numbness.
  • Concurrent use of glaucoma medications should be monitored for intra‑ocular pressure changes.

Frequently Asked Questions

K-Drops contains ketotifen hydrogen fumarate and is indicated for the relief of allergic conjunctivitis, seasonal allergic eye disease, and ocular itching or redness caused by allergy. It works locally in the eye to reduce inflammation and discomfort associated with these allergic eye conditions.

Ketotifen hydrogen fumarate blocks H1 histamine receptors on conjunctival cells and stabilises mast cells, preventing the release of histamine, leukotrienes and other inflammatory mediators. This dual action reduces vascular leakage, swelling and nerve activation, thereby alleviating itching, redness and swelling in the eye.

The dosing regimen for K-Drops is determined by the prescribing healthcare professional based on the severity of the allergic eye condition and patient response. Typically, one to two drops are instilled in the affected eye(s) as directed, but the exact frequency and duration should follow the prescriber’s instructions.

Safety data for ketotifen hydrogen fumarate in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their physician.

To request K-Drops, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will ask for trade or institutional credentials. The sales team will then provide pricing, availability, shipping details and any required import documentation.

K-Drops (ketotifen) combines H1‑receptor antagonism with mast‑cell stabilisation, offering both immediate symptom relief and longer‑term control of allergic inflammation. Other ocular antihistamines may provide only H1 blockade without stabilising mast cells, potentially requiring more frequent dosing for comparable effect.

K-Drops should be stored at room temperature, below 25 °C, in the original packaging. Keep the bottle tightly closed, protect it from direct light and moisture, and discard any product that appears discoloured or has particles after the expiry date.

K-Drops is applied topically to the eye. The patient should wash hands, tilt the head back, pull down the lower eyelid, and place the prescribed number of drops into the conjunctival sac. Close the eye gently for a few seconds and avoid blinking excessively to allow absorption.

Serious but rare risks include severe allergic reactions such as angio‑edema of the eyelid, corneal ulceration, persistent eye pain, significant visual changes, or secondary ocular infection. Any sudden worsening of eye symptoms should prompt immediate medical evaluation.

K-Drops should be avoided in individuals with known hypersensitivity to ketotifen hydrogen fumarate or any of the formulation excipients. Patients with active ocular infections, uncontrolled glaucoma, or those who have had a severe reaction to similar ophthalmic antihistamines should also refrain from use unless advised otherwise by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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