Product image of Ka-Vit Tropfen (Phytomenadione) supplied by GNH India

Ka-Vit Tropfen

Active Ingredient:
Phytomenadione
Origin:
EU

Ka-Vit Tropfen (Phytomenadione)

Phytomenadione, the active ingredient in Ka-Vit Tropfen, is a Vitamin K presented as oral drops for oral use. It supports normal blood clotting by addressing vitamin K deficiency and is employed in newborns to prevent hemorrhage and in patients requiring reversal of oral anticoagulant therapy.

GNH India supplies Ka-Vit Tropfen as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution. Customers benefit from reliable logistics, temperature-controlled shipping where required, and responsive technical support.

Manufacturer / TM Owner

Infectopharm Arzneimittel Und Consilium Gmbh, De, Heppenheim

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Indications & Clinical Uses

Ka-Vit Tropfen (phytomenadione) is used to correct impaired coagulation associated with vitamin K–dependent pathways.

  • Vitamin K deficiency: restores activity of clotting factors II, VII, IX and X.
  • Newborn hemorrhage prevention: provides prophylactic vitamin K to reduce risk of bleeding in infants.
  • Reversal of oral anticoagulant therapy: counteracts the effect of warfarin and similar agents to re‑establish normal clotting.

How It Works

  • Phytomenadione acts as a cofactor for the gamma‑carboxylation of glutamate residues on clotting factors II, VII, IX and X in the liver. This post‑translational modification enables the factors to bind calcium ions, which is essential for the assembly of the clotting cascade and restoration of normal hemostasis.

Side Effects

Adverse reactions may occur with oral vitamin K administration.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Vomiting: occasional emesis after dosing.
  • Diarrhea: loose stools in some patients.
  • Abdominal pain: transient discomfort.
  • Headache: mild tension‑type headache.
  • Skin rash: mild erythema or pruritus.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Hemolysis: rare destruction of red blood cells.
  • Elevated liver enzymes: possible hepatic irritation.
  • Thrombosis: uncommon formation of abnormal clots.
  • Severe hypersensitivity: including angioedema.
  • Hyperbilirubinemia: rare increase in bilirubin levels.

Precautions & Warnings

Before using Ka-Vit Tropfen, consider the following precautions.

  • Pregnancy: safety not established; use only if potential benefit justifies the risk.
  • Breastfeeding: unknown excretion in milk; evaluate risk versus benefit.
  • Renal impairment: monitor clotting status closely.
  • Concomitant anticoagulants: may reduce anticoagulant efficacy; adjust therapy as needed.
  • Bleeding disorders: assess baseline coagulation before administration.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Phytomenadione may interact with several medicines.

Major Interactions (Avoid)

  • Warfarin: antagonizes anticoagulant effect, potentially leading to clotting.
  • Broad‑spectrum antibiotics (e.g., cephalosporins): reduce intestinal vitamin K synthesis, diminishing efficacy.
  • Bile‑acid sequestrants: decrease absorption of oral vitamin K.

Moderate Interactions (Monitor Closely)

  • Vitamin K supplements: may alter therapeutic response.
  • Heparin: additive effect on clotting parameters.
  • Oral contraceptives: possible increased risk of thrombosis when combined with high vitamin K levels.

Frequently Asked Questions

Ka‑Vit Tropfen contains phytomenadione, a form of vitamin K, and is used to treat vitamin K deficiency, prevent bleeding in newborns, and reverse the anticoagulant effects of oral agents such as warfarin. It helps restore normal clotting factor activity in these clinical situations.

Phytomenadione serves as a cofactor for the gamma‑carboxylation of specific clotting factors (II, VII, IX, X) in the liver. This biochemical step enables the factors to bind calcium, which is essential for the formation of a stable fibrin clot and normal hemostasis.

The dose of Ka‑Vit Tropfen is individualized and determined by a qualified prescriber based on the patient’s age, clinical condition, and laboratory results. Healthcare professionals calculate the appropriate amount and frequency to achieve the desired therapeutic effect.

Safety data for phytomenadione in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother or infant outweighs any possible risk, and the decision should be made by a healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ka‑Vit Tropfen is an oral liquid formulation of phytomenadione, whereas many alternatives are available as injectable phytonadione or synthetic vitamin K analogues. Oral drops offer ease of administration, especially for infants and patients with needle aversion, but may have slower onset compared with parenteral preparations.

Store Ka‑Vit Tropfen at ambient temperature, preferably below 25 °C. Keep the bottle tightly closed in its original packaging, protect it from moisture and direct sunlight, and avoid freezing. Check the label for any specific expiry information before use.

Ka‑Vit Tropfen is administered orally using the calibrated dropper provided with the product. The prescribed number of drops is measured directly into the mouth or mixed with a small amount of food or liquid, as directed by the prescribing clinician.

Serious adverse reactions, although rare, include anaphylaxis, severe hypersensitivity, hemolysis, thrombosis, and significant liver enzyme elevations. Patients should be monitored for signs of allergic reaction, unexpected clot formation, or abnormal bleeding and seek immediate medical attention if these occur.

Ka‑Vit Tropfen should be avoided in individuals with known hypersensitivity to phytomenadione or any excipients in the formulation. It is also contraindicated in patients with documented severe vitamin K toxicity or those for whom vitamin K supplementation is medically inappropriate, as determined by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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