Kabiven Peri (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Kabiven Peri is used in parenteral nutrition to provide essential amino acids for patients who cannot receive enteral feeding.

• Parenteral nutrition in patients unable to receive enteral feeding: supplies a balanced amino acid profile to maintain nitrogen balance and support protein synthesis.
• Peri‑operative nutrition support: delivers essential amino acids to aid recovery and reduce catabolism after surgery.
• Critical care nutrition for intensive care patients: provides rapid amino acid supplementation to meet heightened metabolic demands.

• Kabiven Peri delivers a mixture of essential and non‑essential amino acids directly into the bloodstream. The amino acids serve as substrates for protein synthesis, replenish intracellular pools, and contribute to nitrogen balance. By bypassing the gastrointestinal tract, the solution ensures immediate availability of these building blocks, supporting tissue repair, immune function, and metabolic processes in patients receiving total parenteral nutrition.

Intravenous amino acid solutions may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

• Infusion site erythema or pain
• Nausea or vomiting
• Transient hyperglycemia
• Mild electrolyte disturbances (e.g., hypokalemia)
• Headache
• Elevated liver enzymes (mild)

Serious or Rare Side Effects

• Anaphylactic or severe hypersensitivity reactions
• Metabolic acidosis
• Significant renal impairment or oliguria
• Hepatic dysfunction with marked transaminase rise
• Thrombophlebitis at the catheter site
• Severe hyperosmolarity leading to neurologic symptoms

When using Kabiven Peri, clinicians should observe several precautionary measures to ensure patient safety.

• Renal function: monitor serum creatinine and urine output regularly.
• Hepatic function: assess liver enzymes and bilirubin before and during therapy.
• Electrolyte balance: check serum electrolytes (Na, K, Ca, Mg, phosphate) frequently.
• Blood glucose: monitor for hyperglycemia, especially in diabetic patients.
• Allergy history: evaluate for known hypersensitivity to amino acids or solution components.
• Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Kabiven Peri may interact with other intravenous therapies or systemic medications, requiring careful management.

Major Interactions (Avoid)

• Co‑administration with calcium‑containing solutions: risk of precipitation and catheter blockage.
• Simultaneous infusion of high‑dose amino acid preparations: may cause nitrogen overload and metabolic disturbances.

Moderate Interactions (Monitor Closely)

• Insulin therapy: amino acid infusion can raise blood glucose, requiring insulin dose adjustment.
• Loop diuretics: may exacerbate electrolyte shifts during amino acid administration.
• Renal replacement therapy: can alter amino acid clearance, affecting dosing requirements.