Kabiven Perifer (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

• Kabiven Perifer, an amino acid solution used in parenteral nutrition, supports protein synthesis in patients who cannot receive enteral feeding.
• Parenteral nutrition for patients unable to tolerate enteral feeding: provides essential amino acids to meet protein needs when oral or tube feeding is not possible.
• Perioperative protein support: helps maintain nitrogen balance and tissue repair during the surgical period.
• Critical illness nutrition support: supplies necessary amino acids to counter catabolism in severely ill patients.

• Kabiven Perifer delivers a balanced mixture of essential amino acids directly into the bloodstream, supplying the substrates required for protein synthesis, nitrogen balance, and cellular metabolism. The amino acids are taken up by tissues to support the synthesis of structural and functional proteins, aid in wound healing, and maintain immune function during periods when oral intake is insufficient or impossible.

Common Side Effects

• Hyperglycemia: elevated blood glucose levels during infusion.
• Electrolyte disturbances: changes in sodium, potassium, or phosphate concentrations.
• Infusion site reactions: redness, swelling, or discomfort at the catheter site.
• Mild nausea or vomiting.

Serious or Rare Side Effects

• Anaphylactic reaction: severe allergic response requiring immediate medical attention.
• Severe metabolic acidosis: significant pH imbalance in the blood.
• Hepatic dysfunction: abnormal liver enzyme elevations.
• Renal failure: impaired kidney function due to excess nitrogen load.

Kabiven Perifer should be used with careful clinical monitoring.

• Blood glucose monitoring: check glucose levels regularly, especially in diabetic patients.
• Electrolyte monitoring: assess serum electrolytes before and during therapy.
• Renal and hepatic function: adjust dosage in patients with impaired kidney or liver function.
• Hypersensitivity: avoid use in individuals with known allergy to any amino acid component.
• Aseptic technique: ensure sterile handling to prevent contamination.
• Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Kabiven Perifer may interact with other medications and solutions.

Major Interactions (Avoid)

• High-dose potassium supplements: risk of hyperkalemia.
• Concurrent parenteral nutrition admixtures: potential for amino acid excess.
• Nephrotoxic drugs: increased risk of renal impairment.

Moderate Interactions (Monitor Closely)

• Insulin therapy: may require dose adjustments due to hyperglycemia.
• Loop diuretics: monitor electrolytes for shifts.
• Corticosteroids: may enhance protein catabolism, affecting nutritional balance.