Kabiven Perifer (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Kabiven Perifer is an amino acid solution used in the context of parenteral nutrition to address protein and metabolic needs.

• Inadequate enteral intake: provides essential amino acids to meet nutritional requirements when oral or tube feeding is insufficient.
• Post‑operative or trauma care: supplies amino acids to support wound healing and catabolic stress in surgical and trauma patients.
• Critical illness: maintains protein balance and metabolic support for critically ill patients receiving peripheral parenteral nutrition.

• Kabiven Perifer delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream. These amino acids are taken up by cells and incorporated into newly synthesized proteins, supporting tissue repair, enzyme production, and nitrogen balance while fulfilling the metabolic demands of patients receiving parenteral nutrition.

Kabiven Perifer may be associated with a range of infusion‑related reactions.

Common Side Effects

• Hyperglycemia: elevated blood glucose levels during infusion.
• Electrolyte disturbances: changes in serum potassium, sodium, or calcium.
• Infusion site irritation: redness, pain, or phlebitis at the catheter site.
• Nausea or vomiting: gastrointestinal discomfort during or after administration.
• Mild fever or chills: transient temperature rise.
• Headache: occasional mild headache.

Serious or Rare Side Effects

• Anaphylactic reaction: severe allergic response requiring immediate medical attention.
• Metabolic acidosis: significant acid‑base imbalance.
• Hyperammonemia: elevated ammonia levels, especially in hepatic impairment.
• Renal dysfunction: worsening kidney function in susceptible patients.
• Thrombophlebitis: clot formation with vein inflammation.
• Severe electrolyte imbalance: life‑threatening potassium or calcium shifts.

When using Kabiven Perifer, clinicians should observe several safety measures.

• Renal function: monitor patients with impaired kidney function closely.
• Electrolyte balance: check serum electrolytes before and during therapy.
• Metabolic monitoring: watch for hyperglycemia and acid‑base changes.
• Infusion rate: adhere to prescribed rates to avoid fluid overload.
• Compatibility: verify compatibility with other intravenous solutions before mixing.
• Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Kabiven Perifer can interact with other intravenous agents and systemic medications.

Major Interactions (Avoid)

• Concurrent high‑dose potassium solutions: may cause dangerous hyperkalemia.
• Calcium‑containing admixtures: can precipitate and obstruct catheters.

Moderate Interactions (Monitor Closely)

• Dextrose‑rich solutions: may exacerbate hyperglycemia.
• Loop diuretics: can alter electrolyte homeostasis.
• Other parenteral nutrition components: may require dose adjustments to maintain balance.