Product image of Kabiven Perifer (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Kabiven Perifer

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Kabiven Perifer (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin, the active ingredient in Kabiven Perifer, is a parenteral nutrition solution presented as a solution for injection for intravenous use. It provides essential amino acids for patients who cannot receive enteral feeding, supporting protein synthesis and metabolic needs in critically ill or postoperative settings.

GNH India supplies Kabiven Perifer as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and clinics worldwide through a regulated distribution network.

Manufacturer / TM Owner

Fresenius Kabi Ab

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Indications & Clinical Uses

Kabiven Perifer is employed in parenteral nutrition to meet protein and caloric requirements when oral or enteral intake is not possible.

  • Inability to receive enteral feeding: provides essential amino acids to sustain protein synthesis and metabolic balance.
  • Critical illness: supports caloric and nitrogen needs during intensive care or severe catabolism.
  • Post‑operative recovery: aids wound healing and muscle preservation when oral intake is delayed.

How It Works

  • Kabiven Perifer delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream. The amino acids serve as substrates for protein synthesis, replenish nitrogen stores, and support gluconeogenesis and other metabolic pathways. By bypassing the gastrointestinal tract, the solution ensures rapid availability of building blocks for tissue repair, immune function, and energy production, particularly in patients with compromised digestion or increased metabolic demand.

Side Effects

Kabiven Perifer may be associated with infusion‑related and systemic adverse reactions.

Common Side Effects

  • Infusion site erythema
  • Mild fever
  • Nausea
  • Electrolyte disturbances (e.g., mild hypernatremia)

Serious or Rare Side Effects

  • Anaphylactic reaction
  • Severe hyperglycemia
  • Catheter‑related bloodstream infection
  • Renal or hepatic dysfunction

Precautions & Warnings

When using Kabiven Perifer, clinicians should observe several safety precautions to minimize complications.

  • Assess renal and hepatic function before initiation: baseline labs guide dosing and monitoring.
  • Monitor blood glucose and electrolyte levels regularly: amino acid metabolism can affect glucose and sodium balance.
  • Adjust infusion rate based on patient tolerance: rapid administration may cause hypotension or discomfort.
  • Avoid mixing with incompatible solutions: incompatibility can cause precipitation or loss of efficacy.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Kabiven Perifer can interact with other medications or solutions administered intravenously.

Major Interactions (Avoid)

  • Concurrent high‑dose potassium solutions: may cause dangerous hyperkalemia.
  • Co‑administration with other amino‑acid formulations: risk of incompatibility and precipitation.
  • Use with nephrotoxic drugs: increased renal load may exacerbate kidney injury.

Moderate Interactions (Monitor Closely)

  • Concurrent insulin therapy: amino acids can raise blood glucose, requiring insulin dose adjustment.
  • Use with diuretics: monitor electrolytes closely for shifts in sodium and potassium.
  • Simultaneous administration of other parenteral nutrition components: watch osmolarity and fluid balance.

Frequently Asked Questions

Kabiven Perifer is an amino‑acid based parenteral nutrition solution used to provide essential proteins and calories to patients who cannot receive nutrition through the gastrointestinal tract. It is indicated for critically ill, postoperative or otherwise catabolic patients who require intravenous support to maintain nitrogen balance and promote tissue repair.

The mixture supplies a balanced profile of essential and non‑essential amino acids directly into the bloodstream. These amino acids act as building blocks for protein synthesis, replenish nitrogen stores, and support metabolic pathways such as gluconeogenesis. By delivering them intravenously, the formulation bypasses digestive absorption, ensuring rapid availability for cellular processes.

The dose of Kabiven Perifer is individualized. A prescribing clinician determines the volume and infusion rate based on the patient’s weight, metabolic needs, renal and hepatic function, and overall nutritional goals. No fixed regimen can be stated; dosing is adjusted according to laboratory monitoring and clinical response.

The pregnancy category for Kabiven Perifer is listed as unknown. Use during pregnancy or lactation should only occur when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Clinicians must evaluate each case carefully and consider alternative nutrition strategies when appropriate.

To order Kabiven Perifer, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details (including cold‑chain logistics if needed) and assists with import documentation.

Kabiven Perifer offers a comprehensive blend of ten amino acids that matches the profile of many standard commercial amino‑acid admixtures. Compared with some alternatives that contain additional non‑protein calories or different ratios, Kabiven Perifer focuses on essential amino acid provision, making it suitable for patients where precise protein dosing is required. Compatibility and stability are comparable when mixed according to manufacturer guidelines.

Kabiven Perifer must be stored refrigerated at 2‑8 °C. The container should be kept in its original packaging, protected from light, and must not be frozen or shaken. Prior to use, inspect the solution for particulates or discoloration and allow it to reach room temperature if required by the infusion protocol.

Kabiven Perifer is administered intravenously, typically via a peripheral or central venous catheter. The solution is infused over a period defined by the prescribing clinician, often 12‑24 hours, and may be diluted with compatible fluids according to the product label. Infusion pumps are recommended to control the rate and ensure patient safety.

The most serious risks include anaphylactic or severe hypersensitivity reactions, marked hyperglycemia, catheter‑related bloodstream infections, and significant renal or hepatic dysfunction. Prompt recognition of these events and immediate medical intervention are essential. Regular monitoring of vital signs, blood glucose, liver enzymes and renal function helps mitigate these risks.

Kabiven Perifer should be avoided in patients with known hypersensitivity to any of its amino‑acid components, in those with severe inborn errors of amino‑acid metabolism, and in individuals with uncontrolled hypernatremia or severe hepatic failure where amino‑acid load could worsen the condition. Clinicians must assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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