Product image of Kabiven Perifer (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Kabiven Perifer

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Kabiven Perifer (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serine, the active ingredients in Kabiven Perifer, is a amino acid solution presented as an intravenous solution for intravenous use. It provides essential amino acids for patients who require parenteral nutrition because they cannot receive enteral feeding.

GNH India supplies Kabiven Perifer as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide, with quality control, regulatory compliance and reliable cold‑chain logistics for this parenteral nutrition product.

Manufacturer / TM Owner

Fresenius Kabi Ab

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Indications & Clinical Uses

  • Kabiven Perifer is an amino acid solution used in parenteral nutrition to support protein synthesis and nitrogen balance.
  • Parenteral nutrition for patients unable to receive enteral feeding: supplies essential amino acids to maintain nitrogen balance and support metabolic needs.
  • Critical illness or postoperative state: provides substrates for protein synthesis and tissue repair during heightened catabolism.
  • Severe malnutrition: delivers a balanced amino acid profile to meet increased metabolic demands.

How It Works

  • Kabiven Perifer delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream. The amino acids serve as substrates for ribosomal protein synthesis, replenish intracellular pools, and help maintain nitrogen balance. By bypassing the gastrointestinal tract, the solution ensures rapid availability of building blocks for tissue repair, immune function and metabolic processes in patients receiving total parenteral nutrition.

Side Effects

Adverse reactions may occur with any intravenous amino acid preparation.

Common Side Effects

  • Infusion site erythema or pain
  • Mild hyperglycemia
  • Electrolyte disturbances (e.g., mild hyperkalemia or hypophosphatemia)
  • Nausea or vomiting

Serious or Rare Side Effects

  • Anaphylactic or severe hypersensitivity reactions
  • Severe hypernatremia or metabolic acidosis
  • Significant elevation of blood urea nitrogen indicating renal overload
  • Pulmonary edema from fluid overload

Precautions & Warnings

  • When using Kabiven Perifer, clinicians should observe the following precautions.
  • Assess renal function: adjust volume and monitor nitrogen load in patients with renal impairment.
  • Monitor electrolytes: regularly check serum potassium, phosphate and calcium levels.
  • Check for amino acid allergies: discontinue if hypersensitivity is observed.
  • Use aseptic technique: ensure sterility of the infusion set and solution.
  • Avoid mixing with incompatible solutions: do not combine with calcium‑containing or high‑pH fluids.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Kabiven Perifer may interact with other intravenous therapies.

Major Interactions (Avoid)

  • Concurrent high‑dose potassium solutions: risk of hyperkalemia.
  • Mixing with calcium‑containing solutions: precipitation may occur.
  • Co‑administration with other nitrogenous waste products (e.g., urea): can increase renal load.

Moderate Interactions (Monitor Closely)

  • Use with diuretics: may exacerbate electrolyte shifts.
  • Concurrent insulin therapy: monitor blood glucose closely.
  • Co‑infusion with parenteral lipid emulsions: observe triglyceride levels.

Frequently Asked Questions

Kabiven Perifer is an intravenous amino acid solution used as part of total parenteral nutrition. It supplies essential and non‑essential amino acids to patients who cannot receive enteral feeding, helping to maintain nitrogen balance, support protein synthesis, and meet metabolic needs during critical illness, surgery or severe malnutrition.

The formulation provides a balanced pool of amino acids that are directly available in the bloodstream. These amino acids act as substrates for ribosomal protein synthesis, replenish intracellular stores, and support metabolic pathways that require nitrogen. By delivering them intravenously, the solution bypasses the gastrointestinal tract, ensuring rapid and reliable availability for tissue repair and immune function.

The prescribed dose of Kabiven Perifer is individualized by the treating clinician. Factors such as the patient’s weight, age, renal and hepatic function, overall nitrogen balance, and the total caloric goals of the parenteral regimen are considered. The prescriber calculates the appropriate volume and rate to meet the specific nutritional requirements of each patient.

Safety data for Kabiven Perifer in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Clinicians must evaluate the clinical situation carefully and follow local regulatory guidance before prescribing this product to pregnant or nursing patients.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Kabiven Perifer. GNH India works with hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details (including cold‑chain handling if needed) and any required import documentation.

Kabiven Perifer offers a comprehensive blend of ten essential and non‑essential amino acids in a single sterile IV bag, matching the amino acid profile recommended for adult total parenteral nutrition. Compared with some older formulations that contain fewer amino acids or require multiple bags, Kabiven Perifer simplifies preparation, reduces the risk of incompatibility, and provides a balanced nitrogen source for a broad range of clinical scenarios.

Kabiven Perifer must be stored refrigerated at 2 °C to 8 °C. The solution should be kept in its original container, protected from light, and must not be frozen or shaken. Maintaining the cold chain preserves the stability of the amino acids and prevents microbial growth.

Kabiven Perifer is administered intravenously as part of a total parenteral nutrition regimen. The sterile solution is infused through a dedicated IV line using an infusion pump or gravity set, following aseptic technique. The rate and total volume are determined by the prescribing clinician based on the patient’s nutritional goals and fluid balance.

Serious risks include severe hypersensitivity reactions such as anaphylaxis, marked electrolyte disturbances (e.g., hypernatremia, severe hyperkalemia), significant elevation of blood urea nitrogen indicating renal overload, and fluid overload leading to pulmonary edema. Prompt recognition and management of these events are essential, and patients should be monitored closely during infusion.

Kabiven Perifer should be avoided in patients with known hypersensitivity to any of its amino acid components, those with uncontrolled severe electrolyte imbalances, or individuals with acute renal failure where additional nitrogen load could worsen renal function. It is also contraindicated when compatible infusion solutions cannot be ensured, as precipitation may occur.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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