Kabiven Peripher (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Kabiven Peripher, an amino acid solution for parenteral nutrition, addresses protein and energy deficits in patients with increased metabolic demand.

• Parenteral nutrition: Provides essential amino acids for patients unable to meet nutritional needs orally or enterally.
• Peri‑operative support: Supplements essential amino acids in surgical patients to promote wound healing and recovery.
• Critical illness: Supports protein synthesis in critically ill patients with high catabolic rates.

• Kabiven Peripher delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream. The amino acids serve as substrates for ribosomal protein synthesis, replenish nitrogen pools, and support the synthesis of acute‑phase proteins and enzymes. By correcting amino acid deficiencies, the solution helps maintain plasma oncotic pressure, supports immune function, and facilitates tissue repair during periods of catabolism.

Intravenous administration of Kabiven Peripher may be associated with the following adverse reactions.

Common Side Effects

• Infusion site erythema: Redness or mild irritation at the catheter insertion site.
• Phlebitis: Inflammation of the vein used for infusion.
• Nausea: Transient feeling of queasiness during or after infusion.
• Elevated blood urea nitrogen: Mild increase reflecting nitrogen load.

Serious or Rare Side Effects

• Anaphylactic reaction: Severe allergic response requiring immediate medical intervention.
• Metabolic acidosis: Significant acid‑base disturbance due to amino acid metabolism.
• Renal failure: Acute deterioration of kidney function in susceptible patients.
• Sepsis: Infection related to catheter use or contaminated solution.

When using Kabiven Peripher, clinicians should observe the following precautions to ensure patient safety.

• Renal impairment: Monitor nitrogen balance and adjust infusion rate.
• Hepatic dysfunction: Evaluate liver function tests and consider amino acid composition.
• Electrolyte disorders: Check serum electrolytes regularly during therapy.
• Hyperglycemia risk: Observe blood glucose levels, especially in diabetic patients.
• Compatibility: Do not mix with calcium‑containing solutions to avoid precipitation.
• Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Kabiven Peripher can interact with other intravenously administered agents; awareness of these interactions helps prevent complications.

Major Interactions (Avoid)

• Concurrent high‑dose potassium solutions: May cause hyperkalemia.
• Calcium‑containing infusions: Risk of precipitation with amino acids.
• Nephrotoxic drugs: Increased renal load and potential toxicity.

Moderate Interactions (Monitor Closely)

• Insulin therapy: May require adjustment of glucose monitoring.
• Other parenteral nutrition components: Total nitrogen and caloric intake should be balanced.
• Diuretics: Monitor electrolyte shifts and volume status.