Product image of Kabiven Peripheral (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Kabiven Peripheral

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Kabiven Peripheral (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Valine, the active ingredient in Kabiven Peripheral, is an amino acid solution presented as a solution for injection for intravenous use. It provides essential and non‑essential amino acids to patients who cannot receive enteral feeding, supporting protein synthesis, nitrogen balance, and metabolic stability in surgical, critically ill, or nutritionally compromised individuals. It also helps maintain acid‑base equilibrium during intensive care.

GNH India supplies Kabiven Peripheral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, and oncology clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Ab

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Indications & Clinical Uses

Kabiven Peripheral is used in parenteral nutrition to provide amino acids for patients unable to receive enteral feeding.

  • Enteral feeding intolerance: supplies essential amino acids to maintain protein synthesis when oral or tube feeding is not possible.
  • Surgical patients: supports nitrogen balance and wound healing during the peri‑operative period.
  • Critically ill patients: helps preserve lean body mass and metabolic stability in intensive care settings.

How It Works

  • When administered intravenously, Kabiven Peripheral delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream. These amino acids serve as substrates for protein synthesis, replenish nitrogen stores, and act as precursors for neurotransmitters, hormones, and metabolic intermediates, thereby supporting cellular function and metabolic homeostasis without requiring gastrointestinal absorption. The formulation is isotonic and compatible with standard infusion sets, allowing seamless integration into total parenteral nutrition regimens.

Side Effects

Kabiven Peripheral may be associated with infusion‑related and metabolic adverse reactions.

Common Side Effects

  • Hyperglycemia: elevated blood glucose levels, especially in diabetic patients.
  • Electrolyte imbalance: changes in serum potassium, sodium, or calcium.
  • Phlebitis: irritation or inflammation at the IV site.
  • Fluid overload: excess volume leading to edema or pulmonary congestion.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe hypersensitivity requiring immediate medical intervention.
  • Metabolic acidosis: significant drop in blood pH due to amino acid metabolism.
  • Renal dysfunction: impaired kidney function from nitrogen load.
  • Thrombosis: formation of blood clots at the catheter site.

Precautions & Warnings

Prior to initiating Kabiven Peripheral, clinicians should consider the following precautions.

  • Renal impairment: monitor serum creatinine and adjust infusion rate.
  • Electrolyte disturbances: check serum electrolytes regularly and correct abnormalities.
  • Hyperglycemia: monitor blood glucose in patients with diabetes or stress hyperglycemia.
  • Fluid balance: assess volume status to avoid overload, especially in heart failure.
  • Compatibility: use only compatible IV solutions as recommended by the manufacturer.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Kabiven Peripheral can interact with certain medications and solutions; awareness of these interactions helps ensure safe use.

Major Interactions (Avoid)

  • Concurrent high‑dose amino acid solutions: risk of nitrogen overload and metabolic imbalance.
  • Incompatible IV admixtures containing calcium or phosphate: may cause precipitation and catheter blockage.

Moderate Interactions (Monitor Closely)

  • Insulin therapy: amino acid infusion can raise blood glucose, requiring insulin dose adjustment.
  • Diuretics: may exacerbate electrolyte shifts; monitor serum levels closely.
  • Renal replacement therapy: may remove amino acids, necessitating dosage reassessment.

Frequently Asked Questions

Kabiven Peripheral is an intravenous amino acid solution used as part of total parenteral nutrition. It provides essential and non‑essential amino acids to patients who cannot receive enteral feeding, helping maintain protein synthesis, nitrogen balance, and overall metabolic stability during surgery, critical illness, or other conditions that limit oral intake.

The mixture delivers a balanced profile of essential and non‑essential amino acids directly into the bloodstream. These amino acids act as building blocks for protein synthesis, replenish nitrogen stores, and serve as precursors for hormones, neurotransmitters, and metabolic intermediates, thereby supporting cellular function and metabolic homeostasis without relying on gastrointestinal absorption.

The dosage of Kabiven Peripheral is individualized and set by the prescribing clinician based on the patient’s weight, clinical condition, nitrogen needs, renal function, and overall nutritional goals. Healthcare professionals calculate the appropriate infusion rate and volume to meet the specific protein and caloric requirements of each patient.

Safety data for Kabiven Peripheral in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Clinicians must evaluate each case carefully and follow local regulatory guidance.

To order Kabiven Peripheral, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required), and necessary import documentation.

Kabiven Peripheral offers a comprehensive blend of essential and non‑essential amino acids formulated for peripheral administration, which may provide better tolerability in peripheral veins compared with some high‑concentration central‑line products. Its EU‑origin manufacturing ensures compliance with stringent quality standards, while the amino acid profile is designed to meet typical adult nutritional requirements.

Kabiven Peripheral must be stored at 2‑8 °C in a refrigerator. Keep the container in its original packaging, protect it from light, and avoid freezing or shaking the solution. Do not use the product if it has been exposed to temperatures outside this range or shows signs of precipitation.

Kabiven Peripheral is administered intravenously as a sterile solution for injection. It is typically infused through a peripheral vein using an infusion pump or gravity set, following the rate and volume prescribed by the clinician. The solution can be combined with other components of total parenteral nutrition as directed.

Serious risks include anaphylactic reactions, metabolic acidosis, renal dysfunction from excessive nitrogen load, and thrombosis at the catheter site. Prompt recognition of these events and immediate medical intervention are essential. Monitoring of vital signs, laboratory parameters, and infusion site is recommended throughout therapy.

Kabiven Peripheral should be avoided in patients with known hypersensitivity to any of its amino acid components, severe renal impairment where nitrogen excretion is compromised, uncontrolled hyperglycemia, or in those receiving incompatible intravenous solutions that may precipitate. Clinicians must assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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